Generation of medaka gene knockout models by target-selected mutagenesis (2006)
Taniguchi, Yoshihito, Takeda, Shunichi, Furutani-Seiki, Makoto, Kamei, Yasuhiro, Todo, Takeshi, Sasado, Takao, ...
Abstract We have established a reverse genetics approach for the routine generation of medaka ( Oryzias latipes ) gene knockouts. A cryopreserved library of N -ethyl- N -nitrosourea (ENU) mutagenized...
Mizutani, Tomohiko, Taniguchi, Yoshihito, Aoki, Tomokazu, Hashimoto, Nobuo, Honjo, Tasuku
Mouse Notch1, which plays an important role in cell fate determination in development, is proteolytically processed within its transmembrane domain by unidentified γ-secretase-like activity that...
Sakai, Takashi, Taniguchi, Yoshihito, Tamura, Kumiko, Minoguchi, Shigeru, Fukuhara, Takataro, Strobl, Lothar J., ...
The intracellular region (RAMIC) of the mouse Notch1 receptor interacts with RBP-J/CBF-1, which binds to the DNA sequence CGTGGGAA and suppresses differentiation by transcriptional activation of...
Taniguchi, Yoshihito, Furukawa, Takahisa, Tun, Tin, Han, Hua, Honjo, Tasuku
The RBP-J/Su(H) DNA-binding protein plays a key role in transcriptional regulation by targeting Epstein-Barr virus nuclear antigen 2 (EBNA2) and the intracellular portions of Notch receptors to...
Notch receptor cleavage depends on but is not directly executed by presenilins
Taniguchi, Yoshihito, Karlström, Helena, Lundkvist, Johan, Mizutani, Tomohiko, Otaka, Akira, Vestling, Monica, ...
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the...
RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2
Qin, Hongyan, Wang, Jishu, Liang, Yingmin, Taniguchi, Yoshihito, Tanigaki, Kenji, Han, Hua
The DNA-binding protein recombination signal binding protein-Jκ (RBP-J) mediates transcriptional activation of the Notch intracellular domain (NIC). In the absence of transcriptional activators,...
Fen-1 Facilitates Homologous Recombination by Removing Divergent Sequences at DNA Break Ends†
Kikuchi, Koji, Taniguchi, Yoshihito, Hatanaka, Atsushi, Sonoda, Eiichiro, Hochegger, Helfrid, Adachi, Noritaka, ...
Homologous recombination (HR) requires nuclease activities at multiple steps, but the contribution of individual nucleases to the processing of double-strand DNA ends at different stages of HR has...
Mizutani, Tomohiko, Taniguchi, Yoshihito, Aoki, Tomokazu, Hashimoto, Nobuo, Honjo, Tasuku
Mouse Notch1, which plays an important role in cell fate determination in development, is proteolytically processed within its transmembrane domain by unidentified γ-secretase-like activity that...
Sakai, Takashi, Taniguchi, Yoshihito, Tamura, Kumiko, Minoguchi, Shigeru, Fukuhara, Takataro, Strobl, Lothar J., ...
The intracellular region (RAMIC) of the mouse Notch1 receptor interacts with RBP-J/CBF-1, which binds to the DNA sequence CGTGGGAA and suppresses differentiation by transcriptional activation of...
Taniguchi, Yoshihito, Furukawa, Takahisa, Tun, Tin, Han, Hua, Honjo, Tasuku
The RBP-J/Su(H) DNA-binding protein plays a key role in transcriptional regulation by targeting Epstein-Barr virus nuclear antigen 2 (EBNA2) and the intracellular portions of Notch receptors to...
Notch receptor cleavage depends on but is not directly executed by presenilins
Taniguchi, Yoshihito, Karlström, Helena, Lundkvist, Johan, Mizutani, Tomohiko, Otaka, Akira, Vestling, Monica, ...
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the...
RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2
Qin, Hongyan, Wang, Jishu, Liang, Yingmin, Taniguchi, Yoshihito, Tanigaki, Kenji, Han, Hua
The DNA-binding protein recombination signal binding protein-Jκ (RBP-J) mediates transcriptional activation of the Notch intracellular domain (NIC). In the absence of transcriptional activators,...
Fen-1 Facilitates Homologous Recombination by Removing Divergent Sequences at DNA Break Ends†
Kikuchi, Koji, Taniguchi, Yoshihito, Hatanaka, Atsushi, Sonoda, Eiichiro, Hochegger, Helfrid, Adachi, Noritaka, ...
Homologous recombination (HR) requires nuclease activities at multiple steps, but the contribution of individual nucleases to the processing of double-strand DNA ends at different stages of HR has...
Generation of medaka gene knockout models by target-selected mutagenesis
Taniguchi, Yoshihito, Takeda, Shunichi, Furutani-Seiki, Makoto, Kamei, Yasuhiro, Todo, Takeshi, Sasado, Takao, ...
A reverse genetics approach for the routine generation of medaka (Oryzias latipes) gene knockouts is described and applied to create a cryopreserved resource containing knockouts for most medaka...
Saberi, Alihossein, Hochegger, Helfrid, Szuts, David, Lan, Li, Yasui, Akira, Sale, Julian E., ...
The Saccharomyces cerevisiae RAD18 gene is essential for postreplication repair but is not required for homologous recombination (HR), which is the major double-strand break (DSB) repair pathway in...