Wilfried Rossoll

Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death

Jablonka, Sibylle, Holtmann, Bettina, Meister, Gunter, Bandilla, Michael, Rossoll, Wilfried, Fischer, Utz, ...

Neuronal degeneration in spinal muscular atrophy is caused by reduced expression of the survival motor neuron (SMN) protein. SMN and the tightly interacting Gemin2 form part of a macromolecular...

Essential role of Bag-1 in differentiation and survival of hematopoietic and neuronal cells

Götz, Rudolf, Wiese, Stefan, Takayama, Shinichi, Camarero, Guadalupe C., Rossoll, Wilfried, Schweizer, Ulrich, ...

By targeted gene disruption in mice, we show that Bag-1, a co-chaperone for Hsp70 which interacts with C-Raf, B-Raf, Akt, Bcl-2, steroid hormone receptors and other proteins, plays an essential role...

Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells

Ito, Yasuhiro, Wiese, Stefan, Funk, Natalja, Chittka, Alexandra, Rossoll, Wilfried, Bömmel, Heike, ...

Ciliary neurotrophic factor (Cntf) plays an essential role in postnatal maintenance of spinal motoneurons. Whereas the expression of this neurotrophic factor is low during embryonic development, it...

Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death

Jablonka, Sibylle, Holtmann, Bettina, Meister, Gunter, Bandilla, Michael, Rossoll, Wilfried, Fischer, Utz, ...

Neuronal degeneration in spinal muscular atrophy is caused by reduced expression of the survival motor neuron (SMN) protein. SMN and the tightly interacting Gemin2 form part of a macromolecular...

Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells

Ito, Yasuhiro, Wiese, Stefan, Funk, Natalja, Chittka, Alexandra, Rossoll, Wilfried, Bömmel, Heike, ...

Ciliary neurotrophic factor (Cntf) plays an essential role in postnatal maintenance of spinal motoneurons. Whereas the expression of this neurotrophic factor is low during embryonic development, it...

Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease

Bömmel, Heike, Xie, Gang, Rossoll, Wilfried, Wiese, Stefan, Jablonka, Sibylle, Boehm, Thomas, ...

Progressive motor neuronopathy (pmn) mutant mice have been widely used as a model for human motoneuron disease. Mice that are homozygous for the pmn gene defect appear healthy at birth but develop...

Smn, the spinal muscular atrophy–determining gene product, modulates axon growth and localization of β-actin mRNA in growth cones of motoneurons

Rossoll, Wilfried, Jablonka, Sibylle, Andreassi, Catia, Kröning, Ann-Kathrin, Karle, Kathrin, Monani, Umrao R., ...

Spinal muscular atrophy (SMA), a common autosomal recessive form of motoneuron disease in infants and young adults, is caused by mutations in the survival motoneuron 1 (SMN1) gene. The corresponding...