Wolfgang Schmahl

Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L

Stypmann, Jörg, Gläser, Kerstin, Roth, Wera, Tobin, Desmond J., Petermann, Ivonne, Matthias, Rainer, ...

Dilated cardiomyopathy is a frequent cause of heart failure and is associated with high mortality. Progressive remodeling of the myocardium leads to increased dimensions of heart chambers. The role...

Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

Conrad, Marcus, Jakupoglu, Cemile, Moreno, Stéphanie G., Lippl, Stefanie, Banjac, Ana, Schneider, Manuela, ...

Oxygen radicals regulate many physiological processes, such as signaling, proliferation, and apoptosis, and thus play a pivotal role in pathophysiology and disease development. There are at least two...

Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L

Stypmann, Jörg, Gläser, Kerstin, Roth, Wera, Tobin, Desmond J., Petermann, Ivonne, Matthias, Rainer, ...

Dilated cardiomyopathy is a frequent cause of heart failure and is associated with high mortality. Progressive remodeling of the myocardium leads to increased dimensions of heart chambers. The role...

Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

Conrad, Marcus, Jakupoglu, Cemile, Moreno, Stéphanie G., Lippl, Stefanie, Banjac, Ana, Schneider, Manuela, ...

Oxygen radicals regulate many physiological processes, such as signaling, proliferation, and apoptosis, and thus play a pivotal role in pathophysiology and disease development. There are at least two...

Type IV Procollagen Missense Mutations Associated With Defects of the Eye, Vascular Stability, the Brain, Kidney Function and Embryonic or Postnatal Viability in the Mouse, Mus musculus: An Extension of the Col4a1 Allelic Series and the Identification of the First Two Col4a2 Mutant Alleles

Favor, Jack, Gloeckner, Christian Johannes, Janik, Dirk, Klempt, Martina, Neuhäuser-Klaus, Angelika, Pretsch, Walter, ...

The basement membrane is important for proper tissue development, stability, and physiology. Major components of the basement membrane include laminins and type IV collagens. The type IV procollagens...

The Role of Thioredoxin Reductases in Brain Development

Soerensen, Jonna, Jakupoglu, Cemile, Beck, Heike, Förster, Heidi, Schmidt, Jörg, Schmahl, Wolfgang, ...

The thioredoxin-dependent system is an essential regulator of cellular redox balance. Since oxidative stress has been linked with neurodegenerative disease, we studied the roles of thioredoxin...