The telosome/shelterin complex and its functions (2008)
Xin, Huawei, Liu, Dan, Songyang, Zhou
Abstract The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of...
A Proteomic Approach to Identify Phosphorylation-Dependent Targets of BRCT Domains (2007)
BRCA1 C-terminal (BRCT) domains are novel phosphopeptide binding modules. Cancer-associated missense and deletion mutations have been found in the BRCT repeat regions of BRCA1, suggesting an...
Domain-dependent Function of the rasGAP-binding Protein p62Dok in Cell Signaling (2001)
Songyang, Zhou, Yamanashi, Yuji, Liu, Dan, Baltimore, David
p62Dok, the rasGAP-binding protein, is a common target of protein-tyrosine kinases. It is one of the major tyrosine-phosphorylated molecules in v-Src-transformed cells. Dok consists of an...
Genetic and Functional Studies of Genes that Regulate DNA-Damage-Induced Cell Death (1998)
Studies have shown that apoptosis and survival pathways in response to DNA damage play a critical role in breast cancer development and progression. 90% of breast cancer cases are sporadic where...
Identification of Signaling Proteins that Modulate Androgen Receptor Activity (1998)
Androgens and the androgen receptor (AR) play a critical role in the development and progression of prostate cancers. The majority of prostate cancers initially respond to endocrine treatment...
Identification of Signaling Proteins That Modulate Androgen Receptor Activity (1998)
Androgens and the androgen receptor (AR) play a critical role in the development and progression of prostate cancers. The majority of prostate cancers initially respond to endocrine treatment...
Genetic and Functional Studies of Genes That Regulate DNA-Damage-Induced Cell Death (1998)
Studies have shown that apoptosis and survival pathways in response to DNA damage play a critical role in breast cancer development and progression. 90% of breast cancer cases are sporadic where...
Identification of Signaling Proteins the Modulate Androgen Receptor Activity (1998)
Androgens and the androgen receptor (AR) play a critical role in the development and progression of prostate cancers. The majority of prostate cancers initially respond to endocrine treatment...
Genetic and Functional Studies of Genes that Regulate DNA-Damage-Induced Cell Death (1998)
Studies have shown that apoptosis and survival pathways in response to DNA damage play a critical role in breast cancer development and progression. 90% of breast cancer cases are sporadic where...
Genetic and Functional Studies of Genes That Regulate DNA-Damage-Induced Cell Death (1998)
Studies have shown that apoptosis and survival pathways in response to DNA damage play a critical role in breast cancer development and progression. 90% of breast cancer cases are sporadic where...
Interleukin 3-dependent survival by the Akt protein kinase (1997)
Songyang, Zhou, Baltimore, David, Cantley, Lewis C., Kaplan, David R., Franke, Thomas F.
Interleukin 3 (IL-3)-dependent survival of hematopoietic cells is known to rely on the activity of multiple signaling pathways, including a pathway leading to activation of phosphoinositide 3-kinase...
Interleukin 3-dependent survival by the Akt protein kinase
Songyang, Zhou, Baltimore, David, Cantley, Lewis C., Kaplan, David R., Franke, Thomas F.
Interleukin 3 (IL-3)-dependent survival of hematopoietic cells is known to rely on the activity of multiple signaling pathways, including a pathway leading to activation of phosphoinositide 3-kinase...
Li, Shun-Cheng, Songyang, Zhou, Vincent, Sébastien J. F., Zwahlen, Catherine, Wiley, Sandra, Cantley, Lewis, ...
The phosphotyrosine-binding (PTB) domain is a recently identified protein module that has been characterized as binding to phosphopeptides containing an NPXpY motif (X = any amino acid). We describe...
Endosomal localization and function of sorting nexin 1
Zhong, Qi, Lazar, Cheri S., Tronchère, Hélène, Sato, Trey, Meerloo, Timo, Yeo, Michele, ...
There are 17 human members of the sorting nexin (SNX) family of proteins that contain Phox (PX) domains. Yeast orthologs function in vesicular trafficking and mammalian proteins have been implicated...
A Wnt- and β-catenin-dependent pathway for mammalian cardiac myogenesis
Nakamura, Teruya, Sano, Motoaki, Songyang, Zhou, Schneider, Michael D.
Acquisition of a cardiac fate by embryonic mesodermal cells is a fundamental step in heart formation. Heart development in frogs and avians requires positive signals from adjacent endoderm, including...
Luo, Hao, Chan, Doug W., Yang, Tao, Rodriguez, Maria, Chen, Benjamin Ping-Chi, Leng, Mei, ...
DNA single-strand break repair (SSBR) is important for maintaining genome stability and homeostasis. The current SSBR model derived from an in vitro-reconstituted reaction suggests that the SSBR...
Interleukin 3-dependent survival by the Akt protein kinase
Songyang, Zhou, Baltimore, David, Cantley, Lewis C., Kaplan, David R., Franke, Thomas F.
Interleukin 3 (IL-3)-dependent survival of hematopoietic cells is known to rely on the activity of multiple signaling pathways, including a pathway leading to activation of phosphoinositide 3-kinase...
Li, Shun-Cheng, Songyang, Zhou, Vincent, Sébastien J. F., Zwahlen, Catherine, Wiley, Sandra, Cantley, Lewis, ...
The phosphotyrosine-binding (PTB) domain is a recently identified protein module that has been characterized as binding to phosphopeptides containing an NPXpY motif (X = any amino acid). We describe...
Endosomal localization and function of sorting nexin 1
Zhong, Qi, Lazar, Cheri S., Tronchère, Hélène, Sato, Trey, Meerloo, Timo, Yeo, Michele, ...
There are 17 human members of the sorting nexin (SNX) family of proteins that contain Phox (PX) domains. Yeast orthologs function in vesicular trafficking and mammalian proteins have been implicated...
A Wnt- and β-catenin-dependent pathway for mammalian cardiac myogenesis
Nakamura, Teruya, Sano, Motoaki, Songyang, Zhou, Schneider, Michael D.
Acquisition of a cardiac fate by embryonic mesodermal cells is a fundamental step in heart formation. Heart development in frogs and avians requires positive signals from adjacent endoderm, including...
Luo, Hao, Chan, Doug W., Yang, Tao, Rodriguez, Maria, Chen, Benjamin Ping-Chi, Leng, Mei, ...
DNA single-strand break repair (SSBR) is important for maintaining genome stability and homeostasis. The current SSBR model derived from an in vitro-reconstituted reaction suggests that the SSBR...
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
O'Connor, Matthew S., Safari, Amin, Xin, Huawei, Liu, Dan, Songyang, Zhou
Mammalian telomeric proteins function through dynamic interactions with each other and telomere DNA. We previously reported the formation of a high-molecular-mass telomeric complex (the mammalian...
A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners
Ding, Zhiyong, Liang, Jiyong, Lu, Yiling, Yu, Qinghua, Songyang, Zhou, Lin, Shiaw-Yih, ...
We developed a retrovirus-based protein-fragment complementation assay (RePCA) screen to identify protein–protein interactions in mammalian cells. In RePCA, bait protein is fused to one fragment of...
Telomere Maintenance through Spatial Control of Telomeric Proteins▿
Chen, Liuh-Yow, Liu, Dan, Songyang, Zhou
The six human telomeric proteins TRF1, TRF2, RAP1, TIN2, POT1, and TPP1 can form a complex called the telosome/shelterin, which is required for telomere protection and length control. TPP1 has been...
Bullock, Alex N., Rodriguez, Maria C., Debreczeni, Judit É., Songyang, Zhou, Knapp, Stefan
Tyrosine kinase signaling is tightly controlled by negative feedback inhibitors including suppressors of cytokine signaling (SOCS). SOCS assemble as SH2 domain substrate recognition modules in...
Wang, Huan-You, Lin, Wen, Dyck, Jacqueline A., Yeakley, Joanne M., Songyang, Zhou, Cantley, Lewis C., ...
Abstract. Reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian cells. Two kinases, SR protein-specific kinase (SRPK1) and Clk/Sty, have been shown to phosphorylate the...
Xu, Jun, Liu, Dan, Gill, Gordon, Songyang, Zhou
PKB/Akt and serum and glucocorticoid–regulated kinase (SGK) family kinases are important downstream targets of phosphatidylinositol 3 (PI-3) kinase and have been shown to mediate a variety of...
The telosome/shelterin complex and its functions
Xin, Huawei, Liu, Dan, Songyang, Zhou
The telosome/shelterin protein complex bound to telomeres is essential for maintenance of telomere structure and telomere signaling functions.