Vessela N. Kristensen

Gene expression analyses in breast cancer epidemiology: the Norwegian Women and Cancer postgenome cohort study (2008)

Dumeaux, Vanessa, Børresen-Dale, Anne-Lise, Frantzen, Jan-Ole, Kumle, Merethe, Kristensen, Vessela N, Lund, Eiliv

Abstract Introduction The introduction of high-throughput technologies, also called -omics technologies, into epidemiology has raised the need for high-quality observational studies to reduce several...

Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes (2007)

Nordgard, Silje H, Johansen, Fredrik E, Alnæs, Grethe IG, Naume, Bjørn, Børresen-Dale, Anne-Lise, Kristensen, Vessela N

Abstract Recently, genome-wide association studies of breast cancer revealed single nucleotide polymorphisms (SNPs) in five genes with novel association to susceptibility. While there is little doubt...

Linkage disequilibrium pattern of the ATMgene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence (2007)

Edvardsen, Hege, Tefre, Toril, Jansen, Laila, Vu, Phuong, Haffty, Bruce G, Fosså, Sophie D, ...

Abstract Background The ATM protein is activated as a result of ionizing radiation, and genetic variants of the ATM gene may therefore affect the level of radiation-induced damage. Individuals...

Multilocus analysis of SNP and metabolic data within a given pathway (2006)

Kristensen, Vessela N, Tsalenko, Anya, Geisler, Jurgen, Faldaas, Anne, Grenaker, Grethe, Lingjærde, Ole, ...

Abstract Background Complex traits, which are under the influence of multiple and possibly interacting genes, have become a subject of new statistical methodological research. One of the greatest...

Multilocus analysis of SNP and metabolic data within a given pathway (2006)

Kristensen, Vessela N., Tsalenko, Anya, Geisler, Jurgen, Faldaas, Anne, Grenaker, Grethe Irene, Lingjærde, Ole Christian, ...

Background: Complex traits, which are under the influence of multiple and possibly interacting genes, have become a subject of new statistical methodological research. One of the greatest challenges...

Single-track sequencing for genotyping of multiple SNPs in the N-acetyltransferase 1 (NAT1) gene (2004)

Soucek, Pavel, Skjelbred, Camilla, Svendsen, Marit, Kristensen, Tom, Kure, Elin H, Kristensen, Vessela N

Abstract Background Fast, cheap and reliable methods are needed to identify large populations, which may be at risk in relation to environmental exposure. Polymorphisms in NAT1 (N-acetyl transferase)...

Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer (2003)

Yoshimura, Noriko, Harada, Nobuhiro, Bukholm, Ida, Kåresen, Rolf, Børresen-Dale, Anne-Lise, Kristensen, Vessela N

Abstract Introduction The expression of the oestrogen receptor (ER) is one of the more important clinical parameters of breast cancer. However, the relationship between the ER and its ligand,...

Low frequency of E-cadherin alterations in familial breast cancer (2001)

Salahshor, Sima, Haixin, Lei, Huo, Huagang, Kristensen, Vessela N, Loman, Niklas, Sjöberg-Margolin, Sara, ...

Abstract In order to explore the possible role of E-cadherin in familial cancer, 19 familial breast cancer patients, whose tumours demonstrated loss of heterozygosity (LOH) at the E-cadherin locus,...

Low frequency of E-cadherin alterations in familial breast cancer (2001)

Salahshor, Sima, Haixin, Lei, Huo, Huagang, Kristensen, Vessela N., Loman, Niklas, Sjoberg-Margolin, Sara, ...

In order to explore the possible role of E-cadherin in familial cancer, 19 familial breast cancer patients, whose tumours demonstrated loss of heterozygosity (LOH) at the E-cadherin locus, were...

Low frequency of E-cadherin alterations in familial breast cancer

Salahshor, Sima, Haixin, Lei, Huo, Huagang, Kristensen, Vessela N, Loman, Niklas, Sjöberg-Margolin, Sara, ...

In order to explore the possible role of E-cadherin in familial cancer, 19 familial breast cancer patients, whose tumours demonstrated loss of heterozygosity (LOH) at the E-cadherin locus, were...

Genetic variation in putative regulatory loci controlling gene expression in breast cancer

Kristensen, Vessela N., Edvardsen, Hege, Tsalenko, Anya, Nordgard, Silje H., Sørlie, Therese, Sharan, Roded, ...

Candidate single-nucleotide polymorphisms (SNPs) were analyzed for associations to an unselected whole genome pool of tumor mRNA transcripts in 50 unrelated patients with breast cancer. SNPs were...

Low frequency of E-cadherin alterations in familial breast cancer

Salahshor, Sima, Haixin, Lei, Huo, Huagang, Kristensen, Vessela N, Loman, Niklas, Sjöberg-Margolin, Sara, ...

In order to explore the possible role of E-cadherin in familial cancer, 19 familial breast cancer patients, whose tumours demonstrated loss of heterozygosity (LOH) at the E-cadherin locus, were...

Genetic variation in putative regulatory loci controlling gene expression in breast cancer

Kristensen, Vessela N., Edvardsen, Hege, Tsalenko, Anya, Nordgard, Silje H., Sørlie, Therese, Sharan, Roded, ...

Candidate single-nucleotide polymorphisms (SNPs) were analyzed for associations to an unselected whole genome pool of tumor mRNA transcripts in 50 unrelated patients with breast cancer. SNPs were...

Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes

Nordgard, Silje H, Johansen, Fredrik E, Alnæs, Grethe IG, Naume, Bjørn, Børresen-Dale, Anne-Lise, Kristensen, Vessela N

Recently, genome-wide association studies of breast cancer revealed single nucleotide polymorphisms (SNPs) in five genes with novel association to susceptibility. While there is little doubt that the...

Features of 5′-splice-site efficiency derived from disease-causing mutations and comparative genomics

Roca, Xavier, Olson, Andrew J., Rao, Atmakuri R., Enerly, Espen, Kristensen, Vessela N., Børresen-Dale, Anne-Lise, ...

Many human diseases, including Fanconi anemia, hemophilia B, neurofibromatosis, and phenylketonuria, can be caused by 5′-splice-site (5′ss) mutations that are not predicted to disrupt splicing,...

Transcriptional Networks Inferred from Molecular Signatures of Breast Cancer

Tongbai, Ron, Idelman, Gila, Nordgard, Silje H., Cui, Wenwu, Jacobs, Jonathan L., Haggerty, Cynthia M., ...

Global genomic approaches in cancer research have provided new and innovative strategies for the identification of signatures that differentiate various types of human cancers. Computational analysis...