Uwe Christians

Coadministration of Either Cyclosporine or Steroids with Humanized Monoclonal Antibodies Against CD80 and CD86 Successfully Prolong Allograft Survival After Life Supporting Renal Transplantation in Cynomolgus Monkeys (1998)

Hausen, Bernad, Klupp, Jochen, Christians, Uwe, Higgins, John P., Baumgartner, Roxanne E.

Recent studies have shown some efficacy using monotherapy with monoclonal antibodies (mAb) against CD8O and CD86 receptors after life-supporting renal transplantation in non-human primates. Our study...

The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates

Serkova, Natalie, Litt, Lawrence, Leibfritz, Dieter, Hausen, Bernard, Morris, Randall E, James, Thomas L, ...

SDZ-RAD, 40-O-(2-hydroxyethyl)-rapamycin, is a novel macrolide immunosuppressant. Because of its synergistic interaction, SDZ-RAD is under clinical investigation as immunosuppressant in combination...

Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and Caco-2 cell monolayers

Soldner, Andrea, Benet, Leslie Z, Mutschler, Ernst, Christians, Uwe

We studied the functional interaction between transport and metabolism by comparing the transport of losartan and its active metabolite EXP 3174 (EXP) across cell monolayers.Epithelial layers of...

Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain

Serkova, Natalie, Jacobsen, Wolfgang, Niemann, Claus U, Litt, Lawrence, Benet, Leslie Z, Leibfritz, Dieter, ...

Clinical studies have shown enhancement of cyclosporine toxicity when co-administered with the immunosuppressant sirolimus. We evaluated the biochemical mechanisms underlying the...

Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors

Christians, Uwe, Gottschalk, Sven, Miljus, Jelena, Hainz, Carsten, Benet, Leslie Z, Leibfritz, Dieter, ...

Co-administration of the calcineurin inhibitor cyclosporine and the mTOR inhibitors sirolimus or everolimus increases the efficacy of immunosuppression after organ transplantation. However, clinical...