Xiaoyu Pan

Functional Entry of Baculovirus into Insect and Mammalian Cells Is Dependent on Clathrin-Mediated Endocytosis

Long, Gang, Pan, Xiaoyu, Kormelink, Richard, Vlak, Just M.

Entry of the budded virus form of baculoviruses into insect and mammalian cells is generally thought to occur through a low-pH-dependent endocytosis pathway, possibly through clathrin-coated pits....

Functional Role of the Cytoplasmic Tail Domain of the Major Envelope Fusion Protein of Group II Baculoviruses

Long, Gang, Pan, Xiaoyu, Westenberg, Marcel, Vlak, Just M.

F proteins from baculovirus nucleopolyhedrovirus (NPV) group II members are the major budded virus (BV) viral envelope fusion proteins. They undergo furin-like proteolysis processing in order to be...

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Mao, Guogen, Pan, Xiaoyu, Zhu, Bei-Bei, Zhang, Yanbin, Yuan, Fenghua, Huang, Jian, ...

Patients with Alzheimer's disease (AD) exhibit higher levels of 8-oxo-guanine (8-oxoG) DNA lesions in their brain, suggesting a reduced or defective 8-oxoG repair. To test this hypothesis, this study...

Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors

Pan, Xiaoyu, Ou, Guangshuo, Civelekoglu-Scholey, Gul, Blacque, Oliver E., Endres, Nicholas F., Tao, Li, ...

The assembly and function of cilia on Caenorhabditis elegans neurons depends on the action of two kinesin-2 motors, heterotrimeric kinesin-II and homodimeric OSM-3–kinesin, which cooperate to move...

Conserved Leucines in N-Terminal Heptad Repeat HR1 of Envelope Fusion Protein F of Group II Nucleopolyhedroviruses Are Important for Correct Processing and Essential for Fusogenicity▿

Long, Gang, Pan, Xiaoyu, Vlak, Just M.

The heptad repeat (HR), a conserved structural motif of class I viral fusion proteins, is responsible for the formation of a six-helix bundle structure during the envelope fusion process. The insect...