Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk (2000)
Ellmeier, Wilfried, Jung, Steffen, Sunshine, Mary Jean, Hatam, Farah, Xu, Yang, Baltimore, David, ...
The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib
Hantschel, Oliver, Rix, Uwe, Schmidt, Uwe, Bürckstümmer, Tilmann, Kneidinger, Michael, Schütze, Gregor, ...
Dasatinib is a small-molecule kinase inhibitor used for the treatment of imatinib-resistant chronic myelogenous leukemia (CML). We have analyzed the kinases targeted by dasatinib by using an unbiased...
Schmidt, Uwe, Van Den Akker, Emile, Amelsvoort, Martine Parren-van, Litos, Gabi, De Bruijn, Marella, Gutiérrez, Laura, ...
Schmidt, Uwe, Van Den Akker, Emile, Litos, Gabi, De Bruijn, Marella, Gutiérrez, Laura, ...
Regulation of survival, expansion, and differentiation of erythroid progenitors requires the well-controlled activity of signaling pathways induced by erythropoietin (Epo) and stem cell factor (SCF)....
Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk
Ellmeier, Wilfried, Jung, Steffen, Sunshine, Mary Jean, Hatam, Farah, Xu, Yang, Baltimore, David, ...
The cytoplasmic protein tyrosine kinase Tec has been proposed to have important functions in hematopoiesis and lymphocyte signal transduction. Here we show that Tec-deficient mice developed normally...
Keppler, Oliver T., Welte, Frank J., Ngo, Tuan A., Chin, Peggy S., Patton, Kathryn S., Tsou, Chia-Lin, ...
The development of a permissive small animal model for the study of human immunodeficiency virus type (HIV)-1 pathogenesis and the testing of antiviral strategies has been hampered by the inability...