Victoria H. Cowling

A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G2 Arrest†

Cowling, Victoria H., Chandriani, Sanjay, Whitfield, Michael L., Cole, Michael D.

The myc family of oncogenes is well conserved throughout evolution. Here we present the characterization of a domain conserved in c-, N-, and L-Myc from fish to humans, N-Myc317-337, designated Myc...

A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G2 Arrest

Cowling, Victoria H., Chandriani, Sanjay, Whitfield, Michael L., Cole, Michael D.

A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G2 Arrest†

Cowling, Victoria H., Chandriani, Sanjay, Whitfield, Michael L., Cole, Michael D.

The myc family of oncogenes is well conserved throughout evolution. Here we present the characterization of a domain conserved in c-, N-, and L-Myc from fish to humans, N-Myc317-337, designated Myc...

A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G2 Arrest

Cowling, Victoria H., Chandriani, Sanjay, Whitfield, Michael L., Cole, Michael D.

The Myc Transactivation Domain Promotes Global Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain Independently of Direct DNA Binding▿ †

Cowling, Victoria H., Cole, Michael D.

Myc is a transcription factor which is dependent on its DNA binding domain for transcriptional regulation of target genes. Here, we report the surprising finding that Myc mutants devoid of direct DNA...

c-Myc Transforms Human Mammary Epithelial Cells through Repression of the Wnt Inhibitors DKK1 and SFRP1▿ †

Cowling, Victoria H., D'Cruz, Celina M., Chodosh, Lewis A., Cole, Michael D.

c-myc is frequently amplified in breast cancer; however, the mechanism of myc-induced mammary epithelial cell transformation has not been defined. We show that c-Myc induces a profound morphological...