Malek, Adel M., Ahlquist, Richard, Gibbons, Gary H., Dzau, Victor J., Izumo, Seigo
Living cells are constantly exposed to a variety of complex mechanical stimuli which are though to be critical in the control of tissue structure and function. Endothelial and smooth muscle cells in...
Hein, Lutz, Stevens, Mary E., Barsh, Gregory S., Pratt, Richard E., Kobilka, Brian K., Dzau, Victor J.
Previous studies have suggested that angiotensin II (Ang II) modulates cardiac contractility, rhythm, metabolism, and structure. However, it is unclear whether the cardiac effects are due to direct...
Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues
Mann, Michael J., Gibbons, Gary H., Hutchinson, Howard, Poston, Robert S., Hoyt, E. Grant, Robbins, Robert C., ...
The application of gene therapy to human disease is currently restricted by the relatively low efficiency and potential hazards of methods of oligonucleotide or gene delivery. Antisense or...
LXRα functions as a cAMP-responsive transcriptional regulator of gene expression
Tamura, Kouichi, Chen, Yuqing E., Horiuchi, Masatsugu, Chen, Qin, Daviet, Laurent, Yang, Zhiyong, ...
LXRα is a member of a nuclear receptor superfamily that regulates transcription. LXRα forms a heterodimer with RXRα, another member of this family, to regulate the expression of cholesterol...
Lopez-Ilasaca, Marco, Liu, Xiushi, Tamura, Koichi, Dzau, Victor J.
Our group identified angiotensin II type 1 (AT1) receptor-associated protein (ATRAP) in a yeast two-hybrid screen for proteins that bind to the carboxyl-terminal cytoplasmic domain of the AT1. In...
High-Throughput Genotyping with Single Nucleotide Polymorphisms
Ranade, Koustubh, Chang, Mau-Song, Ting, Chih-Tai, Pei, Dee, Hsiao, Chin-Fu, Olivier, Michael, ...
To make large-scale association studies a reality, automated high-throughput methods for genotyping with single-nucleotide polymorphisms (SNPs) are needed. We describe PCR conditions that permit the...
Akishita, Masahiro, Ito, Masaaki, Lehtonen, Jukka Y.A., Daviet, Laurent, Dzau, Victor J., Horiuchi, Masatsugu
Angiotensin II type 2 (AT2) receptor is abundantly expressed in vascular smooth muscle cells (VSMC) of the fetal vasculature during late gestation (embryonic day 15–20), during which the blood...
Braun-Dullaeus, Ruediger C., Mann, Michael J., Ziegler, Almut, Von Der Leyen, Heiko E., Dzau, Victor J.
Angiotensin II (Ang II) has been shown to stimulate either hypertrophy or hyperplasia. We postulated that the differential response of vascular smooth muscle cells (VSMCs) to Ang II is mediated by...
Pachori, Alok S., Melo, Luis G., Hart, Melanie L., Noiseux, Nicholas, Zhang, Lunan, Morello, Fulvio, ...
Ischemia and reperfusion represent major mechanisms of tissue injury and organ failure. The timing of administration and the duration of action limit current treatment approaches using...
Liver X receptors α and β regulate renin expression in vivo
Morello, Fulvio, De Boer, Rudolf A., Steffensen, Knut R., Gnecchi, Massimiliano, Chisholm, Jeffrey W., Boomsma, Frans, ...
The renin-angiotensin-aldosterone system controls blood pressure and salt-volume homeostasis. Renin, which is the first enzymatic step of the cascade, is critically regulated at the transcriptional...
Searching for transcriptional regulators of Ang II–induced vascular pathology
Dzau, Victor J., Lopez-Ilasaca, Marco
Ang II plays a key role in cardiovascular regulation and participates in vascular pathobiology, including inflammation and remodeling. Whether these tissue effects are mediated by direct Ang II...
Hein, Lutz, Stevens, Mary E., Barsh, Gregory S., Pratt, Richard E., Kobilka, Brian K., Dzau, Victor J.
Previous studies have suggested that angiotensin II (Ang II) modulates cardiac contractility, rhythm, metabolism, and structure. However, it is unclear whether the cardiac effects are due to direct...
Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues
Mann, Michael J., Gibbons, Gary H., Hutchinson, Howard, Poston, Robert S., Hoyt, E. Grant, Robbins, Robert C., ...
The application of gene therapy to human disease is currently restricted by the relatively low efficiency and potential hazards of methods of oligonucleotide or gene delivery. Antisense or...
LXRα functions as a cAMP-responsive transcriptional regulator of gene expression
Tamura, Kouichi, Chen, Yuqing E., Horiuchi, Masatsugu, Chen, Qin, Daviet, Laurent, Yang, Zhiyong, ...
LXRα is a member of a nuclear receptor superfamily that regulates transcription. LXRα forms a heterodimer with RXRα, another member of this family, to regulate the expression of cholesterol...
Lopez-Ilasaca, Marco, Liu, Xiushi, Tamura, Koichi, Dzau, Victor J.
Our group identified angiotensin II type 1 (AT1) receptor-associated protein (ATRAP) in a yeast two-hybrid screen for proteins that bind to the carboxyl-terminal cytoplasmic domain of the AT1. In...
High-Throughput Genotyping with Single Nucleotide Polymorphisms
Ranade, Koustubh, Chang, Mau-Song, Ting, Chih-Tai, Pei, Dee, Hsiao, Chin-Fu, Olivier, Michael, ...
To make large-scale association studies a reality, automated high-throughput methods for genotyping with single-nucleotide polymorphisms (SNPs) are needed. We describe PCR conditions that permit the...
Akishita, Masahiro, Ito, Masaaki, Lehtonen, Jukka Y.A., Daviet, Laurent, Dzau, Victor J., Horiuchi, Masatsugu
Angiotensin II type 2 (AT2) receptor is abundantly expressed in vascular smooth muscle cells (VSMC) of the fetal vasculature during late gestation (embryonic day 15–20), during which the blood...
Braun-Dullaeus, Ruediger C., Mann, Michael J., Ziegler, Almut, Von Der Leyen, Heiko E., Dzau, Victor J.
Angiotensin II (Ang II) has been shown to stimulate either hypertrophy or hyperplasia. We postulated that the differential response of vascular smooth muscle cells (VSMCs) to Ang II is mediated by...
Pachori, Alok S., Melo, Luis G., Hart, Melanie L., Noiseux, Nicholas, Zhang, Lunan, Morello, Fulvio, ...
Ischemia and reperfusion represent major mechanisms of tissue injury and organ failure. The timing of administration and the duration of action limit current treatment approaches using...
Liver X receptors α and β regulate renin expression in vivo
Morello, Fulvio, De Boer, Rudolf A., Steffensen, Knut R., Gnecchi, Massimiliano, Chisholm, Jeffrey W., Boomsma, Frans, ...
The renin-angiotensin-aldosterone system controls blood pressure and salt-volume homeostasis. Renin, which is the first enzymatic step of the cascade, is critically regulated at the transcriptional...
Searching for transcriptional regulators of Ang II–induced vascular pathology
Dzau, Victor J., Lopez-Ilasaca, Marco
Ang II plays a key role in cardiovascular regulation and participates in vascular pathobiology, including inflammation and remodeling. Whether these tissue effects are mediated by direct Ang II...
Cunha-Neto, Edecio, Dzau, Victor J., Allen, Paul D., Stamatiou, Dimitri, Benvenutti, Luiz, Higuchi, M. Lourdes, ...
Chronic Chagas’ disease cardiomyopathy is a leading cause of congestive heart failure in Latin America, affecting more than 3 million people. Chagas’ cardiomyopathy is more aggressive than other...
Barrans, J. David, Allen, Paul D., Stamatiou, Dimitrios, Dzau, Victor J., Liew, Choong-Chin
To obtain a genomic portrait of heart failure derived from end-stage dilated cardiomyopathy (DCM), we explored expression analysis using the CardioChip, a nonredundant 10,848-element human...
Ip, James E., Wu, Yaojiong, Huang, Jing, Zhang, Lunan, Pratt, Richard E., Dzau, Victor J.
Recent evidence has demonstrated the importance of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the repair of damaged myocardium. The molecular mechanisms of engraftment and migration of...