Onishi, Akishi, Hasegawa, Jun, Imai, Hiroo, Chisaka, Osamu, Ueda, Yoshiki, Honda, Yoshihito, ...
Red-green color vision in primates is unique in the sense that it is mediated by two photoreceptor cells that are indistinguishable in all aspects except for their visual pigments. In order to...
Oh, Hideyasu, Takagi, Hitoshi, Otani, Atsushi, Koyama, Shinji, Kemmochi, Seiji, Uemura, Akiyoshi, ...
Neuropilin (NRP) 1, previously identified as a neuronal receptor that mediates repulsive growth cone guidance, has been shown recently to function also in endothelial cells as an isoform-specific...
Uemura, Akiyoshi, Ogawa, Minetaro, Hirashima, Masanori, Fujiwara, Takashi, Koyama, Shinji, Takagi, Hitoshi, ...
Interactions between endothelial cells (ECs) and perivascular mural cells (MCs) via signaling molecules or physical contacts are implicated both in vascular remodeling and maintenance of vascular...
Honjo, Megumi, Nakamura, Kayo, Yamashiro, Kenji, Kiryu, Junichi, Tanihara, Hidenobu, McEvoy, Leslie M., ...
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major endothelial receptor for oxidized low-density lipoprotein, and is assumed to play a proatherogenic role in atherosclerosis....
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
Ooto, Sotaro, Akagi, Tadamichi, Kageyama, Ryoichiro, Akita, Joe, Mandai, Michiko, Honda, Yoshihito, ...
It has long been believed that the retina of mature mammals is incapable of regeneration. In this study, using the N-methyl-d-aspartate neurotoxicity model of adult rat retina, we observed that some...
Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells
Ikeda, Hanako, Osakada, Fumitaka, Watanabe, Kiichi, Mizuseki, Kenji, Haraguchi, Tomoko, Miyoshi, Hiroyuki, ...
We report directed differentiaion of retinal precursors in vitro from mouse ES cells. Six3+ rostral brain progenitors are generated by culturing ES cells under serum-free suspension conditions (SFEB...
Oh, Hideyasu, Takagi, Hitoshi, Otani, Atsushi, Koyama, Shinji, Kemmochi, Seiji, Uemura, Akiyoshi, ...
Neuropilin (NRP) 1, previously identified as a neuronal receptor that mediates repulsive growth cone guidance, has been shown recently to function also in endothelial cells as an isoform-specific...
Uemura, Akiyoshi, Ogawa, Minetaro, Hirashima, Masanori, Fujiwara, Takashi, Koyama, Shinji, Takagi, Hitoshi, ...
Interactions between endothelial cells (ECs) and perivascular mural cells (MCs) via signaling molecules or physical contacts are implicated both in vascular remodeling and maintenance of vascular...
Honjo, Megumi, Nakamura, Kayo, Yamashiro, Kenji, Kiryu, Junichi, Tanihara, Hidenobu, McEvoy, Leslie M., ...
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major endothelial receptor for oxidized low-density lipoprotein, and is assumed to play a proatherogenic role in atherosclerosis....
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
Ooto, Sotaro, Akagi, Tadamichi, Kageyama, Ryoichiro, Akita, Joe, Mandai, Michiko, Honda, Yoshihito, ...
It has long been believed that the retina of mature mammals is incapable of regeneration. In this study, using the N-methyl-d-aspartate neurotoxicity model of adult rat retina, we observed that some...
Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells
Ikeda, Hanako, Osakada, Fumitaka, Watanabe, Kiichi, Mizuseki, Kenji, Haraguchi, Tomoko, Miyoshi, Hiroyuki, ...
We report directed differentiaion of retinal precursors in vitro from mouse ES cells. Six3+ rostral brain progenitors are generated by culturing ES cells under serum-free suspension conditions (SFEB...
Ojima, Tomonari, Takagi, Hitoshi, Suzuma, Kiyoshi, Oh, Hideyasu, Suzuma, Izumi, Ohashi, Hirokazu, ...
The Eph receptor/ephrin system is a recently discovered regulator of vascular development during embryogenesis. Activation of EphA2, one of the Eph receptors, reportedly suppresses cell proliferation...
Miyahara, Shinsuke, Kiryu, Junichi, Yamashiro, Kenji, Miyamoto, Kazuaki, Hirose, Fumitaka, Tamura, Hiroshi, ...
Leukocytes play important roles in the pathogenesis of diabetic retinopathy. Recently, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors have been reported to exert various effects in...
Watanabe, Daisuke, Takagi, Hitoshi, Suzuma, Kiyoshi, Suzuma, Izumi, Oh, Hideyasu, Ohashi, Hirokazu, ...
Transcription factor Ets-1 has been reported to regulate angiogenesis in vascular endothelial cells. Here, we investigated a mechanism that may regulate the expression of Ets-1 in vascular...
Expression of Thrombospondin-1 in Ischemia-Induced Retinal Neovascularization
Suzuma, Kiyoshi, Takagi, Hitoshi, Otani, Atsushi, Oh, Hideyasu, Honda, Yoshihito
Thrombospondin-1 is an extracellular matrix protein that inhibits endothelial cell proliferation, migration, and angiogenesis. This study was performed to investigate the role of thrombospondin-1 in...
Yamashiro, Kenji, Tsujikawa, Akitaka, Ishida, Susumu, Usui, Tomohiko, Kaji, Yuichi, Honda, Yoshihito, ...
Platelet microthrombi are present in the diabetic retinal vasculature of humans and rodents; however, the mechanisms and consequences of their presence have not been defined. The current study...
Koyama, Shinji, Takagi, Hitoshi, Otani, Atsushi, Suzuma, Kiyoshi, Nishimura, Kazuo, Honda, Yoshihito
Tranilast, first developed as an anti-allergic drug, has been reported to inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis and vasopermeability. To further clarify the...
Inhibitory mechanism of vascular endothelial growth factor (VEGF) by bucillamine
Koyama, Shinji, Takagi, Hitoshi, Otani, Atsushi, Oh, Hideyasu, Nishimura, Kazuo, Honda, Yoshihito
Vascular endothelial growth factor (VEGF) plays an important role in the neovascularization of ischaemic retinal diseases such as proliferative diabetic retinopathy. We determined that bucillamine,...