Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
Andrechek, Eran R., Hardy, William R., Siegel, Peter M., Rudnicki, Michael A., Cardiff, Robert D., Muller, William J.
The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20–30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of...
ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival
Andrechek, Eran R., Hardy, William R., Girgis-Gabardo, Adele A., Perry, Robert L. S., Butler, Richard, Graham, Frank L., ...
Signaling mediated by ErbB2 is thought to play a critical role in numerous developmental processes. However, due to the embryonic lethality associated with the germ line inactivation of erbB2, its...
The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development
Chan, Richard, Hardy, William R., Laing, Michael A., Hardy, Sarah E., Muller, William J.
Activation of the epidermal growth factor receptor (EGFR) family is thought to play a critical role in both embryogenesis and oncogenesis. The diverse biological activities of the EGFR family are...
Andrechek, Eran R., Hardy, William R., Laing, Michael A., Muller, William J.
We have previously shown that mammary epithelial specific expression of the activated erbB2 allele under the control of the endogenous promoter in mice resulted in the formation of mammary...
Hilbert, Morton S., Beall, Joel C., Cary, William H., Dixon, William J., Dunsmore, Herbert J., Hardy, William R., ...
Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
Andrechek, Eran R., Hardy, William R., Siegel, Peter M., Rudnicki, Michael A., Cardiff, Robert D., Muller, William J.
The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20–30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of...
ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival
Andrechek, Eran R., Hardy, William R., Girgis-Gabardo, Adele A., Perry, Robert L. S., Butler, Richard, Graham, Frank L., ...
Signaling mediated by ErbB2 is thought to play a critical role in numerous developmental processes. However, due to the embryonic lethality associated with the germ line inactivation of erbB2, its...
The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development
Chan, Richard, Hardy, William R., Laing, Michael A., Hardy, Sarah E., Muller, William J.
Activation of the epidermal growth factor receptor (EGFR) family is thought to play a critical role in both embryogenesis and oncogenesis. The diverse biological activities of the EGFR family are...
Andrechek, Eran R., Hardy, William R., Laing, Michael A., Muller, William J.
We have previously shown that mammary epithelial specific expression of the activated erbB2 allele under the control of the endogenous promoter in mice resulted in the formation of mammary...