Novak, David J, Chen, Long, Ghadirian, Parviz, Hamel, Nancy, Zhang, Phil, Rossiny, Vanessa, ...
Abstract Background BRCA1 and BRCA2 account for the majority of the known familial breast cancer risk, however, the impact of other cancer susceptibility genes largely remains to be elucidated....
Foulkes, William D, Ghadirian, Parviz, Akbari, Mohammed, Hamel, Nancy, Giroux, Sylvie, Sabbaghian, Nelly, ...
Abstract Background PALB2 has recently been identified as a breast cancer susceptibility gene. PALB2 mutations are rare causes of hereditary breast cancer but may be important in countries such as...
Are triple-negative tumours and basal-like breast cancer synonymous? (2007)
Rakha, Emad A, Tan, David SP, Foulkes, William D, Ellis, Ian O, Tutt, Andrew, Nielsen, Torsten O, ...
No abstract available.
Use of immunohistochemical markers can refine prognosis in triple negative breast cancer (2007)
Tischkowitz, Marc, Brunet, Jean-Sébastien, Bégin, Louis R, Huntsman, David G, Cheang, Maggie CU, Akslen, Lars A, ...
Abstract Background Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the...
Use of immunohistochemical markers can refine prognosis in triple negative breast cancer (2007)
Tischkowitz, Marc, Brunet, Jean-Sébastien, Bégin, Louis R., Huntsman, David G., Cheang, Maggie C. U., Akslen, Lars A., ...
Background: Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the basis of...
Friedman, Eitan, Kotsopoulos, Joanne, Lubinski, Jan, Lynch, Henry T, Ghadirian, Parviz, Neuhausen, Susan L, ...
Abstract Introduction BRCA1 and BRCA2 mutation carriers are at increased risk for developing both breast and ovarian cancer. It has been suggested that carriers of BRCA1/2 mutations may also be at...
Oros, Kathleen K, Leblanc, Guy, Arcand, Suzanna L, Shen, Zhen, Perret, Chantal, Mes-Masson, Anne-Marie, ...
Abstract Background The 3398delAAAAG mutation in BRCA2 was recently found to recur in breast and/or ovarian cancer families from the French Canadian population of Quebec, a population that has...
Rudkin, Teresa M, Hamel, Nancy, Galvez, Maria, Hogervorst, Frans, Gille, Johan JP, Møller, Pål, ...
Abstract Background Analysis of the chromosomal background upon which a mutation occurs can be used to reconstruct the origins of specific disease-causing mutations. The relatively common BRCA1...
Changes in body weight and the risk of breast cancer in BRCA1and BRCA2mutation carriers (2005)
Kotsopoulos, Joanne, Olopade, Olufunmilayo I, Ghadirian, Parviz, Lubinski, Jan, Lynch, Henry T, Isaacs, Claudine, ...
Abstract Background Several anthropometric measures have been found to be associated with the risk of breast cancer. Current weight, body mass index, and adult weight gain appear to be predictors of...
Kasprzak, Lidia, Mesurolle, Benoit, Tremblay, Francine, Galvez, Maria, Halwani, Fawaz, Foulkes, William D
Abstract Background Primary prevention of breast cancer through prophylactic mastectomy can reduce the risk of malignancy in high-risk individuals. No type of mastectomy completely removes all breast...
Robson, Mark E, Chappuis, Pierre O, Satagopan, Jaya, Wong, Nora, Boyd, Jeff, Goffin, John R, ...
Abstract Background The prognostic significance of germline mutations in BRCA1 and BRCA2 in women with breast cancer remains unclear. A combined analysis was performed to address this uncertainty....
Hamel, Nancy, Kotar, Kimberley, Foulkes, William D
Abstract Background Relatives of BRCA1 and BRCA2 mutation carriers have long been proposed by epidemiological studies to have an increased risk of developing prostate cancer. In the Ashkenazi Jewish...
The funded proposal has not yet been activated. We have obtained DOD-endorsed ethical approval at McGill University, but because we are waiting for ethical approval at the other 2 sites we cannot...
The funded proposal has not yet been activated at all sites. Approval was given to commence the research at the McGill University hospital site only. IRB approval was obtained from in Switzerland and...
Foulkes, William D., Alpert, L., Deschenes, J., Tremblay, G.
Background and Hypothesis: BRCA1/2 mutations confer a substantially elevated risk of breast cancer. It is not known whether breast tissue from BRCAl/2 mutation carriers is normal of not. We...
The funded proposal has not yet begun at all sites. We have yet to receive the SPA for the Chicoutimi site but we are confident that this will happen shortly as all the necessary documents have been...
Foulkes, William D., Alpert, Lesley, Quenneville, Louise, Tremblay, Gilles
After review of 140 files, a total of 90 prevalent cases of breast cancer were recruited from both clinical genetic services at the Montreal Hospital sites. A total of 36 cases were examined by three...
The funded proposal has not yet begun at all sites. We have yet to receive the SPA for the Chicoutimi site but we are confident that this will happen shortly as all the necessary documents have been...
Identifying Early Events in BRCA2-Related Breast Cancer Using Isogenic Cell Lines (1998)
Three paired primary cell lines derived from BRCA- mutation carrying women have been established. These lines are B28T, B28N (BRCA2 mutation), B22T and B22N and B23T and B23N (BRCA1 mutation) where T...
Kasprzak, Lidia, Mesurolle, Benoit, Tremblay, Francine, Galvez, Maria, Halwani, Fawaz, Foulkes, William D
Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Kotsopoulos, Joanne, Olopado, Olufunmilayo I, Ghadirian, Parviz, Lubinski, Jan, Lynch, Henry T, Isaacs, Claudine, ...
The Importance of a Family History of Breast Cancer in Predicting the Presence of a BRCA Mutation
Foulkes, William D., Brunet, Jean-Sébastien, Warner, Ellen, Goodwin, Pamela J., Meschino, Wendy, Narod, Steven A., ...
Oros, Kathleen K, Leblanc, Guy, Arcand, Suzanna L, Shen, Zhen, Perret, Chantal, Mes-Masson, Anne-Marie, ...
Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
Friedman, Eitan, Kotsopoulos, Joanne, Lubinski, Jan, Lynch, Henry T, Ghadirian, Parviz, Neuhausen, Susan L, ...
Kasprzak, Lidia, Mesurolle, Benoit, Tremblay, Francine, Galvez, Maria, Halwani, Fawaz, Foulkes, William D
Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Kotsopoulos, Joanne, Olopado, Olufunmilayo I, Ghadirian, Parviz, Lubinski, Jan, Lynch, Henry T, Isaacs, Claudine, ...
The Importance of a Family History of Breast Cancer in Predicting the Presence of a BRCA Mutation
Foulkes, William D., Brunet, Jean-Sébastien, Warner, Ellen, Goodwin, Pamela J., Meschino, Wendy, Narod, Steven A., ...
Oros, Kathleen K, Leblanc, Guy, Arcand, Suzanna L, Shen, Zhen, Perret, Chantal, Mes-Masson, Anne-Marie, ...
Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
Friedman, Eitan, Kotsopoulos, Joanne, Lubinski, Jan, Lynch, Henry T, Ghadirian, Parviz, Neuhausen, Susan L, ...
Use of immunohistochemical markers can refine prognosis in triple negative breast cancer
Tischkowitz, Marc, Brunet, Jean-Sébastien, Bégin, Louis R, Huntsman, David G, Cheang, Maggie CU, Akslen, Lars A, ...
Analysis of PALB2/FANCN-associated breast cancer families
Tischkowitz, Marc, Xia, Bing, Sabbaghian, Nelly, Reis-Filho, Jorge S., Hamel, Nancy, Li, Guilan, ...
No more than ≈30% of hereditary breast cancer has been accounted for by mutations in known genes. Most of these genes, such as BRCA1, BRCA2, TP53, CHEK2, ATM, and FANCJ/BRIP1, function in DNA...
Are triple-negative tumours and basal-like breast cancer synonymous?
Rakha, Emad A, Tan, David SP, Foulkes, William D, Ellis, Ian O, Tutt, Andrew, Nielsen, Torsten O, ...