Zhanguo Gao

COACTIVATORS AND COREPRESSORS OF NF-KB IN IkB ALPHA GENE PROMOTER

Gao, Zhanguo, Chiao, Paul, Zhang, Xia, Zhang, Xiaohong, Lazar, Mitchell, Seto, Edward, ...

In this study, we investigated recruitment of coactivators (SRC-1, SRC-2 and SRC-3) and corepressors (HDAC1, HDAC2, HDAC3, SMRT and NCoR) to the IkBα gene promoter after NF-kB activation by TNF-α....

REGULATION OF NUCLEAR TRANSLOCATION OF HDAC3 BY IKBα IS REQUIRED FOR TNF-INHIBITION OF PPARγ FUNCTION

Gao, Zhanguo, He, Qing, Peng, Bailu, Chiao, Paul, Ye, Jianping

Inhibition of PPARγ function by TNF-α contributes to metabolic disorder in glucose and fatty acids under inflammation and cancer, but the molecular mechanism remains to be fully understood. In this...