Hongzhe Li, Ninning Liu, Grace K. Rajendran, Thomas J. Gernon, Jason K. Rockhill, Jeffrey L. Schwartz, ...
Li, H., Liu, N., Rajendran, G. K., Gernon, T. J., Rockhill, J. K., Schwartz, J. L. and Gu, Y. A Role for Endogenous and Radiation-Induced DNA Double-Strand Breaks in p53-Dependent Apoptosis during...
Li, Hongzhe, Rajendran, Grace K, Liu, Ninning, Ware, Carol, Rubin, Brian P, Gu, Yansong
Abstract Introduction Estrogen and insulin-like growth factor-1 (IGF-1) play important roles in mammary gland development and breast cancer. SirT1 is a highly conserved protein deacetylase that can...
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Gu, Yansong, Sekiguchi, JoAnn, Gao, Yijie, Dikkes, Pieter, Frank, Karen, Ferguson, David, ...
Mammalian nonhomologous DNA end joining employs Ku70, Ku80, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), XRCC4, and DNA ligase IV (Lig4). Herein, we show that Ku70 and Ku80 deficiency...
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice
Borghesani, Paul R., Alt, Frederick W., Bottaro, Andrea, Davidson, Laurie, Aksoy, Saime, Rathbun, Gary A., ...
Motor incoordination, immune deficiencies, and an increased risk of cancer are the characteristic features of the hereditary disease ataxia–telangiectasia (A-T), which is caused by mutations in the...
Gu, Yansong, Jin, Shengfang, Gao, Yijie, Weaver, David T., Alt, Frederick W.
V(D)J recombination requires both lymphoid-specific and generally expressed enzymatic activities. All three known generally expressed activities involved in V(D)J recombination are also involved in...
Sekiguchi, JoAnn, Ferguson, David O., Chen, Hua Tang, Yang, Eva Mary, Earle, John, Frank, Karen, ...
DNA ligase IV (Lig4) and the DNA-dependent protein kinase (DNA-PK) function in nonhomologous end joining (NHEJ). However, although Lig4 deficiency causes late embryonic lethality, deficiency in...
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
Cheng, Hwei-Ling, Mostoslavsky, Raul, Saito, Shin'ichi, Manis, John P., Gu, Yansong, Patel, Parin, ...
SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor Sir2. Dominant-negative and overexpression studies have implicated a role for SIRT1 in deacetylating the p53...
Gu, Yansong, Sekiguchi, JoAnn, Gao, Yijie, Dikkes, Pieter, Frank, Karen, Ferguson, David, ...
Mammalian nonhomologous DNA end joining employs Ku70, Ku80, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), XRCC4, and DNA ligase IV (Lig4). Herein, we show that Ku70 and Ku80 deficiency...
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice
Borghesani, Paul R., Alt, Frederick W., Bottaro, Andrea, Davidson, Laurie, Aksoy, Saime, Rathbun, Gary A., ...
Motor incoordination, immune deficiencies, and an increased risk of cancer are the characteristic features of the hereditary disease ataxia–telangiectasia (A-T), which is caused by mutations in the...
Gu, Yansong, Jin, Shengfang, Gao, Yijie, Weaver, David T., Alt, Frederick W.
V(D)J recombination requires both lymphoid-specific and generally expressed enzymatic activities. All three known generally expressed activities involved in V(D)J recombination are also involved in...
Sekiguchi, JoAnn, Ferguson, David O., Chen, Hua Tang, Yang, Eva Mary, Earle, John, Frank, Karen, ...
DNA ligase IV (Lig4) and the DNA-dependent protein kinase (DNA-PK) function in nonhomologous end joining (NHEJ). However, although Lig4 deficiency causes late embryonic lethality, deficiency in...
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
Cheng, Hwei-Ling, Mostoslavsky, Raul, Saito, Shin'ichi, Manis, John P., Gu, Yansong, Patel, Parin, ...
SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor Sir2. Dominant-negative and overexpression studies have implicated a role for SIRT1 in deacetylating the p53...
Deletion of Ku70, Ku80, or Both Causes Early Aging without Substantially Increased Cancer▿
Li, Han, Vogel, Hannes, Holcomb, Valerie B., Gu, Yansong, Hasty, Paul
Ku70 forms a heterodimer with Ku80, called Ku, that is critical for repairing DNA double-stand breaks by nonhomologous end joining and for maintaining telomeres. Mice with either gene mutated exhibit...
Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching
Manis, John P., Gu, Yansong, Lansford, Rusty, Sonoda, Eiichiro, Ferrini, Roger, Davidson, Laurie, ...
Immunoglobulin (Ig) heavy chain (HC) class switch recombination (CSR) is a late B cell process that involves intrachromosomal DNA rearrangement. Ku70 and Ku80 form a DNA end-binding complex required...