The role of endocytosis for pathogenic development of the corn smut fungus Ustilago maydis (2006)
It has long been established that fungal growth and pathogenic development are supported by exocytosis. However, the role of endocytosis during these growth processes has not been elucidated yet. It...
Endocytosis is essential for pathogenic development in the corn smut fungus Ustilago maydis. (2006)
Fuchs, Uta, Hause, Gerd, Schuchardt, Isabel, Steinberg, Gero
It is well established that polarized exocytosis is essential for fungal virulence. By contrast, the contribution of endocytosis is unknown. We made use of a temperature-sensitive mutant in the...
Fuchs, Uta, Manns, Isabella, Steinberg, Gero
Fungal pathogenicity often involves a yeast-to-hypha transition, but the structural basis for this dimorphism is largely unknown. Here we analyze the role of the cytoskeleton in early steps of...
Endocytosis in the plant-pathogenic fungus Ustilago maydis. (2005)
Filamentous fungi are an important group of tip-growing organisms, which include numerous plant pathogens such as Magnaporthe grisea and Ustilago maydis. Despite their ecological and economical...
Summary Microtubules are an important part of the eukaryotic cytoskeleton, which participates in numerous essential cellular processes. In fungi interphase microtubules mediate cell polarity and...
Charakterisierung der 11q23/MLL-Fusionspartnergene GRAF und FBP17 (2002)
Leukämien sind die häufigsten Krebserkrankungen im Kindesalter. Sie entstehen in den meisten Fällen aufgrund von chromosomalenTranslokationen, die die Struktur und normale Funktion von Genen...
Charakterisierung der 11q23/MLL-Fusionspartnergene GRAF und FBP17 (2002)
Leukämien sind die häufigsten Krebserkrankungen im Kindesalter. Sie entstehen in den meisten Fällen aufgrund von chromosomalen Translokationen, die die Struktur und normale Funktion von Genen...
Borkhardt, Arndt, Bojesen, Stig, Haas, Oskar A., Fuchs, Uta, Bartelheimer, Dominique, Loncarevic, Ivan F., ...
We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125FAK). This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant...
Fuchs, Uta, Rehkamp, Gönna, Haas, Oskar A., Slany, Robert, König, Margit, Bojesen, Stig, ...
We have cloned a fusion partner of the MLL gene at 11q23 and identified it as the gene encoding the human formin-binding protein 17, FBP17. It maps to chromosome 9q34 centromeric to ABL. The gene...
Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization
Zeisig, Bernd B., Milne, Tom, García-Cuéllar, María-Paz, Schreiner, Silke, Martin, Mary-Ellen, Fuchs, Uta, ...
MLL fusion proteins are oncogenic transcription factors that are associated with aggressive lymphoid and myeloid leukemias. We constructed an inducible MLL fusion, MLL-ENL-ERtm, that rendered the...
Fuchs, Uta, Manns, Isabel, Steinberg, Gero
Fungal pathogenicity often involves a yeast-to-hypha transition, but the structural basis for this dimorphism is largely unknown. Here we analyze the role of the cytoskeleton in early steps of...
Borkhardt, Arndt, Bojesen, Stig, Haas, Oskar A., Fuchs, Uta, Bartelheimer, Dominique, Loncarevic, Ivan F., ...
We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125FAK). This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant...
Fuchs, Uta, Rehkamp, Gönna, Haas, Oskar A., Slany, Robert, König, Margit, Bojesen, Stig, ...
We have cloned a fusion partner of the MLL gene at 11q23 and identified it as the gene encoding the human formin-binding protein 17, FBP17. It maps to chromosome 9q34 centromeric to ABL. The gene...
Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization
Zeisig, Bernd B., Milne, Tom, García-Cuéllar, María-Paz, Schreiner, Silke, Martin, Mary-Ellen, Fuchs, Uta, ...
MLL fusion proteins are oncogenic transcription factors that are associated with aggressive lymphoid and myeloid leukemias. We constructed an inducible MLL fusion, MLL-ENL-ERtm, that rendered the...
Fuchs, Uta, Manns, Isabel, Steinberg, Gero
Fungal pathogenicity often involves a yeast-to-hypha transition, but the structural basis for this dimorphism is largely unknown. Here we analyze the role of the cytoskeleton in early steps of...
c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells
Hess, Jay L., Bittner, Claudia B., Zeisig, Deniz T., Bach, Christian, Fuchs, Uta, Borkhardt, Arndt, ...
Abdominal-type HoxA genes in combination with Meis1 are well-documented on-cogenes in various leukemias but it is unclear how they exert their transforming function. Here we used a system of...
Endocytosis Is Essential for Pathogenic Development in the Corn Smut Fungus Ustilago maydis[W]
Fuchs, Uta, Hause, Gerd, Schuchardt, Isabel, Steinberg, Gero
It is well established that polarized exocytosis is essential for fungal virulence. By contrast, the contribution of endocytosis is unknown. We made use of a temperature-sensitive mutant in the...
Wossning, Thomas, Herzog, Sebastian, Köhler, Fabian, Meixlsperger, Sonja, Kulathu, Yogesh, Mittler, Gerhard, ...
The nonreceptor protein spleen tyrosine kinase (Syk) is a key mediator of signal transduction in a variety of cell types, including B lymphocytes. We show that deregulated Syk activity allows growth...