Domain-dependent Function of the rasGAP-binding Protein p62Dok in Cell Signaling (2001)
Songyang, Zhou, Yamanashi, Yuji, Liu, Dan, Baltimore, David
p62Dok, the rasGAP-binding protein, is a common target of protein-tyrosine kinases. It is one of the major tyrosine-phosphorylated molecules in v-Src-transformed cells. Dok consists of an...
Tanaka, Michiko, Yokoyama, Akihiko, Igarashi, Mie, Matsuda, Go, Kato, Kentaro, Kanamori, Mikiko, ...
Self-association of viral proteins is important for many of their functions, including enzymatic, transcriptional, and transformational activities. Epstein-Barr virus (EBV) nuclear antigen leader...
Shirakata, Masaki, Terauchi, Masakazu, Ablikim, Melike, Imadome, Ken-Ichi, Hirai, Kanji, Aso, Takeshi, ...
The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) expresses IE86, IE72, IE55, and IE18 mRNA by differential splicing. Reverse transcription-PCR with IE72-specific primers generated...
Tanaka, Michiko, Kagawa, Hiroyuki, Yamanashi, Yuji, Sata, Tetsutaro, Kawaguchi, Yasushi
In recent years, several laboratories have reported on the cloning of herpes simplex virus type 1 (HSV-1) genomes as bacterial artificial chromosomes (BACs) in Escherichia coli and on procedures to...
Kawaguchi, Yasushi, Kato, Kentaro, Tanaka, Michiko, Kanamori, Mikiko, Nishiyama, Yukihiro, Yamanashi, Yuji
Earlier studies have shown that translation elongation factor 1δ (EF-1δ) is hyperphosphorylated in various mammalian cells infected with representative alpha-, beta-, and gammaherpesviruses and...
CD40 ligand is a critical effector of Epstein–Barr virus in host cell survival and transformation
Imadome, Ken-Ichi, Shirakata, Masaki, Shimizu, Norio, Nonoyama, Shigeaki, Yamanashi, Yuji
Epstein–Barr virus (EBV), implicated in numerous human diseases, including lymphoid malignancies, persistently infects peripheral B cells and transforms them into lymphoblastoid cell lines. Here we...
Terauchi, Masakazu, Koi, Hideki, Hayano, Chikako, Toyama-Sorimachi, Noriko, Karasuyama, Hajime, Yamanashi, Yuji, ...
Human cytomegalovirus (HCMV) downregulates the class I major histocompatibility complexes (MHCs), HLA-A and -B, in infected fibroblasts to escape from antigen-specific cytotoxic T lymphocytes. The...
Yamanashi, Yuji, Tamura, Toshiki, Kanamori, Toshihide, Yamane, Hidehiro, Nariuchi, Hideo, Yamamoto, Tadashi, ...
Antigenic stimulation of the B-cell receptor (BCR) is a central event in the immune response. In contrast, antigen bound to IgG negatively regulates signals from the BCR by cross-linking it to the...
Tanaka, Michiko, Yokoyama, Akihiko, Igarashi, Mie, Matsuda, Go, Kato, Kentaro, Kanamori, Mikiko, ...
Self-association of viral proteins is important for many of their functions, including enzymatic, transcriptional, and transformational activities. Epstein-Barr virus (EBV) nuclear antigen leader...
Shirakata, Masaki, Terauchi, Masakazu, Ablikim, Melike, Imadome, Ken-Ichi, Hirai, Kanji, Aso, Takeshi, ...
The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) expresses IE86, IE72, IE55, and IE18 mRNA by differential splicing. Reverse transcription-PCR with IE72-specific primers generated...
Tanaka, Michiko, Kagawa, Hiroyuki, Yamanashi, Yuji, Sata, Tetsutaro, Kawaguchi, Yasushi
In recent years, several laboratories have reported on the cloning of herpes simplex virus type 1 (HSV-1) genomes as bacterial artificial chromosomes (BACs) in Escherichia coli and on procedures to...
Kawaguchi, Yasushi, Kato, Kentaro, Tanaka, Michiko, Kanamori, Mikiko, Nishiyama, Yukihiro, Yamanashi, Yuji
Earlier studies have shown that translation elongation factor 1δ (EF-1δ) is hyperphosphorylated in various mammalian cells infected with representative alpha-, beta-, and gammaherpesviruses and...
CD40 ligand is a critical effector of Epstein–Barr virus in host cell survival and transformation
Imadome, Ken-Ichi, Shirakata, Masaki, Shimizu, Norio, Nonoyama, Shigeaki, Yamanashi, Yuji
Epstein–Barr virus (EBV), implicated in numerous human diseases, including lymphoid malignancies, persistently infects peripheral B cells and transforms them into lymphoblastoid cell lines. Here we...
Terauchi, Masakazu, Koi, Hideki, Hayano, Chikako, Toyama-Sorimachi, Noriko, Karasuyama, Hajime, Yamanashi, Yuji, ...
Human cytomegalovirus (HCMV) downregulates the class I major histocompatibility complexes (MHCs), HLA-A and -B, in infected fibroblasts to escape from antigen-specific cytotoxic T lymphocytes. The...
Yamanashi, Yuji, Tamura, Toshiki, Kanamori, Toshihide, Yamane, Hidehiro, Nariuchi, Hideo, Yamamoto, Tadashi, ...
Antigenic stimulation of the B-cell receptor (BCR) is a central event in the immune response. In contrast, antigen bound to IgG negatively regulates signals from the BCR by cross-linking it to the...
Role of Dok-1 and Dok-2 in Myeloid Homeostasis and Suppression of Leukemia
Yasuda, Tomoharu, Shirakata, Masaki, Iwama, Atsushi, Ishii, Asuka, Ebihara, Yasuhiro, Osawa, Mitsujiro, ...
Dok-1 and Dok-2 are closely related rasGAP-associated docking proteins expressed preferentially in hematopoietic cells. Although they are phosphorylated upon activation of many protein tyrosine...
Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling
Shinohara, Hisaaki, Inoue, Akane, Toyama-Sorimachi, Noriko, Nagai, Yoshinori, Yasuda, Tomoharu, Suzuki, Hiromi, ...
Endotoxin, a bacterial lipopolysaccharide (LPS), causes fatal septic shock via Toll-like receptor (TLR)4 on effector cells of innate immunity like macrophages, where it activates nuclear factor κB...
Cbl-b Positively Regulates Btk-mediated Activation of Phospholipase C-γ2 in B Cells
Yasuda, Tomoharu, Tezuka, Tohru, Maeda, Akito, Inazu, Tetsuya, Yamanashi, Yuji, Gu, Hua, ...
Genetic studies have revealed that Cbl-b plays a negative role in the antigen receptor–mediated proliferation of lymphocytes. However, we show that Cbl-b–deficient DT40 B cells display reduced...
Role of Tyrosine Phosphorylation of HS1 in B Cell Antigen Receptor-mediated Apoptosis
Yamanashi, Yuji, Fukuda, Takahiro, Nishizumi, Hirofumi, Inazu, Tetsuya, Higashi, Ken-ichi, Kitamura, Daisuke, ...
The 75-kD HS1 protein is highly tyrosine-phosphorylated during B cell antigen receptor (BCR)-mediated signaling. Owing to low expression of HS1, WEHI-231-derived M1 cells, unlike the parental cells,...