Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase
Nathan, Lauren, Shi, Weibin, Dinh, Hillary, Mukherjee, Tapan K., Wang, Xuping, Lusis, Aldons J., ...
The effects of testosterone on early atherogenesis and the role of aromatase, an enzyme that converts testosterone to estrogens, were assessed in low density lipoprotein receptor-deficient male mice...
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
Joseph, Sean B., McKilligin, Elaine, Pei, Liming, Watson, Michael A., Collins, Alan R., Laffitte, Bryan A., ...
The nuclear receptors LXRα and LXRβ have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux...
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
Tangirala, Rajendra K., Bischoff, Eric D., Joseph, Sean B., Wagner, Brandee L., Walczak, Robert, Laffitte, Bryan A., ...
Recent studies have identified the liver X receptors (LXRα and LXRβ) as important regulators of cholesterol metabolism and transport. LXRs control transcription of genes critical to a range of...
Increased atherosclerosis in myeloperoxidase-deficient mice
Brennan, Marie-Luise, Anderson, Melissa M., Shih, Diana M., Qu, Xiao-Dan, Wang, Xuping, Mehta, Asha C., ...
Myeloperoxidase (MPO), a heme enzyme secreted by activated phagocytes, generates an array of oxidants proposed to play critical roles in host defense and local tissue damage. Both MPO and its...
Complex Inheritance of the 5-Lipoxygenase Locus Influencing Atherosclerosis in Mice
Ghazalpour, Anatole, Wang, Xuping, Lusis, Aldons J., Mehrabian, Margarete
We previously mapped a locus on chromosome 6 with a large effect (LOD > 6) on aortic lesion size in a (C57BL/6J × CAST/Ei) F2 cross and identified arachidonate 5-lipoxygenase (5LO) as a candidate...
Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase
Nathan, Lauren, Shi, Weibin, Dinh, Hillary, Mukherjee, Tapan K., Wang, Xuping, Lusis, Aldons J., ...
The effects of testosterone on early atherogenesis and the role of aromatase, an enzyme that converts testosterone to estrogens, were assessed in low density lipoprotein receptor-deficient male mice...
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
Joseph, Sean B., McKilligin, Elaine, Pei, Liming, Watson, Michael A., Collins, Alan R., Laffitte, Bryan A., ...
The nuclear receptors LXRα and LXRβ have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux...
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
Tangirala, Rajendra K., Bischoff, Eric D., Joseph, Sean B., Wagner, Brandee L., Walczak, Robert, Laffitte, Bryan A., ...
Recent studies have identified the liver X receptors (LXRα and LXRβ) as important regulators of cholesterol metabolism and transport. LXRs control transcription of genes critical to a range of...
Increased atherosclerosis in myeloperoxidase-deficient mice
Brennan, Marie-Luise, Anderson, Melissa M., Shih, Diana M., Qu, Xiao-Dan, Wang, Xuping, Mehta, Asha C., ...
Myeloperoxidase (MPO), a heme enzyme secreted by activated phagocytes, generates an array of oxidants proposed to play critical roles in host defense and local tissue damage. Both MPO and its...
Complex Inheritance of the 5-Lipoxygenase Locus Influencing Atherosclerosis in Mice
Ghazalpour, Anatole, Wang, Xuping, Lusis, Aldons J., Mehrabian, Margarete
We previously mapped a locus on chromosome 6 with a large effect (LOD > 6) on aortic lesion size in a (C57BL/6J × CAST/Ei) F2 cross and identified arachidonate 5-lipoxygenase (5LO) as a candidate...
Bradley, Michelle N., Hong, Cynthia, Chen, Mingyi, Joseph, Sean B., Wilpitz, Damien C., Wang, Xuping, ...
Liver X receptors (LXRs) α and β are transcriptional regulators of cholesterol homeostasis and potential targets for the development of antiatherosclerosis drugs. However, the specific roles of...
Meng, Haijin, Vera, Iset, Che, Nam, Wang, Xuping, Wang, Susanna S., Ingram-Drake, Leslie, ...
The genetic factors contributing to the complex disorder of myocardial calcification are largely unknown. Using a mouse model, we fine-mapped the major locus (Dyscalc1) contributing to the dystrophic...