Wolfgang Sadee

Genotyping panel for assessing response to cancer chemotherapy (2008)

Dai, Zunyan, Papp, Audrey C, Wang, Danxin, Hampel, Heather, Sadee, Wolfgang

Abstract Background Variants in numerous genes are thought to affect the success or failure of cancer chemotherapy. Interindividual variability can result from genes involved in drug metabolism and...

Strategies and Methods for Research on Sex Differences in Brain and Behavior (2005)

Becker, Jill B., Arnold, Arthur P., Berkley, Karen J., Blaustein, Jeffrey D., Eckel, Lisa, Hampson, Elizabeth, ...

Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although...

Evidence for Overlapping Substrate Specificity Between Large Neutral Amino Acid (LNAA) and Dipeptide (hPEPTl) Transporters for PD 158473, an NMDA Antagonist (1999)

Williamson, Rufus M., Amidon, Gordon L., Stewart, Barbra H., Surendran, Narayanan, Oh, Doo-Man, Sadee, Wolfgang, ...

Purpose . The objective of this research was to investigate the substrate specificity of large neutral amino acid carrier (LNAA) and di/tripeptide (hPEPTl) transporters with respect to PD 158473, an...

5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT Are Absorbed by the Intestinal PEPT1 Peptide Transporter (1998)

Oh, Doo-Man, Rhie, Julie K., Smith, Philip L., Lee, Chao-Pin, Sadee, Wolfgang, ...

Purpose . General use of nucleoside analogues in the treatment of viral infections and cancer is often limited by poor oral absorption. Valacyclovir, a water soluble amino acid ester prodrug of...

Intra- and Interindividual Variabilities of Valacyclovir Oral Bioavailability and Effect of Coadministration of an hPEPT1 Inhibitor

Phan, Dana D., Chin-Hong, Peter, Lin, Emil T., Anderle, Pascale, Sadee, Wolfgang, Guglielmo, B. Joseph

Variability in valacyclovir bioavailability and the potential for cephalexin-valacyclovir interaction were evaluated. The intraindividual acyclovir area under the concentration-time curve (AUC)...

Intra- and Interindividual Variabilities of Valacyclovir Oral Bioavailability and Effect of Coadministration of an hPEPT1 Inhibitor

Phan, Dana D., Chin-Hong, Peter, Lin, Emil T., Anderle, Pascale, Sadee, Wolfgang, Guglielmo, B. Joseph

Variability in valacyclovir bioavailability and the potential for cephalexin-valacyclovir interaction were evaluated. The intraindividual acyclovir area under the concentration-time curve (AUC)...