Selection of RNA Aptamers to the Alzheimer's Disease Amyloid Peptide (2002)
Ylera,Francisco, Lurz,Rudi, Erdmann,Volker A., Fürste,Jens Peter
Alzheimer's disease is correlated with the deposition of amyloid peptides in the brain of the patients. The amyloid is thus a major target in the search for novel diagnostic and therapeutic...
Selection of RNA Aptamers to the Alzheimer's Disease Amyloid Peptide (2002)
Ylera, Francisco, Lurz, Rudi, Erdmann, Volker A., Fürste, Jens Peter
Alzheimer's disease is correlated with the deposition of amyloid peptides in the brain of the patients. The amyloid is thus a major target in the search for novel diagnostic and therapeutic...
Collection of mRNA-like non-coding RNAs (2001)
Volker A. Erdmann, Maciej Szymanski, Abraham Hochberg, Nathan De Groot
In last few years much data has accumulated which shows that in different cells various RNA transcripts are synthesized. They lack protein coding capacity and do not produce mature protein. It seems...
Maciej Szymanski, Thomas Specht, Miroslawa Z. Barciszewska, Jan Barciszewski, Volker A. Erdmann
In this paper we present the updated version of the compilation of 5S rRNA and 5S rDNA nucleotide sequences. It contains 1622 primary structures of 5S rRNAs and 5S rRNA genes from 888 species. These...
Braunschweig, T. U., Naturwiss. F., Diss. v. 12. Juni 1968.
The non-coding RNAs as riboregulators
Erdmann, Volker A., Barciszewska, Miroslawa Z., Szymanski, Maciej, Hochberg, Abraham, Groot, Nathan De, Barciszewski, Jan
The non-coding RNAs database (http://biobases.ibch.poznan.pl/ncRNA/) contains currently available data on RNAs, which do not have long open reading frames and act as riboregulators. Non-coding RNAs...
Szymanski, Maciej, Barciszewska, Miroslawa Z., Erdmann, Volker A., Barciszewski, Jan
Ribosomal 5S RNA (5S rRNA) is an integral component of the large ribosomal subunit in all known organisms with the exception only of mitochondrial ribosomes of fungi and animals. It is thought to...
Non-coding, mRNA-like RNAs database Y2K
Erdmann, Volker A., Szymanski, Maciej, Hochberg, Abraham, Groot, Nathan De, Barciszewski, Jan
In last few years much data has accumulated on various non-translatable RNA transcripts that are synthesised in different cells. They are lacking in protein coding capacity and it seems that they...
Szymanski, Maciej, Barciszewska, Miroslawa Z., Barciszewski, Jan, Erdmann, Volker A.
This paper presents the updated version (Y2K) of the database of ribosomal 5S ribonucleic acids (5S rRNA) and their genes (5S rDNA), http://rose.man/poznan. pl/5SData/index.html . This edition of the...
Design of antisense oligonucleotides stabilized by locked nucleic acids
Kurreck, Jens, Wyszko, Eliza, Gillen, Clemens, Erdmann, Volker A.
The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied DNA oligonucleotides, phosphorothioates and 2′-O-methyl gapmers. In...
Grünweller, Arnold, Wyszko, Eliza, Bieber, Birgit, Jahnel, Ricarda, Erdmann, Volker A., Kurreck, Jens
Locked nucleic acids (LNAs) and double-stranded small interfering RNAs (siRNAs) are rather new promising antisense molecules for cell culture and in vivo applications. Here, we compare...
Noncoding regulatory RNAs database
Szymański, Maciej, Erdmann, Volker A., Barciszewski, Jan
The noncoding RNAs database is a collection of currently available sequence data on RNAs, which have no protein-coding capacity and have been implicated in regulation of cellular processes. The RNAs...
RNA cleaving ‘10-23’ DNAzymes with enhanced stability and activity
Schubert, Steffen, Gül, Deniz C., Grunert, Hans-Peter, Zeichhardt, Heinz, Erdmann, Volker A., Kurreck, Jens
‘10-23’ DNAzymes can be used to cleave any target RNA in a sequence-specific manner. For applications in vivo, they have to be stabilised against nucleolytic attack by the introduction of...
Collection of published 5S and 5.8S ribosomal RNA sequences
Erdmann, Volker A., Wolters, Jörn, Huysmans, Erik, Vandenberghe, Antoon, De Wachter, Rupert
Collection of published 5S, 5.8S and 4.5S ribosomal RNA sequences
Erdmann, Volker A., Wolters, Jörn, Huysmans, Erik, De Wachter, Rupert
Collection of published 5S and 5.8S ribosomal RNA sequences
Erdmann, Volker A., Huysmans, Erik, Vandenberghe, Antoon, De Wachter, Rupert
Komiya, Hiroyuki, Kawakami, Makoto, Takemura, Shosuke, Kumagai, Izumi, Erdmann, Volker A.
The nucleotide sequence of 5S rRNA from an extreme thermophile Thermusthermophilus HB8 has been re-examined and determined as [Formula: see text] The present study could resolve previously ambiguous...
The nucleotide sequence of 5S rRNA from an extreme thermophile, Thermus thermophilus HB8
Kumagai, Izumi, Digweed, Martin, Erdmann, Volker A., Watanabe, Kimitsuna, Oshima, Tairo
Using 3′- and 5′-end labelling sequencing techniques, the following primary structure for Thermusthermophilus HB8 5S RNA could be determined: pAA (U)...
Compilation of 5S rRNA and 5S rRNA gene sequences
Specht, Thomas, Wolters, Jörn, Erdmann, Volker A.
This is an update for the 5S rRNA sequences of the BERLIN RNA DATABANK last published in 1990 (1). The new entry consists of 25 eubacterial and 2 eukaryotic 5S rRNA sequences and 10 plant 5S rRNA...
Compilation of 5S rRNA and 5S rRNA gene sequences
Specht, Thomas, Wolters, Jörn, Erdmann, Volker A.
The BERLIN RNA DATABANK as of Dezember 31, 1989, contains a total of 667 sequences of 5S rRNAs or their genes, which is an increase of 114 new sequence entries over the last compilation (1). It...
Richter, Dietmar, Erdmann, Volker A., Sprinzl, Mathias
The tetranucleotide TpΨpCpGp, when bound to Escherichia coli 50S ribosomal subunits, can replace intact tRNA in the stringent factor-directed synthesis of guanosine tetra- and pentaphosphates. The...
ATPase and GTPase Activities Associated with a Specific 5S RNA-Protein Complex*
Horne, Janet R., Erdmann, Volker A.
An RNA-protein complex consisting of 5S RNA and two ribosomal proteins, B-L5 and B-L22, was isolated from Bacillus stearothermophilus ribosomes and found to be active in GTP hydrolysis. This activity...
Pongs, Olaf, Bald, Rolf, Erdmann, Volker A.
Monoiodoamphenicol, a synthetic analogue of chloramphenicol, has been shown by competition experiments with chloramphenicol and lincomycin to bind at the same site of 70S ribosomes as...
Application of locked nucleic acids to improve aptamer in vivo stability and targeting function
Schmidt, Kathrin S., Borkowski, Sandra, Kurreck, Jens, Stephens, Andrew W., Bald, Rolf, Hecht, Maren, ...
Aptamers are powerful candidates for molecular imaging applications due to a number of attractive features, including rapid blood clearance and tumor penetration. We carried out structure–activity...
5 S rRNA: structure and interactions.
Szymański, Maciej, Barciszewska, Mirosława Z, Erdmann, Volker A, Barciszewski, Jan
5 S rRNA is an integral component of the large ribosomal subunit in all known organisms. Despite many years of intensive study, the function of 5 S rRNA in the ribosome remains unknown. Advances in...
The non-coding RNAs as riboregulators
Erdmann, Volker A., Barciszewska, Miroslawa Z., Szymanski, Maciej, Hochberg, Abraham, Groot, Nathan De, Barciszewski, Jan
The non-coding RNAs database (http://biobases.ibch.poznan.pl/ncRNA/) contains currently available data on RNAs, which do not have long open reading frames and act as riboregulators. Non-coding RNAs...
Szymanski, Maciej, Barciszewska, Miroslawa Z., Erdmann, Volker A., Barciszewski, Jan
Ribosomal 5S RNA (5S rRNA) is an integral component of the large ribosomal subunit in all known organisms with the exception only of mitochondrial ribosomes of fungi and animals. It is thought to...
Non-coding, mRNA-like RNAs database Y2K
Erdmann, Volker A., Szymanski, Maciej, Hochberg, Abraham, Groot, Nathan De, Barciszewski, Jan
In last few years much data has accumulated on various non-translatable RNA transcripts that are synthesised in different cells. They are lacking in protein coding capacity and it seems that they...
Szymanski, Maciej, Barciszewska, Miroslawa Z., Barciszewski, Jan, Erdmann, Volker A.
This paper presents the updated version (Y2K) of the database of ribosomal 5S ribonucleic acids (5S rRNA) and their genes (5S rDNA), http://rose.man/poznan. pl/5SData/index.html . This edition of the...
Design of antisense oligonucleotides stabilized by locked nucleic acids
Kurreck, Jens, Wyszko, Eliza, Gillen, Clemens, Erdmann, Volker A.
The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied DNA oligonucleotides, phosphorothioates and 2′-O-methyl gapmers. In...
Grünweller, Arnold, Wyszko, Eliza, Bieber, Birgit, Jahnel, Ricarda, Erdmann, Volker A., Kurreck, Jens
Locked nucleic acids (LNAs) and double-stranded small interfering RNAs (siRNAs) are rather new promising antisense molecules for cell culture and in vivo applications. Here, we compare...
Noncoding regulatory RNAs database
Szymański, Maciej, Erdmann, Volker A., Barciszewski, Jan
The noncoding RNAs database is a collection of currently available sequence data on RNAs, which have no protein-coding capacity and have been implicated in regulation of cellular processes. The RNAs...
RNA cleaving ‘10-23’ DNAzymes with enhanced stability and activity
Schubert, Steffen, Gül, Deniz C., Grunert, Hans-Peter, Zeichhardt, Heinz, Erdmann, Volker A., Kurreck, Jens
‘10-23’ DNAzymes can be used to cleave any target RNA in a sequence-specific manner. For applications in vivo, they have to be stabilised against nucleolytic attack by the introduction of...
Collection of published 5S and 5.8S ribosomal RNA sequences
Erdmann, Volker A., Wolters, Jörn, Huysmans, Erik, Vandenberghe, Antoon, De Wachter, Rupert
Collection of published 5S, 5.8S and 4.5S ribosomal RNA sequences
Erdmann, Volker A., Wolters, Jörn, Huysmans, Erik, De Wachter, Rupert
Collection of published 5S and 5.8S ribosomal RNA sequences
Erdmann, Volker A., Huysmans, Erik, Vandenberghe, Antoon, De Wachter, Rupert
Komiya, Hiroyuki, Kawakami, Makoto, Takemura, Shosuke, Kumagai, Izumi, Erdmann, Volker A.
The nucleotide sequence of 5S rRNA from an extreme thermophile Thermusthermophilus HB8 has been re-examined and determined as [Formula: see text] The present study could resolve previously ambiguous...
The nucleotide sequence of 5S rRNA from an extreme thermophile, Thermus thermophilus HB8
Kumagai, Izumi, Digweed, Martin, Erdmann, Volker A., Watanabe, Kimitsuna, Oshima, Tairo
Using 3′- and 5′-end labelling sequencing techniques, the following primary structure for Thermusthermophilus HB8 5S RNA could be determined: pAA (U)...
Compilation of 5S rRNA and 5S rRNA gene sequences
Specht, Thomas, Wolters, Jörn, Erdmann, Volker A.
This is an update for the 5S rRNA sequences of the BERLIN RNA DATABANK last published in 1990 (1). The new entry consists of 25 eubacterial and 2 eukaryotic 5S rRNA sequences and 10 plant 5S rRNA...
Compilation of 5S rRNA and 5S rRNA gene sequences
Specht, Thomas, Wolters, Jörn, Erdmann, Volker A.
The BERLIN RNA DATABANK as of Dezember 31, 1989, contains a total of 667 sequences of 5S rRNAs or their genes, which is an increase of 114 new sequence entries over the last compilation (1). It...
Richter, Dietmar, Erdmann, Volker A., Sprinzl, Mathias
The tetranucleotide TpΨpCpGp, when bound to Escherichia coli 50S ribosomal subunits, can replace intact tRNA in the stringent factor-directed synthesis of guanosine tetra- and pentaphosphates. The...
ATPase and GTPase Activities Associated with a Specific 5S RNA-Protein Complex*
Horne, Janet R., Erdmann, Volker A.
An RNA-protein complex consisting of 5S RNA and two ribosomal proteins, B-L5 and B-L22, was isolated from Bacillus stearothermophilus ribosomes and found to be active in GTP hydrolysis. This activity...
Pongs, Olaf, Bald, Rolf, Erdmann, Volker A.
Monoiodoamphenicol, a synthetic analogue of chloramphenicol, has been shown by competition experiments with chloramphenicol and lincomycin to bind at the same site of 70S ribosomes as...
Application of locked nucleic acids to improve aptamer in vivo stability and targeting function
Schmidt, Kathrin S., Borkowski, Sandra, Kurreck, Jens, Stephens, Andrew W., Bald, Rolf, Hecht, Maren, ...
Aptamers are powerful candidates for molecular imaging applications due to a number of attractive features, including rapid blood clearance and tumor penetration. We carried out structure–activity...
5 S rRNA: structure and interactions.
Szymański, Maciej, Barciszewska, Mirosława Z, Erdmann, Volker A, Barciszewski, Jan
5 S rRNA is an integral component of the large ribosomal subunit in all known organisms. Despite many years of intensive study, the function of 5 S rRNA in the ribosome remains unknown. Advances in...
Noncoding RNAs database (ncRNAdb)
Szymanski, Maciej, Erdmann, Volker A., Barciszewski, Jan
The noncoding RNA database (ncRNAdb) was created as a source of information on RNA molecules, which do not possess protein-coding capacity. It is now widely accepted that, in addition to...
Detection of Oncofetal H19 RNA in Rheumatoid Arthritis Synovial Tissue
Stuhlmüller, Bruno, Kunisch, Elke, Franz, Juliane, Martinez-Gamboa, Lorena, Hernandez, Maria M., Pruss, Axel, ...
The expression of oncofetal H19 RNA and its localization/cellular source was analyzed in synovial tissue (ST) and isolated synovial macrophages (Mφ) or synovial fibroblasts (SFBs) by reverse...
Crystallization and preliminary X-ray diffraction analysis of a tRNASer acceptor-stem microhelix
Förster, Charlotte, Krauss, Norbert, Brauer, Arnd B. E., Szkaradkiewicz, Karol, Brode, Svenja, Hennig, Klaus, ...
In order to investigate tRNA identity elements, an elongator tRNASer acceptor-stem helix was crystallized and a data set was collected to 1.8 Å resolution aiming at a comparison with the...
Förster, Charlotte, Brauer, Arnd B. E., Brode, Svenja, Schmidt, Kathrin S., Perbandt, Markus, Meyer, Arne, ...
Locked nucleic acid (LNA) nucleotides are RNA analogues with a useful additional conformational constraint; the current investigation will provide the first crystallographic view of an all-LNA duplex.