Wolfgang Wienhold

Specific treatment of autoimmunity with recombinant invariant chains in which CLIP is replaced by self-epitopes

Bischof, Felix, Wienhold, Wolfgang, Wirblich, Christoph, Malcherek, Georg, Zevering, Olayinka, Kruisbeek, Ada M., ...

The invariant chain (Ii) binds to newly synthesized MHC class II molecules with the CLIP region of Ii occupying the peptide-binding groove. Here we demonstrate that recombinant Ii proteins with the...

Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis

Tolosa, Eva, Li, Weijie, Yasuda, Yoshiyuki, Wienhold, Wolfgang, Denzin, Lisa K., Lautwein, Alfred, ...

Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have...

Specific treatment of autoimmunity with recombinant invariant chains in which CLIP is replaced by self-epitopes

Bischof, Felix, Wienhold, Wolfgang, Wirblich, Christoph, Malcherek, Georg, Zevering, Olayinka, Kruisbeek, Ada M., ...

The invariant chain (Ii) binds to newly synthesized MHC class II molecules with the CLIP region of Ii occupying the peptide-binding groove. Here we demonstrate that recombinant Ii proteins with the...

Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis

Tolosa, Eva, Li, Weijie, Yasuda, Yoshiyuki, Wienhold, Wolfgang, Denzin, Lisa K., Lautwein, Alfred, ...

Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have...