Scientific Commons: Xinghua Guo

Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p (2007)

Suter, Bernhard, Pogoutse, Oxana, Guo, Xinghua, Krogan, Nevan, Lewis, Peter, Greenblatt, Jack F, ...

Abstract Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone...

Ryanodine sensitizes the cardiac Ca2+ release channel (ryanodine receptor isoform 2) to Ca2+ activation and dissociates as the channel is closed by Ca2+ depletion

Du, Guo Guang, Guo, Xinghua, Khanna, Vijay K., MacLennan, David H.

In single-channel recordings, the rabbit cardiac Ca2+ release channel (RyR2) is converted to a fully open subconductance state with about 50% of full conductance by micromolar concentrations of...

Central core disease mutations R4892W, I4897T and G4898E in the ryanodine receptor isoform 1 reduce the Ca2+ sensitivity and amplitude of Ca2+-dependent Ca2+ release

Du, Guo Guang, Khanna, Vijay K., Guo, Xinghua, MacLENNAN, David H.

Three CCD (central core disease) mutants, R4892W (Arg4892→Trp), I4897T and G4898E, in the pore region of the skeletal-muscle Ca2+-release channel RyR1 (ryanodine receptor 1) were characterized...