Groszer, Matthias, Keays, David A., Deacon, Robert M.J., De Bono, Joseph P., Prasad-Mulcare, Shweta, Gaub, Simone, ...
Prüfer, Kay, Muetzel, Bjoern, Do, Hong-Hai, Weiss, Gunter, Khaitovich, Philipp, Rahm, Erhard, ...
Abstract Background Genome-wide expression, sequence and association studies typically yield large sets of gene candidates, which must then be further analysed and interpreted. Information about...
The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals (2007)
Krause, Johannes, Lalueza-Fox, Carles, Ludovic, Orlando, Enard, Wolfgang, Green, Richard E., Burbano, Hernán A., ...
Evolution of primate gene expression (2006)
Khaitovich, Philipp, Enard, Wolfgang, Lachmann, Michael, Pääbo, Svante
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells (2006)
Fish, Jennifer L, Kosodo, Yoichi, Enard, Wolfgang, Paabo, Svante, Huttner, Wieland B
The ASPM (abnormal spindle-like microcephaly-associated) protein has previously been implicated in the determination of human cerebral cortical size, but the cell biological basis of this regulation...
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells (2006)
Fish, Jennifer L., Kosodo, Yoichi, Enard, Wolfgang, Pääbo, Svante, Huttner, Wieland B.
Positive selection on gene expression in the human brain (2006)
Khaitovich, Philipp, Tang, Kun, Franz, Henriette, Kelso, Janet, Hellmann, Ines, Enard, Wolfgang, ...
Functional analysis of human and chimpanzee promoters (2005)
Heissig, Florian, Krause, Johannes, Bryk, Jaroslaw, Khaitovich, Philipp, Enard, Wolfgang, Pääbo, Svante
Abstract Background It has long been argued that changes in gene expression may provide an additional and crucial perspective on the evolutionary differences between humans and chimpanzees. To...
Functional analysis of human and chimpanzee promoters (2005)
Heissig, Florian, Krause, Johannes, Bryk, Jaroslaw, Khaitovich, Philipp, Enard, Wolfgang, Pääbo, Svante
Primary microcephaly: a centrosomal disease? (2005)
Cox, J., Stern, R., Springell, K., Lindsay, S., Scott, S., Bond, J., ...
Initial sequence of the chimpanzee genome and comparison with the human genome (2005)
Mikkelsen, Tarjei S., Hillier, LaDeana W., Eichler, Evan E., Zody, Michael C., Jaffe, David B., Yang, Shiaw-Pyng, ...
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences...
Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees (2005)
Khaitovich, Philipp, Hellmann, Ines, Enard, Wolfgang, Nowick, Katja, Leinweber, M., Franz, H., ...
A Neutral Model of Transcriptome Evolution (2004)
Philipp Khaitovich, Gunter Weiss, Michael Lachmann, Ines Hellmann, Wolfgang Enard, Bjoern Muetzel, ...
Analysis of differences in gene expression between primate species suggests that the majority of them are selectively neutral and likely to have little or no functional consequences.
A Neutral Model of Transcriptome Evolution (2004)
Philipp Khaitovich, Gunter Weiss, Michael Lachmann, Ines Hellmann, Wolfgang Enard, Bjoern Muetzel, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
Differences in DNA methylation patterns between humans and chimpanzees (2004)
Enard, Wolfgang, Fassbender, Anne, Model, Fabian, Adorján, Péter, Pääbo, Svante, Olek, Alexander
Regional Patterns of Gene Expression in Human and Chimpanzee Brains (2004)
Khaitovich, Philipp, Muetzel, Bjoern, She, Xinwei, Lachmann, Michael, Hellmann, Ines, Dietzsch, Janko, ...
A Neutral Model of Transcriptome Evolution (2004)
Khaitovich, Phillip, Weiss, Gunter, Lachmann, Michael, Hellmann, Ines, Enard, Wolfgang, Muetzel, Bjoern, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
Regional patterns of gene expression in human and chimpanzee brains. (2004)
Khaitovich, Philipp, Muetzel, Bjoern, She, Xinwei, Lachmann, Michael, Hellmann, Ines, Dietzsch, Janko, ...
We have analyzed gene expression in various brain regions of humans and chimpanzees. Within both human and chimpanzee individuals, the transcriptomes of the cerebral cortex are very similar to each...
Selection on human genes as revealed by comparisons to chimpanzee cDNA (2003)
Hellmann, Ines, Zöllner, Sebastian, Enard, Wolfgang, Ebersberger, Ingo, Nickel, Birgit, Pääbo, Svante
Molecular evolution of FOXP2, a gene involved in speech and language (2002)
Enard, Wolfgang, Przeworski, Molly, Fisher, S. E., Lai, C. S. L., Wiebe, Victor, Kitano, T., ...
Language is a uniquely human trait likely to have been a prerequisite for the development of human culture. The ability to develop articulate speech relies on capabilities, such as fine control of...
Intra- and interspecific variation in primate gene expression patterns (2002)
Enard, Wolfgang, Khaitovich, Phillip, Klose, Joachim, Zöllner, Sebastian, Heissig, Florian, Giavalisco, P., ...
Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects....
Functional genomics in the chimpanzee (2002)
Enard, Wolfgang, Ebersberger, Ingo, Fischer, Anne, Heissig, Florian, Hellmann, Ines, Höffner, Barbara, ...
A split motor domain in a cytoplasmic dynein (2001)
Straube, A., Enard, Wolfgang, Berner, A., Wedlich-Soeldner, R., Kahmann, R., Steinberg, G.
A split motor domain in a cytoplasmic dynein. (2001)
Straube, A., Enard, Wolfgang, Berner, A., Wedlich-Söldner, R., Kahmann, R., Steinberg, G.
A split motor domain in a cytoplasmic dynein
Straube, Anne, Enard, Wolfgang, Berner, Alexandra, Wedlich-Söldner, Roland, Kahmann, Regine, Steinberg, Gero
The heavy chain of dynein forms a globular motor domain that tightly couples the ATP-cleavage region and the microtubule-binding site to transform chemical energy into motion along the cytoskeleton....
A Neutral Model of Transcriptome Evolution
Khaitovich, Philipp, Weiss, Gunter, Lachmann, Michael, Hellmann, Ines, Enard, Wolfgang, Muetzel, Bjoern, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
Selection on Human Genes as Revealed by Comparisons to Chimpanzee cDNA
Hellmann, Ines, Zöllner, Sebastian, Enard, Wolfgang, Ebersberger, Ingo, Nickel, Birgit, Pääbo, Svante
To better understand the evolutionary forces that affect human genes, we sequenced 5055 expressed sequence tags from the chimpanzee and compared them to their human counterparts. In conjunction with...
Regional Patterns of Gene Expression in Human and Chimpanzee Brains
Khaitovich, Philipp, Muetzel, Bjoern, She, Xinwei, Lachmann, Michael, Hellmann, Ines, Dietzsch, Janko, ...
We have analyzed gene expression in various brain regions of humans and chimpanzees. Within both human and chimpanzee individuals, the transcriptomes of the cerebral cortex are very similar to each...
Functional analysis of human and chimpanzee promoters
Heissig, Florian, Krause, Johannes, Bryk, Jaroslaw, Khaitovich, Philipp, Enard, Wolfgang, Pääbo, Svante
Twelve promoters of genes differentially expressed between humans and chimpanzees were tested for expression activity in culture cells. Seven promoters showed a significant difference in expression...
A split motor domain in a cytoplasmic dynein
Straube, Anne, Enard, Wolfgang, Berner, Alexandra, Wedlich-Söldner, Roland, Kahmann, Regine, Steinberg, Gero
The heavy chain of dynein forms a globular motor domain that tightly couples the ATP-cleavage region and the microtubule-binding site to transform chemical energy into motion along the cytoskeleton....
A Neutral Model of Transcriptome Evolution
Khaitovich, Philipp, Weiss, Gunter, Lachmann, Michael, Hellmann, Ines, Enard, Wolfgang, Muetzel, Bjoern, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
Selection on Human Genes as Revealed by Comparisons to Chimpanzee cDNA
Hellmann, Ines, Zöllner, Sebastian, Enard, Wolfgang, Ebersberger, Ingo, Nickel, Birgit, Pääbo, Svante
To better understand the evolutionary forces that affect human genes, we sequenced 5055 expressed sequence tags from the chimpanzee and compared them to their human counterparts. In conjunction with...
Regional Patterns of Gene Expression in Human and Chimpanzee Brains
Khaitovich, Philipp, Muetzel, Bjoern, She, Xinwei, Lachmann, Michael, Hellmann, Ines, Dietzsch, Janko, ...
We have analyzed gene expression in various brain regions of humans and chimpanzees. Within both human and chimpanzee individuals, the transcriptomes of the cerebral cortex are very similar to each...
Functional analysis of human and chimpanzee promoters
Heissig, Florian, Krause, Johannes, Bryk, Jaroslaw, Khaitovich, Philipp, Enard, Wolfgang, Pääbo, Svante
Twelve promoters of genes differentially expressed between humans and chimpanzees were tested for expression activity in culture cells. Seven promoters showed a significant difference in expression...
Woods, C. Geoffrey, Bond, Jacquelyn, Enard, Wolfgang
Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder. It is characterized by two principal features, microcephaly present at birth and nonprogressive mental retardation....
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
Fish, Jennifer L., Kosodo, Yoichi, Enard, Wolfgang, Pääbo, Svante, Huttner, Wieland B.
The ASPM (abnormal spindle-like microcephaly-associated) protein has previously been implicated in the determination of human cerebral cortical size, but the cell biological basis of this regulation...