No abstract available.
Sanchez, Veronica, Greis, Kenneth D., Sztul, Elizabeth, Britt, William J.
The assembly of human cytomegalovirus (HCMV) is thought to be similar to that which has been proposed for alphaherpesviruses and involve envelopment of tegumented subviral particles at the nuclear...
Sanchez, Veronica, Sztul, Elizabeth, Britt, William J.
Although the assembly of herpesviruses has remained an active area of investigation, considerable controversy continues to surround the cellular location of tegument and envelope acquisition. This...
Jarvis, Michael A., Wang, C. Edward, Meyers, Heather L., Smith, Patricia P., Corless, Christopher L., Henderson, Gavin J., ...
Epithelial cells are known to be a major target for human cytomegalovirus (HCMV) infection; however, the analysis of virus-cell interactions has been difficult to approach due to the lack of in vitro...
Sequar, Getachew, Britt, William J., Lakeman, Fred D., Lockridge, Kristen M., Tarara, Ross P., Canfield, Don R., ...
Human cytomegalovirus (HCMV) possesses low pathogenic potential in an immunocompetent host. In the immunosuppressed host, however, a wide spectrum of infection outcomes, ranging from asymptomatic to...
The assembly of human cytomegalovirus (HCMV) with recombinant systems has not been accomplished. An understanding of specific interactions between individual capsid proteins could point to unique...
Britt, William J., Jarvis, Michael, Seo, Jun-Young, Drummond, Derek, Nelson, Jay
A highly efficient lambda phage recombination system previously utilized for studies of bacterial artificial chromosome (BAC)-maintained mouse chromosomal DNA was adapted for the study of the role of...
Jarvis, Michael A., Jones, Thomas R., Drummond, Derek D., Smith, Patsy P., Britt, William J., Nelson, Jay A., ...
Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified...
Wang, Zhongde, La Rosa, Corinna, Maas, Rebecca, Ly, Heang, Brewer, John, Mekhoubad, Shahram, ...
Human cytomegalovirus (CMV) is a viral pathogen that infects both genders, who remain asymptomatic unless they receive immunosuppressive drugs or acquire infections that cause reactivation of latent...
Netterwald, James R., Jones, Thomas R., Britt, William J., Yang, Shao-Jun, McCrone, Ian P., Zhu, Hua
Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results...
Three-Dimensional Localization of the Smallest Capsid Protein in the Human Cytomegalovirus Capsid
Yu, Xuekui, Shah, Sanket, Atanasov, Ivo, Lo, Pierrette, Liu, Fenyong, Britt, William J., ...
The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We...
Antigenic Domain 1 Is Required for Oligomerization of Human Cytomegalovirus Glycoprotein B
Britt, William J., Jarvis, Michael A., Drummond, Derek D., Mach, Michael
Human cytomegalovirus (HCMV) glycoprotein B (gB) is an abundant virion envelope protein that has been shown to be essential for the infectivity of HCMV. HCMV gB is also one of the most immunogenic...
Prichard, Mark N., Britt, William J., Daily, Shannon L., Hartline, Caroll B., Kern, Earl R.
Recombinant human cytomegaloviruses that do not express UL97 kinase activity exhibit a distinctive plaque morphology characterized by the formation of highly refractile bodies late in infection....
Shimamura, Masako, Mach, Michael, Britt, William J.
Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that infects 40 to 90% of adult human populations. HCMV infections are often asymptomatic in healthy individuals but can cause severe organ...
Seo, Jun-Young, Britt, William J.
The human cytomegalovirus UL99 open reading frame encodes a 190-amino-acid (aa) tegument protein, pp28, that is myristoylated and phosphorylated. pp28 is essential for assembly of infectious virus,...
Jarvis, Michael A., Borton, Jamie A., Keech, Amy M., Wong, John, Britt, William J., Magun, Bruce E., ...
Viral infection is associated with a vigorous inflammatory response characterized by cellular infiltration and release of the proinflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor...
Sanchez, Veronica, Greis, Kenneth D., Sztul, Elizabeth, Britt, William J.
The assembly of human cytomegalovirus (HCMV) is thought to be similar to that which has been proposed for alphaherpesviruses and involve envelopment of tegumented subviral particles at the nuclear...
Sanchez, Veronica, Sztul, Elizabeth, Britt, William J.
Although the assembly of herpesviruses has remained an active area of investigation, considerable controversy continues to surround the cellular location of tegument and envelope acquisition. This...
Jarvis, Michael A., Wang, C. Edward, Meyers, Heather L., Smith, Patricia P., Corless, Christopher L., Henderson, Gavin J., ...
Epithelial cells are known to be a major target for human cytomegalovirus (HCMV) infection; however, the analysis of virus-cell interactions has been difficult to approach due to the lack of in vitro...
Sequar, Getachew, Britt, William J., Lakeman, Fred D., Lockridge, Kristen M., Tarara, Ross P., Canfield, Don R., ...
Human cytomegalovirus (HCMV) possesses low pathogenic potential in an immunocompetent host. In the immunosuppressed host, however, a wide spectrum of infection outcomes, ranging from asymptomatic to...
The assembly of human cytomegalovirus (HCMV) with recombinant systems has not been accomplished. An understanding of specific interactions between individual capsid proteins could point to unique...
Britt, William J., Jarvis, Michael, Seo, Jun-Young, Drummond, Derek, Nelson, Jay
A highly efficient lambda phage recombination system previously utilized for studies of bacterial artificial chromosome (BAC)-maintained mouse chromosomal DNA was adapted for the study of the role of...
Jarvis, Michael A., Jones, Thomas R., Drummond, Derek D., Smith, Patsy P., Britt, William J., Nelson, Jay A., ...
Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified...
Wang, Zhongde, La Rosa, Corinna, Maas, Rebecca, Ly, Heang, Brewer, John, Mekhoubad, Shahram, ...
Human cytomegalovirus (CMV) is a viral pathogen that infects both genders, who remain asymptomatic unless they receive immunosuppressive drugs or acquire infections that cause reactivation of latent...
Netterwald, James R., Jones, Thomas R., Britt, William J., Yang, Shao-Jun, McCrone, Ian P., Zhu, Hua
Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results...
Three-Dimensional Localization of the Smallest Capsid Protein in the Human Cytomegalovirus Capsid
Yu, Xuekui, Shah, Sanket, Atanasov, Ivo, Lo, Pierrette, Liu, Fenyong, Britt, William J., ...
The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We...
Antigenic Domain 1 Is Required for Oligomerization of Human Cytomegalovirus Glycoprotein B
Britt, William J., Jarvis, Michael A., Drummond, Derek D., Mach, Michael
Human cytomegalovirus (HCMV) glycoprotein B (gB) is an abundant virion envelope protein that has been shown to be essential for the infectivity of HCMV. HCMV gB is also one of the most immunogenic...
Prichard, Mark N., Britt, William J., Daily, Shannon L., Hartline, Caroll B., Kern, Earl R.
Recombinant human cytomegaloviruses that do not express UL97 kinase activity exhibit a distinctive plaque morphology characterized by the formation of highly refractile bodies late in infection....
Shimamura, Masako, Mach, Michael, Britt, William J.
Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that infects 40 to 90% of adult human populations. HCMV infections are often asymptomatic in healthy individuals but can cause severe organ...
Seo, Jun-Young, Britt, William J.
The human cytomegalovirus UL99 open reading frame encodes a 190-amino-acid (aa) tegument protein, pp28, that is myristoylated and phosphorylated. pp28 is essential for assembly of infectious virus,...
Jarvis, Michael A., Borton, Jamie A., Keech, Amy M., Wong, John, Britt, William J., Magun, Bruce E., ...
Viral infection is associated with a vigorous inflammatory response characterized by cellular infiltration and release of the proinflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor...
Seo, Jun-Young, Britt, William J.
The assembly of herpesvirus remains incompletely defined due to the structural complexity of these viruses. Although the assembly of the capsid of these large DNA viruses is well studied and...
Krzyzaniak, Magdalena, Mach, Michael, Britt, William J.
The virion envelope of human cytomegalovirus (HCMV) is complex and consists of an incompletely defined number of glycoproteins. The gM/gN protein complex is the most abundant protein component of the...
Altered development of the brain after focal herpesvirus infection of the central nervous system
Koontz, Thad, Bralic, Marina, Tomac, Jelena, Pernjak-Pugel, Ester, Bantug, Glen, Jonjic, Stipan, ...
Human cytomegalovirus infection of the developing central nervous system (CNS) is a major cause of neurological damage in newborn infants and children. To investigate the pathogenesis of this human...
Seo, Jun-Young, Britt, William J.
Human cytomegalovirus (HCMV) UL99-encoded pp28 is an essential tegument protein required for envelopment and production of infectious virus. Nonenveloped virions accumulate in the cytoplasm of cells...