Yasodha Natkunam

Immunoblot Analysis of CD34 Expression in Histologically Diverse Neoplasms

Natkunam, Yasodha, Rouse, Robert V., Zhu, Shirley, Fisher, Cyril, Van De Rijn, Matthijs

CD34 is a heavily glycosylated transmembrane protein of ∼110 kd whose function is essentially uncharacterized. First identified in a myeloid leukemia cell line, immunohistological reactivity with...

Software Tools for High-Throughput Analysis and Archiving of Immunohistochemistry Staining Data Obtained with Tissue Microarrays

Liu, Chih Long, Prapong, Wijan, Natkunam, Yasodha, Alizadeh, Ash, Montgomery, Kelli, Gilks, C. Blake, ...

The creation of tissue microarrays (TMAs) allows for the rapid immunohistochemical analysis of thousands of tissue samples, with numerous different antibodies per sample. This technical development...

Expression of the human germinal center–associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation

Natkunam, Yasodha, Lossos, Izidore S., Taidi, Behnaz, Zhao, Shuchun, Lu, XiaoQing, Ding, Feying, ...

We identified the human germinal center-associated lymphoma (HGAL) in gene-expression profiling studies of diffuse large B-cell lymphoma (DLBCL). The expression of HGAL correlated with survival in...

Microvessel Density and Expression of Vascular Endothelial Growth Factor and Its Receptors in Diffuse Large B-Cell Lymphoma Subtypes

Gratzinger, Dita, Zhao, Shuchun, Marinelli, Robert J., Kapp, Amy V., Tibshirani, Robert J., Hammer, Anne S., ...

Angiogenesis is known to play a major role in neoplasia, including hematolymphoid neoplasia. We assessed the relationships among angiogenesis and expression of vascular endothelial growth factor and...

Oncogenic Regulators and Substrates of the Anaphase Promoting Complex/Cyclosome Are Frequently Overexpressed in Malignant Tumors

Lehman, Norman L., Tibshirani, Rob, Hsu, Jerry Y., Natkunam, Yasodha, Harris, Brent T., West, Robert B., ...

The fidelity of cell division is dependent on the accumulation and ordered destruction of critical protein regulators. By triggering the appropriately timed, ubiquitin-dependent proteolysis of the...

Expression of the human germinal center–associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival

Natkunam, Yasodha, Hsi, Eric D., Aoun, Patricia, Zhao, Shuchun, Elson, Paul, Pohlman, Brad, ...

The human germinal-center–associated lymphoma (HGAL) gene and its cognate protein are expressed in a germinal center (GC)–specific manner. Its expression in classic Hodgkin lymphoma (cHL)...

The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas

Natkunam, Yasodha, Zhao, Shuchun, Mason, David Y., Chen, Jun, Taidi, Behnaz, Jones, Margaret, ...

We previously developed a multivariate model based on the RNA expression of 6 genes (LMO2, BCL6, FN1, CCND2, SCYA3, and BCL2) that predicts survival in diffuse large B-cell lymphoma (DLBCL) patients....

The Stanford Tissue Microarray Database

Marinelli, Robert J., Montgomery, Kelli, Liu, Chih Long, Shah, Nigam H., Prapong, Wijan, Nitzberg, Michael, ...

The Stanford Tissue Microarray Database (TMAD; http://tma.stanford.edu) is a public resource for disseminating annotated tissue images and associated expression data. Stanford University...