Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. (2006)
Wagner, Eric J., Ospina, Jason K., Hu, Yue, Dundr, Miroslav, Matera, A. Gregory, Marzluff, William F.
Formation of the 3' end of replication-dependent histone mRNAs is most robust during S phase and is mediated by both the stem-loop binding protein (SLBP) and the U7 snRNP. We previously identified a...
Jacobs, Erica Y., Frey, Mark R., Wu, Wei, Ingledue, Thomas C., Gebuhr, Thomas C., Gao, Liming, ...
Coiled bodies (CBs) are nuclear organelles involved in the metabolism of small nuclear RNAs (snRNAs) and histone messages. Their structural morphology and molecular composition have been conserved...
The Stem-Loop Binding Protein (SLBP1) Is Present in Coiled Bodies of the Xenopus Germinal Vesicle
Abbott, Jennifer, Marzluff, William F., Gall, Joseph G.
The stem-loop binding protein (SLBP1) binds the 3′ stem-loop of histone pre-mRNA and is required for efficient processing of histone transcripts in the nucleus. We examined the localization of...
Jacobs, Erica Y., Frey, Mark R., Wu, Wei, Ingledue, Thomas C., Gebuhr, Thomas C., Gao, Liming, ...
Coiled bodies (CBs) are nuclear organelles involved in the metabolism of small nuclear RNAs (snRNAs) and histone messages. Their structural morphology and molecular composition have been conserved...
Wang, Zeng-Feng, Ingledue, Thomas C., Dominski, Zbigniew, Sanchez, Ricardo, Marzluff, William F.
Translationally inactive histone mRNA is stored in frog oocytes, and translation is activated at oocyte maturation. The replication-dependent histone mRNAs are not polyadenylated and end in a...
Dominski, Zbigniew, Zheng, Lian-Xing, Sanchez, Ricardo, Marzluff, William F.
The 3′ end of histone mRNA is formed by an endonucleolytic cleavage of the primary transcript after a conserved stem-loop sequence. The cleavage reaction requires at least two trans-acting factors:...
Whitfield, Michael L., Zheng, Lian-Xing, Baldwin, Amy, Ohta, Tomohiko, Hurt, Myra M., Marzluff, William F.
The expression of the replication-dependent histone mRNAs is tightly regulated during the cell cycle. As cells progress from G1 to S phase, histone mRNA levels increase 35-fold, and they decrease...
Dominski, Zbigniew, Erkmann, Judith A., Greenland, John A., Marzluff, William F.
Expression of replication-dependent histone genes at the posttranscriptional level is controlled by stem-loop binding protein (SLBP). One function of SLBP is to bind the stem-loop structure in the...
Lanzotti, David J., Kaygun, Handan, Yang, Xiao, Duronio, Robert J., Marzluff, William F.
In metazoans, the 3′ end of histone mRNA is not polyadenylated but instead ends with a stem-loop structure that is required for cell cycle-regulated expression. The sequence of the stem-loop in the...
Moore, Jennifer C., Sumerel, Jan L., Schnackenberg, Bradley J., Nichols, Jason A., Wikramanayake, Athula, Wessel, Gary M., ...
cdk4 mRNA and protein are constitutively expressed in sea urchin eggs and throughout embryonic development. In contrast, cyclin D mRNA is barely detectable in eggs and early embryos, when the cell...
Ling, Jun, Morley, Simon J., Pain, Virginia M., Marzluff, William F., Gallie, Daniel R.
Metazoan cell cycle-regulated histone mRNAs are unique cellular mRNAs in that they terminate in a highly conserved stem-loop structure instead of a poly(A) tail. Not only is the stem-loop structure...
Dominski, Zbigniew, Yang, Xiao-cui, Raska, Christy S., Santiago, Carlos, Borchers, Christoph H., Duronio, Robert J., ...
Synthetic pre-mRNAs containing the processing signals encoded by Drosophila melanogaster histone genes undergo efficient and faithful endonucleolytic cleavage in nuclear extracts prepared from...
Sànchez, Ricardo, Marzluff, William F.
Metazoan replication-dependent histone mRNAs end in a conserved stem-loop rather than in the poly(A) tail found on all other mRNAs. The 3′ end of histone mRNA binds a single class of proteins, the...
Zheng, Lianxing, Dominski, Zbigniew, Yang, Xiao-Cui, Elms, Phillip, Raska, Christy S., Borchers, Christoph H., ...
The replication-dependent histone mRNAs, the only eukaryotic mRNAs that do not have poly(A) tails, are present only in S-phase cells. Coordinate posttranscriptional regulation of histone mRNAs is...
Cloning and characterization of the Drosophila U7 small nuclear RNA
Dominski, Zbigniew, Yang, Xiao-cui, Purdy, Matthew, Marzluff, William F.
Base pairing between the 5′ end of U7 small nuclear RNA (snRNA) and the histone downstream element (HDE) in replication-dependent histone pre-mRNAs is the key event in 3′-end processing that...
Sánchez, Ricardo, Marzluff, William F.
Metazoan replication-dependent histone mRNAs end in a stem-loop sequence. The one known exception is the histone mRNA in amphibian oocytes, which has a short oligo(A) tail attached to the stem-loop...
Lanzotti, David J., Kupsco, Jeremy M., Yang, Xiao-Cui, Dominski, Zbigniew, Marzluff, William F., Duronio, Robert J.
Stem-loop binding protein (SLBP) is an essential component of the histone pre-mRNA processing machinery. SLBP protein expression was examined during Drosophila development by using transgenes...
Robertson, Anthony J., Howard, Jason T., Dominski, Zbigniew, Schnackenberg, Bradley J., Sumerel, Jan L., McCarthy, John J., ...
Following the completion of oogenesis and oocyte maturation, histone mRNAs are synthesized and stored in the sea urchin egg pronucleus. Histone mRNAs are the only mRNAs that are not polyadenylated...
SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP
Whitfield, Michael L., Kaygun, Handan, Erkmann, Judith A., Dominski, Zbigniew, Marzluff, William F.
The stem–loop binding protein (SLBP) binds the 3′ end of histone mRNA and is present both in nucleus, and in the cytoplasm on the polyribosomes. SLBP participates in the processing of the histone...
Dominski, Zbigniew, Yang, Xiao-cui, Purdy, Matthew, Wagner, Eric J., Marzluff, William F.
Formation of the mature 3′ ends of the vast majority of cellular mRNAs occurs through cleavage and polyadenylation and requires a cleavage and polyadenylation specificity factor (CPSF) containing,...
Nuclear Import of the Stem–Loop Binding Protein and Localization during the Cell Cycle
Erkmann, Judith A., Wagner, Eric J., Dong, Jian, Zhang, Yanping, Kutay, Ulrike, Marzluff, William F.
A key factor involved in the processing of histone pre-mRNAs in the nucleus and translation of mature histone mRNAs in the cytoplasm is the stem–loop binding protein (SLBP). In this work, we have...
Translation Termination Is Involved in Histone mRNA Degradation when DNA Replication Is Inhibited
Kaygun, Handan, Marzluff, William F.
The levels of replication-dependent histone mRNAs are coordinately regulated with DNA synthesis. A major regulatory step in histone mRNA metabolism is regulation of the half-life of histone mRNAs....
NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein.
DeJong, Eric S, Marzluff, William F, Nikonowicz, Edward P
The 3' end of replication-dependent histone mRNAs terminate in a conserved sequence containing a stem-loop. This 26-nt sequence is the binding site for a protein, stem-loop binding protein (SLBP),...
ERKMANN, JUDITH A., SÀNCHEZ, RICARDO, TREICHEL, NATHALIE, MARZLUFF, WILLIAM F., KUTAY, ULRIKE
Replication-dependent histone mRNAs are the only metazoan mRNAs that are not polyadenylated, ending instead in a conserved stem–loop sequence. Histone pre-mRNAs lack introns and are processed in...
Sullivan, Eileen, Santiago, Carlos, Parker, Emily D., Dominski, Zbigniew, Yang, Xiaocui, Lanzotti, David J., ...
Replication-associated histone genes encode the only metazoan mRNAs that lack polyA tails, ending instead in a conserved 26-nt sequence that forms a stem–loop. Most of the regulation of mammalian...
Dominski, Zbigniew, Erkmann, Judith A., Yang, Xiaocui, Sànchez, Ricardo, Marzluff, William F.
The stem–loop binding protein (SLBP) is the posttranscriptional regulator of histone mRNA in metazoan cells. SLBP binds histone pre-mRNAs and facilitates 3′-end processing by promoting stable...
Differences and similarities between Drosophila and mammalian 3′ end processing of histone pre-mRNAs
DOMINSKI, ZBIGNIEW, YANG, XIAO-CUI, PURDY, MATHEW, MARZLUFF, WILLIAM F.
We used nuclear extracts from Drosophila Kc cells to characterize 3′ end processing of Drosophila histone pre-mRNAs. Drosophila SLBP plays a critical role in recruiting the U7 snRNP to the pre-mRNA...
Borchers, Christoph H., Thapar, Roopa, Petrotchenko, Evgeniy V., Torres, Matthew P., Speir, J. Paul, Easterling, Michael, ...
The stem–loop-binding protein (SLBP) is involved in multiple aspects of histone mRNA metabolism. To characterize the modification status and sites of SLBP, we combined mass spectrometric bottom-up...
U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis
GODFREY, ASHLEY C., KUPSCO, JEREMY M., BURCH, BRANDON D., ZIMMERMAN, RYAN M., DOMINSKI, ZBIGNIEW, MARZLUFF, WILLIAM F., ...
Metazoan replication-dependent histone mRNAs are not polyadenylated, and instead terminate in a conserved stem–loop structure generated by an endonucleolytic cleavage involving the U7 snRNP, which...
Wang, Helen X., Weerasinghe, Ravisha R., Perdue, Tony D., Cakmakci, Nihal G., Taylor, J. Philip, Marzluff, William F., ...
Signal transduction involving heterotrimeric G proteins is universal among fungi, animals, and plants. In plants and fungi, the best understood function for the G protein complex is its modulation of...
The Stem-Loop Binding Protein (SLBP1) Is Present in Coiled Bodies of the Xenopus Germinal Vesicle
Abbott, Jennifer, Marzluff, William F., Gall, Joseph G.
The stem-loop binding protein (SLBP1) binds the 3′ stem-loop of histone pre-mRNA and is required for efficient processing of histone transcripts in the nucleus. We examined the localization of...
Jacobs, Erica Y., Frey, Mark R., Wu, Wei, Ingledue, Thomas C., Gebuhr, Thomas C., Gao, Liming, ...
Coiled bodies (CBs) are nuclear organelles involved in the metabolism of small nuclear RNAs (snRNAs) and histone messages. Their structural morphology and molecular composition have been conserved...
Wang, Zeng-Feng, Ingledue, Thomas C., Dominski, Zbigniew, Sanchez, Ricardo, Marzluff, William F.
Translationally inactive histone mRNA is stored in frog oocytes, and translation is activated at oocyte maturation. The replication-dependent histone mRNAs are not polyadenylated and end in a...
Dominski, Zbigniew, Zheng, Lian-Xing, Sanchez, Ricardo, Marzluff, William F.
The 3′ end of histone mRNA is formed by an endonucleolytic cleavage of the primary transcript after a conserved stem-loop sequence. The cleavage reaction requires at least two trans-acting factors:...
Whitfield, Michael L., Zheng, Lian-Xing, Baldwin, Amy, Ohta, Tomohiko, Hurt, Myra M., Marzluff, William F.
The expression of the replication-dependent histone mRNAs is tightly regulated during the cell cycle. As cells progress from G1 to S phase, histone mRNA levels increase 35-fold, and they decrease...
Dominski, Zbigniew, Erkmann, Judith A., Greenland, John A., Marzluff, William F.
Expression of replication-dependent histone genes at the posttranscriptional level is controlled by stem-loop binding protein (SLBP). One function of SLBP is to bind the stem-loop structure in the...
Lanzotti, David J., Kaygun, Handan, Yang, Xiao, Duronio, Robert J., Marzluff, William F.
In metazoans, the 3′ end of histone mRNA is not polyadenylated but instead ends with a stem-loop structure that is required for cell cycle-regulated expression. The sequence of the stem-loop in the...
Moore, Jennifer C., Sumerel, Jan L., Schnackenberg, Bradley J., Nichols, Jason A., Wikramanayake, Athula, Wessel, Gary M., ...
cdk4 mRNA and protein are constitutively expressed in sea urchin eggs and throughout embryonic development. In contrast, cyclin D mRNA is barely detectable in eggs and early embryos, when the cell...
Ling, Jun, Morley, Simon J., Pain, Virginia M., Marzluff, William F., Gallie, Daniel R.
Metazoan cell cycle-regulated histone mRNAs are unique cellular mRNAs in that they terminate in a highly conserved stem-loop structure instead of a poly(A) tail. Not only is the stem-loop structure...
Dominski, Zbigniew, Yang, Xiao-cui, Raska, Christy S., Santiago, Carlos, Borchers, Christoph H., Duronio, Robert J., ...
Synthetic pre-mRNAs containing the processing signals encoded by Drosophila melanogaster histone genes undergo efficient and faithful endonucleolytic cleavage in nuclear extracts prepared from...
Sànchez, Ricardo, Marzluff, William F.
Metazoan replication-dependent histone mRNAs end in a conserved stem-loop rather than in the poly(A) tail found on all other mRNAs. The 3′ end of histone mRNA binds a single class of proteins, the...
Zheng, Lianxing, Dominski, Zbigniew, Yang, Xiao-Cui, Elms, Phillip, Raska, Christy S., Borchers, Christoph H., ...
The replication-dependent histone mRNAs, the only eukaryotic mRNAs that do not have poly(A) tails, are present only in S-phase cells. Coordinate posttranscriptional regulation of histone mRNAs is...
Dominski, Zbigniew, Erkmann, Judith A., Yang, Xiaocui, Sànchez, Ricardo, Marzluff, William F.
The stem–loop binding protein (SLBP) is the posttranscriptional regulator of histone mRNA in metazoan cells. SLBP binds histone pre-mRNAs and facilitates 3′-end processing by promoting stable...
Cloning and characterization of the Drosophila U7 small nuclear RNA
Dominski, Zbigniew, Yang, Xiao-cui, Purdy, Matthew, Marzluff, William F.
Base pairing between the 5′ end of U7 small nuclear RNA (snRNA) and the histone downstream element (HDE) in replication-dependent histone pre-mRNAs is the key event in 3′-end processing that...
Sullivan, Eileen, Santiago, Carlos, Parker, Emily D., Dominski, Zbigniew, Yang, Xiaocui, Lanzotti, David J., ...
Replication-associated histone genes encode the only metazoan mRNAs that lack polyA tails, ending instead in a conserved 26-nt sequence that forms a stem–loop. Most of the regulation of mammalian...
Sánchez, Ricardo, Marzluff, William F.
Metazoan replication-dependent histone mRNAs end in a stem-loop sequence. The one known exception is the histone mRNA in amphibian oocytes, which has a short oligo(A) tail attached to the stem-loop...
Lanzotti, David J., Kupsco, Jeremy M., Yang, Xiao-Cui, Dominski, Zbigniew, Marzluff, William F., Duronio, Robert J.
Stem-loop binding protein (SLBP) is an essential component of the histone pre-mRNA processing machinery. SLBP protein expression was examined during Drosophila development by using transgenes...
Robertson, Anthony J., Howard, Jason T., Dominski, Zbigniew, Schnackenberg, Bradley J., Sumerel, Jan L., McCarthy, John J., ...
Following the completion of oogenesis and oocyte maturation, histone mRNAs are synthesized and stored in the sea urchin egg pronucleus. Histone mRNAs are the only mRNAs that are not polyadenylated...
SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP
Whitfield, Michael L., Kaygun, Handan, Erkmann, Judith A., Dominski, Zbigniew, Marzluff, William F.
The stem–loop binding protein (SLBP) binds the 3′ end of histone mRNA and is present both in nucleus, and in the cytoplasm on the polyribosomes. SLBP participates in the processing of the histone...
Dominski, Zbigniew, Yang, Xiao-cui, Purdy, Matthew, Wagner, Eric J., Marzluff, William F.
Formation of the mature 3′ ends of the vast majority of cellular mRNAs occurs through cleavage and polyadenylation and requires a cleavage and polyadenylation specificity factor (CPSF) containing,...
Nuclear Import of the Stem–Loop Binding Protein and Localization during the Cell Cycle
Erkmann, Judith A., Wagner, Eric J., Dong, Jian, Zhang, Yanping, Kutay, Ulrike, Marzluff, William F.
A key factor involved in the processing of histone pre-mRNAs in the nucleus and translation of mature histone mRNAs in the cytoplasm is the stem–loop binding protein (SLBP). In this work, we have...
Translation Termination Is Involved in Histone mRNA Degradation when DNA Replication Is Inhibited
Kaygun, Handan, Marzluff, William F.
The levels of replication-dependent histone mRNAs are coordinately regulated with DNA synthesis. A major regulatory step in histone mRNA metabolism is regulation of the half-life of histone mRNAs....
NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein.
DeJong, Eric S, Marzluff, William F, Nikonowicz, Edward P
The 3' end of replication-dependent histone mRNAs terminate in a conserved sequence containing a stem-loop. This 26-nt sequence is the binding site for a protein, stem-loop binding protein (SLBP),...
ERKMANN, JUDITH A., SÀNCHEZ, RICARDO, TREICHEL, NATHALIE, MARZLUFF, WILLIAM F., KUTAY, ULRIKE
Replication-dependent histone mRNAs are the only metazoan mRNAs that are not polyadenylated, ending instead in a conserved stem–loop sequence. Histone pre-mRNAs lack introns and are processed in...
Differences and similarities between Drosophila and mammalian 3′ end processing of histone pre-mRNAs
DOMINSKI, ZBIGNIEW, YANG, XIAO-CUI, PURDY, MATHEW, MARZLUFF, WILLIAM F.
We used nuclear extracts from Drosophila Kc cells to characterize 3′ end processing of Drosophila histone pre-mRNAs. Drosophila SLBP plays a critical role in recruiting the U7 snRNP to the pre-mRNA...
U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis
GODFREY, ASHLEY C., KUPSCO, JEREMY M., BURCH, BRANDON D., ZIMMERMAN, RYAN M., DOMINSKI, ZBIGNIEW, MARZLUFF, WILLIAM F., ...
Metazoan replication-dependent histone mRNAs are not polyadenylated, and instead terminate in a conserved stem–loop structure generated by an endonucleolytic cleavage involving the U7 snRNP, which...
Borchers, Christoph H., Thapar, Roopa, Petrotchenko, Evgeniy V., Torres, Matthew P., Speir, J. Paul, Easterling, Michael, ...
The stem–loop-binding protein (SLBP) is involved in multiple aspects of histone mRNA metabolism. To characterize the modification status and sites of SLBP, we combined mass spectrometric bottom-up...
Wang, Helen X., Weerasinghe, Ravisha R., Perdue, Tony D., Cakmakci, Nihal G., Taylor, J. Philip, Marzluff, William F., ...
Signal transduction involving heterotrimeric G proteins is universal among fungi, animals, and plants. In plants and fungi, the best understood function for the G protein complex is its modulation of...
Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein
Wagner, Eric J., Ospina, Jason K., Hu, Yue, Dundr, Miroslav, Matera, A. Gregory, Marzluff, William F.
Formation of the 3′ end of replication-dependent histone mRNAs is most robust during S phase and is mediated by both the stem–loop binding protein (SLBP) and the U7 snRNP. We previously...
Wagner, Eric J., Marzluff, William F.
Metazoan replication-dependent histone mRNAs are the only eukaryotic mRNAs that are not polyadenylated. The cleavage of histone pre-mRNA to form the unique 3′ end requires the U7 snRNP and the...
Genome-wide analysis of mRNAs bound to the histone stem–loop binding protein
Pendergrass, Sarah A., Marzluff, William F., Whitfield, Michael L.
The replication-dependent histone mRNAs are cell-cycle-regulated and expressed only during S phase. In contrast to all other eukaryotic mRNAs, the histone mRNAs end in a highly conserved...
Kupsco, Jeremy M., Wu, Ming-Jing, Marzluff, William F., Thapar, Roopa, Duronio, Robert J.
The DnaQ-H family exonuclease Snipper (Snp) is a 33-kDa Drosophila melanogaster homolog of 3′hExo and ERI-1, exoribonucleases implicated in the degradation of histone mRNA in mammals and in the...