Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality
Hesse, Michael, Franz, Thomas, Tamai, Yoshitaka, Taketo, Makoto M., Magin, Thomas M.
It has been reported previously that keratin 8 (K8)-deficient mice of one strain die from a liver defect at around E12.5, while those of another strain suffer from colorectal hyperplasia. These...
Kelly, Vincent P., Suzuki, Takafumi, Nakajima, Osamu, Arai, Tsuyoshi, Tamai, Yoshitaka, Takahashi, Satoru, ...
Appropriate expression of the selenocysteine tRNA (tRNASec) gene is necessary for the production of an entire family of selenoprotein enzymes. This study investigates the consequence of disrupting an...
Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality
Hesse, Michael, Franz, Thomas, Tamai, Yoshitaka, Taketo, Makoto M., Magin, Thomas M.
It has been reported previously that keratin 8 (K8)-deficient mice of one strain die from a liver defect at around E12.5, while those of another strain suffer from colorectal hyperplasia. These...
Kelly, Vincent P., Suzuki, Takafumi, Nakajima, Osamu, Arai, Tsuyoshi, Tamai, Yoshitaka, Takahashi, Satoru, ...
Appropriate expression of the selenocysteine tRNA (tRNASec) gene is necessary for the production of an entire family of selenoprotein enzymes. This study investigates the consequence of disrupting an...
Hepatic De Novo Lipogenesis Is Present in Liver-Specific ACC1-Deficient Mice▿ †
Harada, Naomoto, Oda, Zenjun, Hara, Yoshikazu, Fujinami, Koji, Okawa, Mayumi, Ohbuchi, Katsuya, ...
Acetyl coenzyme A (acetyl-CoA) carboxylase (ACC) catalyzes carboxylation of acetyl-CoA to form malonyl-CoA. In mammals, two isozymes exist with distinct physiological roles: cytosolic ACC1...
Hepatic De Novo Lipogenesis Is Present in Liver-Specific ACC1-Deficient Mice
Harada, Naomoto, Oda, Zenjun, Hara, Yoshikazu, Fujinami, Koji, Okawa, Mayumi, Ohbuchi, Katsuya, ...
Cytokeratins 8 and 19 in the Mouse Placental Development
Tamai, Yoshitaka, Ishikawa, Tomo-o, Bösl, Michael R., Mori, Masahiko, Nozaki, Masami, Baribault, Heléne, ...
To investigate the expression and biological roles of cytokeratin 19 (K19) in development and in adult tissues, we inactivated the mouse K19 gene (Krt1-19) by inserting a bacterial β-galactosidase...
Establishment of Rat Embryonic Stem Cells and Making of Chimera Rats
Ueda, Shinobu, Kawamata, Masaki, Teratani, Takumi, Shimizu, Taku, Tamai, Yoshitaka, Ogawa, Hiromasa, ...
The rat is a reference animal model for physiological studies and for the analysis of multigenic human diseases such as hypertension, diabetes, neurological disorders, and cancer. The rats have long...