Yan Zhang

Frequent RASSF1A gene promoter hypermethylation in breast cancer (2008)

Zhang, Yan

RASSF1A identified at 3p21.3 was suggested as the major target tumor suppressor on the basis of its frequent epigenetic silencing in human cancers, including breast cancer. We performed a...

Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective (2008)

Liu, Jinfeng, Zhang, Yan, Lei, Xingye, Zhang, Zemin

Abstract Background The rates of molecular evolution for protein-coding genes depend on the stringency of functional or structural constraints. The Ka/Ks ratio has been commonly used as an indicator...

Molybdoproteomes and evolution of molybdenum utilization (2008)

Zhang, Yan, Gladyshev, Vadim N.

The trace element molybdenum (Mo) is utilized in many life forms, where it is a key component of several enzymes involved in nitrogen, sulfur, and carbon metabolism. With the exception of...

Analysis of tall fescue ESTs representing different abiotic stresses, tissue types and developmental stages (2008)

Mian, MA Rouf, Zhang, Yan, Wang, Zeng-Yu, Zhang, Ji-Yi, Cheng, Xiaofei, Chen, Lei, ...

Abstract Background Tall fescue ( Festuca arundinacea Schreb) is a major cool season forage and turf grass species grown in the temperate regions of the world. In this paper we report the generation...

An Algebraic Characterization of Security of Cryptographic Protocols (2008)

Patra, Manas K, Zhang, Yan

Several of the basic cryptographic constructs have associated algebraic structures. Formal models proposed by Dolev and Yao to study the (unconditional) security of public key protocols form a group....

Combined Hepatocellular Cholangiocarcinomas; Analysis of a Large Database (2008)

Mitchell S. Wachtel, Yan Zhang, Tom Xu, Maurizio Chiriva-Internati, Eldo E Frezza

Aim: Combined hepatocellular cholangiocarcinoma (combined tumor) has been described as either a variant of hepatoma or a variant of cholangiocarcinoma. Prior studies evaluated fewer than 50 patients...

Diacetonitrile[N,N′-bis(3,4,5-trimethoxybenzylidene)ethylenediamine]copper(I) perchlorate (2008)

Aliakbar Dehno Khalaji, Korbanjhon Brad, Yan Zhang

In the title compound, [Cu(C2H3N)2(C22H28N2O6)]ClO4, the Cu atom is coordinated by two N atoms from one bidentate Schiff base ligand and two N atoms from two acetonitrile groups. The Cu atom adopts a...

1,1′-Biphenyl-2,3,3′,4′-tetracarboxylic acid monohydrate (2008)

Yan Jiang, Jian Men, Chong-Yi Liu, Yan Zhang, Guo-Wei Gao

In the organic molecule of the title compound, C16H10O8·H2O, the dihedral angle between the two benzene rings is 42.30 (11)°. Extensive O—H...O hydrogen bonding helps to...

Pancreas Cancer Survival in the Gemcitabine Era (2008)

Mitchell S. Wachtel, K. Tom Xu, Yan Zhang, Maurizio Chiriva-Internati, Eldo E. Frezza

After multiple positive studies, gemcitabine, approved for the treatment of pancreas cancer by the FDA in 1977, became standard of care. Whether this therapeutic advance has translated into longer...

Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-α mice (2007)

Dogan, Soner, Hu, Xin, Zhang, Yan, Maihle, Nita J, Grande, Joseph P, Cleary, Margot P

Abstract Introduction Obesity is a risk factor for postmenopausal breast cancer and is associated with shortened mammary tumor (MT) latency in MMTV-TGF-α mice with dietary-induced obesity. One link...

Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life (2007)

Lobanov, Alexey V., Fomenko, Dmitri E., Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L., Gladyshev, Vadim N.

Background: Selenocysteine (Sec) is a selenium-containing amino acid that is co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both eukaryotes and...

Quantum dot imaging for embryonic stem cells (2007)

Lin, Shuan, Xie, Xiaoyan, Patel, Manishkumar R, Yang, Yao-Hung, Li, Zongjin, Cao, Feng, ...

Abstract Background Semiconductor quantum dots (QDs) hold increasing potential for cellular imaging both in vitro and in vivo . In this report, we aimed to evaluate in vivo multiplex imaging of mouse...

New Developments in Selenium Biochemistry: Selenocysteine Biosynthesis in Eukaryotes and Archaea (2007)

Xu, Xue-Ming, Carlson, Bradley A., Zhang, Yan, Mix, Heiko, Kryukov, Gregory V., Glass, Richard S., ...

We used comparative genomics and experimental analyses to show that (1) eukaryotes and archaea, which possess the selenocysteine (Sec) protein insertion machinery contain an enzyme,...

Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life (2007)

Lobanov, Alexey V, Fomenko, Dmitri E, Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L, Gladyshev, Vadim N

Abstract Background Selenocysteine (Sec) is a selenium-containing amino acid that is co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both...

Community Structure in Congressional Cosponsorship Networks (2007)

Zhang, Yan, Friend, A. J., Traud, Amanda L., Porter, Mason A., Fowler, James H., Mucha, Peter J.

We study the United States Congress by constructing networks between Members of Congress based on the legislation that they cosponsor. Using the concept of modularity, we identify the community...

Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model (2007)

Zhang, Yan, Pu, Xiaoyun, Shi, Ming, Chen, Liyong, Song, Yuhua, Qian, Lu, ...

Abstract Background c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer. Recently, it has been reported that overexpression of c-Jun in breast cancer cell line MCF-7...

High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis (2007)

Zhang, Yan, Gladyshev, Vadim N.

Selenocysteine (Sec) and pyrrolysine (Pyl) are rare amino acids that are cotranslationally inserted into proteins and known as the 21st and 22nd amino acids in the genetic code. Sec and Pyl are...

Biosynthesis of Selenocysteine on Its tRNA in Eukaryotes (2007)

Xu, Xue-Ming, Carlson, Bradley A., Mix, Heiko, Zhang, Yan, Saira, Kazima, Glass, Richard S., ...

Selenocysteine (Sec) is cotranslationally inserted into protein in response to UGA codons and is the 21st amino acid in the genetic code. However, the means by which Sec is synthesized in eukaryotes...

Dynamic programming speedups (2007)

Zhang, Yan

Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2007

Power-aware design in modern computing systems / (2007)

Zhang, Yan.

Thesis (Ph. D.)--University of Virginia, 2007.

Improving the efficiency of graph-based data mining with application to public health data (2007)

Zhang, Yan.

Thesis (M.S. in computer science)--Washington State University, December 2007.

Dynamic programming speedups / (2007)

Zhang, Yan.

Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2007.

Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues (2006)

Zhang, Yan, Romero, Hector, Salinas, Gustavo, Gladyshev, Vadim

Background: Selenocysteine (Sec) is co-translationally inserted into protein in response to UGA codons. It occurs in oxidoreductase active sites and often is catalytically superior to cysteine (Cys)....

Characterization of mitochondrial carrier proteins, Mrs3p, Mrs4p in rapid, high affinity iron transport into mitochondria and frataxin in providing mitochondrial iron for heme and iron sulfur cluster biosynthesis (2006)

Zhang, Yan

Mitochondrial iron is required for the biosynthesis of Fe-S clusters and heme, critical enzyme cofactors. We sought to characterize the mechanism of iron entry into mitochondria for Fe-S cluster and...

Miniature fiber-optic multicavity Fabry-Perot interferometric biosensor (2005)

Zhang, Yan

Fiber-optic Fabry-Perot interferometric (FFPI) sensors have been widely used due to their high sensitivity, ease of fabrication, miniature size, and capability for multiplexing. However, direct...

Magnetic properties in a partially oxidized nanocomposite of Cu-CuCl (2005)

Li, Qi, Zhang, Shi-Wei, Zhang, Yan, Chen, Chinping

Magnetism of a very thin antiferromagnetic (AFM) surface CuO has been investigated with the partially oxidized nanocomposites of Cu-CuCl, ~ 200 nm. The samples are characterized by X-ray diffraction,...

Evolution of selenium utilization traits (2005)

Romero, Hector, Zhang, Yan, Gladyshev, Vadim, Salinas, Gustavo

Background: The essential trace element selenium is used in a wide variety of biological processes. Selenocysteine (Sec), the 21st amino acid, is co-translationally incorporated into a restricted set...

Pyrrolysine and Selenocysteine Use Dissimilar Decoding Strategies (2005)

Zhang, Yan, Baranov, Pavel V., Atkins, John F., Gladyshev, Vadim N.

Selenocysteine (Sec) and pyrrolysine (Pyl) are known as the 21st and 22nd amino acids in protein. Both are encoded by codons that normally function as stop signals. Sec specification by UGA codons...

The microbial selenoproteome of the Sargasso Sea (2005)

Zhang, Yan, Fomenko, Dmitri E., Gladyshev, Vadim

Background: Selenocysteine (Sec) is a rare amino acid which occurs in proteins in major domains of life. It is encoded by TGA, which also serves as the signal for termination of translation,...

Solving logic program conflicts through strong and weak forgettings (2005)

Zhang, Yan, Foo, Norman, Wang, Kewen, L. Kaelbling, A. Saffiotti, L. Kaelbling, A. Saffiotti

We consider how to forget a set of atoms in a logic program. Intuitively, when a set of atoms is forgotten from a logic program, all atoms in the set should be eliminated from this program in some...

Nested epistemic logic programs (2005)

Wang, Kewen, Zhang, Yan

Nested logic programs and epistemic logic programs are two important extensions of answer set programming. However, the relationship between these two formalisms is rarely explored. In this paper we...

Solving logic program conflicts through strong and weak forgettings (2005)

Zhang, Yan, Foo, Norman, Wang, Kewen

We consider how to forget a set of atoms in a logic program. Intuitively, when a set of atoms is forgotten from a logic program, all atoms in the set should be eliminated from this program in some...

Nested epistemic logic programs (2005)

Wang, Kewen, Zhang, Yan

Nested logic programs and epistemic logic programs are two important extensions of answer set programming. However, the relationship between these two formalisms is rarely explored. In this paper we...

Solving logic program conflicts through strong and weak forgettings (2005)

Zhang, Yan, Foo, Norman, Wang, Kewen

We consider how to forget a set of atoms in a logic program. Intuitively, when a set of atoms is forgotten from a logic program, all atoms in the set should be eliminated from this program in some...

Nested epistemic logic programs (2005)

Wang, Kewen, Zhang, Yan

Nested logic programs and epistemic logic programs are two important extensions of answer set programming. However, the relationship between these two formalisms is rarely explored. In this paper we...

Link adaptation schemes for MIMO wireless systems (2005)

Zhang, Yan.

Thesis (Ph. D.)--University of California, San Diego, 2005.

A method to predict reverberation time in concert hall preliminary design stage (2005)

Zhang, Yan.

Thesis (Ph. D.)--Architecture, Georgia Institute of Technology, 2006.

Design and characterization of micro-scale refrigerators and heaters / (2005)

Zhang, Yan.

Thesis (Ph.D.)-University of California, Santa Cruz, 2005.

Influence of biomass burning aerosol on land-atmosphere interactions over Amazonia (2005)

Zhang, Yan.

Thesis (M. S.)--Earth and Atmospheric Sciences, Georgia Institute of Technology, 2006.

Monopulse radar based on spatiotemporal correlation of stochastic signals (2004)

Zhang, Yan

Random noise radar has been applied successfully to range measurement, velocity estimation, and terrain/target imaging. Based on the previous work, this dissertation develops a new approach towards...

Reasoning about Knowledge by Variable Forgetting (2004)

Su, Kaile, Lv, Guanfen, Zhang, Yan

In this paper, we investigate knowledge reasoning within a simple framework called {\it knowledge structure}. We use {\it variable forgetting} as a basic operation for one agent to reason about its...

Reasoning about Knowledge by Variable Forgetting (2004)

Su, Kaile, Lv, Guanfen, Zhang, Yan

In this paper, we investigate knowledge reasoning within a simple framework called {\it knowledge structure}. We use {\it variable forgetting} as a basic operation for one agent to reason about its...

Reasoning about Knowledge by Variable Forgetting (2004)

Su, Kaile, Lv, Guanfen, Zhang, Yan

In this paper, we investigate knowledge reasoning within a simple framework called {\it knowledge structure}. We use {\it variable forgetting} as a basic operation for one agent to reason about its...

Do speculative short sellers detect earnings management? (2004)

Zhang, Yan.

Thesis (Ph. D.)--Louisiana State University, Baton Rouge, 2004.

Handling Defeasibilities in Action Domains (2002)

Zhang, Yan

Representing defeasibility is an important issue in common sense reasoning. In reasoning about action and change, this issue becomes more difficult because domain and action related defeasible...

Two results for proiritized logic programming (2002)

Zhang, Yan

Prioritized default reasoning has illustrated its rich expressiveness and flexibility in knowledge representation and reasoning. However, many important aspects of prioritized default reasoning have...

Cell proliferation and pattern formation in Drosophila oogenesis (2001)

Zhang, Yan

The Hedgehog (Hh) signaling pathway plays important roles in cell proliferation and pattern formation in many organisms including Drosophila and humans. Our studies showed that in Drosophila...

The ACT3 gene and epigenetics. (1997)

Zhang, Yan.

The study of epigenetics is important because it provides insight into differentiation and development. The general model for position effect variegation one of the most well-characterized epigenetic...

Weakly first-order phase transitions: the epsilon expansion vs. numerical simulations (1996)

Arnold, Peter, Sharpe, Stephen R., Yaffe, Laurence G., Zhang, Yan

Some phase transitions of cosmological interest may be weakly first-order and cannot be analyzed by a simple perturbative expansion around mean field theory. We propose a simple two-scalar model--the...

Monte Carlo study of very weak first-order transitions in the three-dimensional Ashkin-Teller model (1996)

Arnold, Peter, Zhang, Yan

We propose numerical simulations of the Ashkin-Teller model as a foil for theoretical techniques for studying very weakly first-order phase transitions in three dimensions. The Ashkin-Teller model is...

$\epsilon$ expansion analysis of very weak first-order transitions in the cubic anisotropy model, Part II (1996)

Arnold, Peter, Zhang, Yan

A companion article analyzed very weakly first-order phase transitions in the cubic anisotropy model using $\eps$ expansion techniques. We extend that analysis to a calculation of the relative...

Chemopreventive effects of sandalwood oil on skin tumor development in mice / (1996)

Zhang, Yan.

Thesis (M.S.)--Pharmaceutical Sciences Dept., South Dakota State University, 1996.

Dynamic properties of combined MDOF primary and MDOF secondary systems / (1988)

Zhang, Yan.

Thesis (M.S.)--Michigan State University. Dept. of Civil and Environmental Engineering, 1988.

The MinE ring required for proper placement of the division site is a mobile structure that changes its cellular location during the Escherichia coli division cycle

Fu, Xiaoli, Shih, Yu-Ling, Zhang, Yan, Rothfield, Lawrence I.

Placement of the division site at midcell in Escherichia coli requires the MinE protein. MinE acts by imparting topological specificity to the MinCD division inhibitor, preventing the inhibitor from...

A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system

Zhang, Yan, Zhou, Li, Miller, Carol A.

The mitogen-activated kinase activating death domain protein (MADD) that is differentially expressed in neoplastic vs. normal cells (DENN) was identified as a substrate for c-Jun N-terminal kinase 3,...

Pharmacological analysis of cyclooxygenase-1 in inflammation

Smith, Christopher J., Zhang, Yan, Koboldt, Carol M., Muhammad, Jerry, Zweifel, Ben S., Shaffer, Alex, ...

The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. These lipid mediators...

Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis

Zhang, Yan, Wang, Hua, Toratani, Shigeaki, Sato, J. Denry, Kan, Mikio, McKeehan, Wallace L., ...

We have reported that normal human salivary gland-derived epithelial cells exclusively express keratinocyte growth factor receptor (KGFR). In the process of malignant transformation of human salivary...

Influence of Outer Surface Protein A Antibody on Borrelia burgdorferi within Feeding Ticks

De Silva, Aravinda M., Zeidner, Nordin S., Zhang, Yan, Dolan, Marc C., Piesman, Joseph, Fikrig, Erol

Borrelia burgdorferi, the spirochetal agent of Lyme disease, is transmitted by Ixodes ticks. When an infected nymphal tick feeds on a host, the bacteria increase in number within the tick, after...

Escherichia coli K1 aslA Contributes to Invasion of Brain Microvascular Endothelial Cells In Vitro and In Vivo

Hoffman, Jill A., Badger, Julie L., Zhang, Yan, Huang, Sheng-He, Kim, Kwang Sik

Neonatal Escherichia coli meningitis remains a devastating disease, with unacceptably high morbidity and mortality despite advances in supportive care measures and bactericidal antibiotics. To...

Transcriptional Analysis of Essential Genes of the Escherichia coli Fatty Acid Biosynthesis Gene Cluster by Functional Replacement with the Analogous Salmonella typhimurium Gene Cluster

Zhang, Yan, Cronan, John E.

The genes encoding several key fatty acid biosynthetic enzymes (called the fab cluster) are clustered in the order plsX-fabH-fabD-fabG-acpP-fabF at min 24 of the Escherichia coli chromosome. A...

Cloning of the Gene Encoding the 44-Kilodalton Antigen of the Agent of Human Granulocytic Ehrlichiosis and Characterization of the Humoral Response

Ijdo, Jacob W., Sun, Wei, Zhang, Yan, Magnarelli, Louis A., Fikrig, Erol

Antibodies in the sera of patients with human granulocytic ehrlichiosis (HGE) commonly recognize a 44-kDa antigen. We cloned the gene encoding the 44-kDa protein of the agent of HGE (aoHGE) by...

Correlation between chromatin association and transcriptional regulation for the Act3p/Arp4 nuclear actin-related protein of Saccharomyces cerevisiae

Harata, Masahiko, Zhang, Yan, Stillman, David J., Matsui, Daisuke, Oma, Yukako, Nishimori, Katsuhiko, ...

Actin-related proteins (Arps), which share a basal structure with actin but have distinct functions, have been found in a wide variety of organisms. While their functions are not yet clear, some Arps...