"Sequencing-grade" screening for BRCA1variants by oligo-arrays (2008)
Monaco, Alessandro, Menolascina, Filippo, Zhao, Yingdong, Tommasi, Stefania, Sabatino, Marianna, Fasano, Ross, ...
Abstract The need for fast, efficient, and less costly means to screen genetic variants associated with disease predisposition led us to develop an oligo-nucleotide array-based process for...
Meade, Kieran G, Gormley, Eamonn, O'Farrelly, Cliona, Park, Stephen D, Costello, Eamon, Keane, Joseph, ...
Abstract Background Bovine tuberculosis (BTB) caused by Mycobacterium bovis continues to cause substantial losses to global agriculture and has significant repercussions for human health. The advent...
Fang, Weiyi, Li, Xin, Jiang, Qingping, Liu, Zhen, Yang, Huiling, Wang, Shuang, ...
Abstract Background The pathogenesis of nasopharyngeal carcinoma (NPC) is a complicated process involving genetic predisposition, Epstein-Bar Virus infection, and genetic alterations. Although some...
The explosion of available microarray data on human cancer increases the urgency for developing methods for effectively sharing this data among clinical cancer investigators. Lack of a smooth...
The explosion of available microarray data on human cancer increases the urgency for developing methods for effectively sharing this data among clinical cancer investigators. Lack of a smooth...
Meade, Kieran G, Gormley, Eamonn, Doyle, Mairéad B, Fitzsimons, Tara, O'Farrelly, Cliona, Costello, Eamon, ...
Abstract Background Bovine tuberculosis is an enduring disease of cattle that has significant repercussions for human health. The advent of high-throughput functional genomics technologies has...
Panelli, Monica C, Stashower, Mitchell E, Slade, Herbert B, Smith, Kina, Norwood, Christopher, Abati, Andrea, ...
Abstract Background Imiquimod is a Toll-like receptor-7 agonist capable of inducing complete clearance of basal cell carcinoma (BCC) and other cutaneous malignancies. We hypothesized that the...
Analysis of Gene Expression Data Using BRB-Array Tools (2007)
Richard Simon, Amy Lam, Ming-Chung Li, Michael Ngan, Supriya Menenzes, Yingdong Zhao
BRB-ArrayTools is an integrated software system for the comprehensive analysis of DNA microarray experiments. It was developed by professional biostatisticians experienced in the design and analysis...
Recognition of Conserved Amino Acid Motifs of Common Viruses and Its Role in Autoimmunity (2005)
Mireia Sospedra, Yingdong Zhao, Harald Zur Hausen, Paolo A. Muraro, Christa Hamashin, ...
The triggers of autoimmune diseases such as multiple sclerosis (MS) remain elusive. Epidemiological studies suggest that common pathogens can exacerbate and also induce MS, but it has been difficult...
An adaptive method for cDNA microarray normalization (2005)
Zhao, Yingdong, Li, Ming-Chung, Simon, Richard
Abstract Background Normalization is a critical step in analysis of gene expression profiles. For dual-labeled arrays, global normalization assumes that the majority of the genes on the array are...
Selection and validation of endogenous reference genes using a high throughput approach (2004)
Jin, Ping, Zhao, Yingdong, Ngalame, Yvonne, Panelli, Monica C, Nagorsen, Dirk, Monsurró, Vladia, ...
Abstract Background Endogenous reference genes are commonly used to normalize expression levels of other genes with the assumption that the expression of the former is constant in different tissues...
Wang, Ena, Adams, Sharon, Zhao, Yingdong, Panelli, Monica, Simon, Richard, Klein, Harvey, ...
Abstract Detection of unknown single nucleotide polymorphism (SNP) relies on large scale sequencing expeditions of genomic fragments or complex high-throughput chip technology. We describe a...
"... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biochemistry and Biophysics."
Huai, Qing, Kim, Hwa-Young, Liu, Yudong, Zhao, Yingdong, Mondragon, Angelo, Liu, Jun O., ...
Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin–immunosuppressant complexes, cyclophilin A–cyclosporin A (CyPA-CsA) and FKBP–FK506. How...
Wang, Ena, Adams, Sharon, Zhao, Yingdong, Panelli, Monica, Simon, Richard, Klein, Harvey, ...
Detection of unknown single nucleotide polymorphism (SNP) relies on large scale sequencing expeditions of genomic fragments or complex high-throughput chip technology. We describe a simplified...
Crystal structure of NaeI—an evolutionary bridge between DNA endonuclease and topoisomerase
Huai, Qing, Colandene, James D., Chen, Yongquan, Luo, Feng, Zhao, Yingdong, Topal, Michael D., ...
NaeI is transformed from DNA endonuclease to DNA topoisomerase and recombinase by a single amino acid substitution. The crystal structure of NaeI was solved at 2.3 Å resolution and shows that NaeI...
Selection and validation of endogenous reference genes using a high throughput approach
Jin, Ping, Zhao, Yingdong, Ngalame, Yvonne, Panelli, Monica C, Nagorsen, Dirk, Monsurró, Vladia, ...
Recognition of Conserved Amino Acid Motifs of Common Viruses and Its Role in Autoimmunity
Sospedra, Mireia, Zhao, Yingdong, Zur Hausen, Harald, Muraro, Paolo A, Hamashin, Christa, De Villiers, Ethel-Michele, ...
The triggers of autoimmune diseases such as multiple sclerosis (MS) remain elusive. Epidemiological studies suggest that common pathogens can exacerbate and also induce MS, but it has been difficult...
Huai, Qing, Kim, Hwa-Young, Liu, Yudong, Zhao, Yingdong, Mondragon, Angelo, Liu, Jun O., ...
Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin–immunosuppressant complexes, cyclophilin A–cyclosporin A (CyPA-CsA) and FKBP–FK506. How...
Wang, Ena, Adams, Sharon, Zhao, Yingdong, Panelli, Monica, Simon, Richard, Klein, Harvey, ...
Detection of unknown single nucleotide polymorphism (SNP) relies on large scale sequencing expeditions of genomic fragments or complex high-throughput chip technology. We describe a simplified...
Crystal structure of NaeI—an evolutionary bridge between DNA endonuclease and topoisomerase
Huai, Qing, Colandene, James D., Chen, Yongquan, Luo, Feng, Zhao, Yingdong, Topal, Michael D., ...
NaeI is transformed from DNA endonuclease to DNA topoisomerase and recombinase by a single amino acid substitution. The crystal structure of NaeI was solved at 2.3 Å resolution and shows that NaeI...
Selection and validation of endogenous reference genes using a high throughput approach
Jin, Ping, Zhao, Yingdong, Ngalame, Yvonne, Panelli, Monica C, Nagorsen, Dirk, Monsurró, Vladia, ...
Recognition of Conserved Amino Acid Motifs of Common Viruses and Its Role in Autoimmunity
Sospedra, Mireia, Zhao, Yingdong, Zur Hausen, Harald, Muraro, Paolo A, Hamashin, Christa, De Villiers, Ethel-Michele, ...
The triggers of autoimmune diseases such as multiple sclerosis (MS) remain elusive. Epidemiological studies suggest that common pathogens can exacerbate and also induce MS, but it has been difficult...
Panelli, Monica C, Stashower, Mitchell E, Slade, Herbert B, Smith, Kina, Norwood, Christopher, Abati, Andrea, ...
An analysis of basal cell carcinoma subjected to local application of imiquimod revealed that most transcripts stimulated by imiquimod involve the activation of cellular innate and adaptive...
Nambiar, Ashok, Duquesnoy, Rene J., Adams, Sharon, Zhao, Yingdong, Oblitas, Jaime, Leitman, Susan, ...
This study describes a novel application of HLAMatchmaker to determine platelet compatibility in 16 alloimmunized patients with aplastic anemia refractory to random donor platelet transfusions....
Meade, Kieran G, Gormley, Eamonn, Doyle, Mairéad B, Fitzsimons, Tara, O'Farrelly, Cliona, Costello, Eamon, ...
Meade, Kieran G, Gormley, Eamonn, O'Farrelly, Cliona, Park, Stephen D, Costello, Eamon, Keane, Joseph, ...
"Sequencing-grade" screening for BRCA1 variants by oligo-arrays
Monaco, Alessandro, Menolascina, Filippo, Zhao, Yingdong, Tommasi, Stefania, Sabatino, Marianna, Fasano, Ross, ...
The need for fast, efficient, and less costly means to screen genetic variants associated with disease predisposition led us to develop an oligo-nucleotide array-based process for gene-specific...