Zhanyun Tang

APC2 Cullin Protein and APC11 RING Protein Comprise the Minimal Ubiquitin Ligase Module of the Anaphase-promoting Complex

Tang, Zhanyun, Li, Bing, Bharadwaj, Rajnish, Zhu, Haizhen, Özkan, Engin, Hakala, Kevin, ...

In mitosis, the anaphase-promoting complex (APC) regulates the onset of sister-chromatid separation and exit from mitosis by mediating the ubiquitination and degradation of the securin protein and...

Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila

Araki, Marito, Wharton, Robin P., Tang, Zhanyun, Yu, Hongtao, Asano, Maki

The initiation of DNA synthesis is thought to occur at sites bound by a heteromeric origin recognition complex (ORC). Previously, we have shown that in Drosophila, the level of the large subunit,...

Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis

Tang, Zhanyun, Sun, Yuxiao, Harley, Sara E., Zou, Hui, Yu, Hongtao

Sister chromatids in mammalian cells remain attached mostly at their centromeres at metaphase because of the loss of cohesion along chromosome arms in prophase. Here, we report that Bub1 retains...

HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule

Liu, Baoying, Hong, Sohee, Tang, Zhanyun, Yu, Hongtao, Giam, Chou-Zen

Expression of the human T lymphotropic virus type I (HTLV-I) transactivator/oncoprotein, Tax, leads to faulty mitosis as reflected by chromosome aneuploidy, cytokinesis failure, and formation of...

Phosphorylation- and Polo-Box–dependent Binding of Plk1 to Bub1 Is Required for the Kinetochore Localization of Plk1

Qi, Wei, Tang, Zhanyun, Yu, Hongtao

Polo-like kinase 1 (Plk1) is required for the generation of the tension-sensing 3F3/2 kinetochore epitope and facilitates kinetochore localization of Mad2 and other spindle checkpoint proteins. Here,...

APC2 Cullin Protein and APC11 RING Protein Comprise the Minimal Ubiquitin Ligase Module of the Anaphase-promoting Complex

Tang, Zhanyun, Li, Bing, Bharadwaj, Rajnish, Zhu, Haizhen, Özkan, Engin, Hakala, Kevin, ...

In mitosis, the anaphase-promoting complex (APC) regulates the onset of sister-chromatid separation and exit from mitosis by mediating the ubiquitination and degradation of the securin protein and...

Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila

Araki, Marito, Wharton, Robin P., Tang, Zhanyun, Yu, Hongtao, Asano, Maki

The initiation of DNA synthesis is thought to occur at sites bound by a heteromeric origin recognition complex (ORC). Previously, we have shown that in Drosophila, the level of the large subunit,...

Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis

Tang, Zhanyun, Sun, Yuxiao, Harley, Sara E., Zou, Hui, Yu, Hongtao

Sister chromatids in mammalian cells remain attached mostly at their centromeres at metaphase because of the loss of cohesion along chromosome arms in prophase. Here, we report that Bub1 retains...

HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule

Liu, Baoying, Hong, Sohee, Tang, Zhanyun, Yu, Hongtao, Giam, Chou-Zen

Expression of the human T lymphotropic virus type I (HTLV-I) transactivator/oncoprotein, Tax, leads to faulty mitosis as reflected by chromosome aneuploidy, cytokinesis failure, and formation of...

Phosphorylation- and Polo-Box–dependent Binding of Plk1 to Bub1 Is Required for the Kinetochore Localization of Plk1

Qi, Wei, Tang, Zhanyun, Yu, Hongtao

Polo-like kinase 1 (Plk1) is required for the generation of the tension-sensing 3F3/2 kinetochore epitope and facilitates kinetochore localization of Mad2 and other spindle checkpoint proteins. Here,...