Yiyang Xia

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

Harrison, Jeffrey K., Jiang, Yan, Chen, Shizong, Xia, Yiyang, Maciejewski, Dominique, McNamara, Robert K., ...

A recently identified chemokine, fractalkine, is a member of the chemokine gene family, which consists principally of secreted, proinflammatory molecules. Fractalkine is distinguished structurally by...

RelB Modulation of IκBα Stability as a Mechanism of Transcription Suppression of Interleukin-1α (IL-1α), IL-1β, and Tumor Necrosis Factor Alpha in Fibroblasts†

Xia, Yiyang, Chen, Shizhong, Wang, Yibin, Mackman, Nigel, Ku, George, Lo, David, ...

Members of the NF-κB/RelB family of transcription factors play important roles in the regulation of inflammatory and immune responses. RelB, a member of this family, has been characterized as a...

Heparin-binding EGF-like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats

Feng, Lili, Garcia, Gabriela E., Yang, Young, Xia, Yiyang, Gabbai, Francis B., Peterson, Orjan W., ...

Heparin-binding epidermal growth factor–like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is expressed during inflammatory and pathological conditions. We have...

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

Harrison, Jeffrey K., Jiang, Yan, Chen, Shizong, Xia, Yiyang, Maciejewski, Dominique, McNamara, Robert K., ...

A recently identified chemokine, fractalkine, is a member of the chemokine gene family, which consists principally of secreted, proinflammatory molecules. Fractalkine is distinguished structurally by...

RelB Modulation of IκBα Stability as a Mechanism of Transcription Suppression of Interleukin-1α (IL-1α), IL-1β, and Tumor Necrosis Factor Alpha in Fibroblasts†

Xia, Yiyang, Chen, Shizhong, Wang, Yibin, Mackman, Nigel, Ku, George, Lo, David, ...

Members of the NF-κB/RelB family of transcription factors play important roles in the regulation of inflammatory and immune responses. RelB, a member of this family, has been characterized as a...

Heparin-binding EGF-like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats

Feng, Lili, Garcia, Gabriela E., Yang, Young, Xia, Yiyang, Gabbai, Francis B., Peterson, Orjan W., ...

Heparin-binding epidermal growth factor–like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is expressed during inflammatory and pathological conditions. We have...

Blocking of Monocyte Chemoattractant Protein-1 during Tubulointerstitial Nephritis Resulted in Delayed Neutrophil Clearance

Li, Ping, Garcia, Gabriela E., Xia, Yiyang, Wu, Wei, Gersch, Christine, Park, Pyong Woo, ...

The chemokine monocyte chemoattractant protein (MCP)-1 has been implicated in the monocyte/macrophage infiltration that occurs during tubulointerstitial nephritis (TIN). We investigated the role of...

Mononuclear Cell-Infiltrate Inhibition by Blocking Macrophage-Derived Chemokine Results in Attenuation of Developing Crescentic Glomerulonephritis

Garcia, Gabriela E., Xia, Yiyang, Harrison, Jeffrey, Wilson, Curtis B., Johnson, Richard J., Bacon, Kevin B., ...

Glomerular monocyte/macrophage (Mo/Mφ) infiltrates play a role in many forms of glomerulonephritis (GN), and the intensity of Mo/Mφ trafficking correlates with the loss of renal function and...

In Vivo Inhibition of CC and CX3C Chemokine–induced Leukocyte Infiltration and Attenuation of Glomerulonephritis in Wistar-Kyoto (WKY) Rats by vMIP-II

Chen, Shizhong, Bacon, Kevin B., Li, Li, Garcia, Gabriela E., Xia, Yiyang, Lo, David, ...

Chemokines play a central role in immune and inflammatory responses. It has been observed recently that certain viruses have evolved molecular piracy and mimicry mechanisms by encoding and...