Lentivirus Vectors Using Human and Simian Immunodeficiency Virus Elements
White, Sarah M., Renda, Matthew, Nam, Na-Yon, Klimatcheva, Ekaterina, Zhu, Yonghong, Fisk, Jennifer, ...
Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to...
Zhu, Yonghong, Gelbard, Harris A., Roshal, Mikhail, Pursell, Shannon, Jamieson, Beth D., Planelles, Vicente
All primate lentiviruses known to date contain one or two open reading frames with homology to the human immunodeficiency virus type 1 (HIV-1) vpr gene. HIV-1 vpr encodes a 96-amino-acid protein with...
Intra-S-Phase Checkpoint Activation by Direct CDK2 Inhibition
Zhu, Yonghong, Alvarez, Carmen, Doll, Ronald, Kurata, Hirokazu, Schebye, Xiao Min, Parry, David, ...
To ensure proper progression through a cell cycle, checkpoints have evolved to play a surveillance role in maintaining genomic integrity. In this study, we demonstrate that loss of CDK2 activity...
Lentivirus Vectors Using Human and Simian Immunodeficiency Virus Elements
White, Sarah M., Renda, Matthew, Nam, Na-Yon, Klimatcheva, Ekaterina, Zhu, Yonghong, Fisk, Jennifer, ...
Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to...
Zhu, Yonghong, Gelbard, Harris A., Roshal, Mikhail, Pursell, Shannon, Jamieson, Beth D., Planelles, Vicente
All primate lentiviruses known to date contain one or two open reading frames with homology to the human immunodeficiency virus type 1 (HIV-1) vpr gene. HIV-1 vpr encodes a 96-amino-acid protein with...
Intra-S-Phase Checkpoint Activation by Direct CDK2 Inhibition
Zhu, Yonghong, Alvarez, Carmen, Doll, Ronald, Kurata, Hirokazu, Schebye, Xiao Min, Parry, David, ...
To ensure proper progression through a cell cycle, checkpoints have evolved to play a surveillance role in maintaining genomic integrity. In this study, we demonstrate that loss of CDK2 activity...
Tbx5-dependent pathway regulating diastolic function in congenital heart disease
Zhu, Yonghong, Gramolini, Anthony O., Walsh, Mark A., Zhou, Yu-Qing, Slorach, Cameron, Friedberg, Mark K., ...
At the end of every heartbeat, cardiac myocytes must relax to allow filling of the heart. Impaired relaxation is a significant factor in heart failure, but all pathways regulating the cardiac...