Elkon, Ran, Rashi-Elkeles, Sharon, Lerenthal, Yaniv, Linhart, Chaim, Tenne, Tamar, Amariglio, Ninette, ...
Abstract Background Gene-expression microarrays and RNA interferences (RNAi) are among the most prominent techniques in functional genomics. The combination of the two holds promise for systematic,...
Requirement of the MRN complex for ATM activation by DNA damage
Uziel, Tamar, Lerenthal, Yaniv, Moyal, Lilach, Andegeko, Yair, Mittelman, Leonid, Shiloh, Yosef
The ATM protein kinase is a primary activator of the cellular response to DNA double-strand breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in various branches of...
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
Lukas, Claudia, Melander, Fredrik, Stucki, Manuel, Falck, Jacob, Bekker-Jensen, Simon, Goldberg, Michal, ...
Mdc1/NFBD1 controls cellular responses to DNA damage, in part via interacting with the Mre11–Rad50–Nbs1 complex that is involved in the recognition, signalling, and repair of DNA double-strand...
Elkon, Ran, Rashi-Elkeles, Sharon, Lerenthal, Yaniv, Linhart, Chaim, Tenne, Tamar, Amariglio, Ninette, ...
Microarray and RNAi technologies were applied to dissect a transcriptional network induced by DNA damage in human cells, revealing that two pivotal stress-induced transcription factors (NFκB and...
Requirement of the MRN complex for ATM activation by DNA damage
Uziel, Tamar, Lerenthal, Yaniv, Moyal, Lilach, Andegeko, Yair, Mittelman, Leonid, Shiloh, Yosef
The ATM protein kinase is a primary activator of the cellular response to DNA double-strand breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in various branches of...
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
Lukas, Claudia, Melander, Fredrik, Stucki, Manuel, Falck, Jacob, Bekker-Jensen, Simon, Goldberg, Michal, ...
Mdc1/NFBD1 controls cellular responses to DNA damage, in part via interacting with the Mre11–Rad50–Nbs1 complex that is involved in the recognition, signalling, and repair of DNA double-strand...
Elkon, Ran, Rashi-Elkeles, Sharon, Lerenthal, Yaniv, Linhart, Chaim, Tenne, Tamar, Amariglio, Ninette, ...
Microarray and RNAi technologies were applied to dissect a transcriptional network induced by DNA damage in human cells, revealing that two pivotal stress-induced transcription factors (NFκB and...
Blank, Michael, Lerenthal, Yaniv, Mittelman, Leonid, Shiloh, Yosef
Mitotic cell death (MCD) is a prominent but poorly defined form of death that stems from aberrant mitosis. One of the early steps in MCD is premature mitosis and uneven chromatin condensation (UCC)....
Alberstein, Moti, Amit, Maayan, Vaknin, Keren, O'Donnell, Amanda, Farhy, Chen, Lerenthal, Yaniv, ...
Alternative splicing plays a major role in transcriptome diversity and plasticity, but it is largely unknown how tissue-specific and embryogenesis-specific alternative splicing is regulated. The...