Ulrik Lademann

Diarylurea Compounds Inhibit Caspase Activation by Preventing the Formation of the Active 700-Kilodalton Apoptosome Complex

Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja

The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...

Diarylurea Compounds Inhibit Caspase Activation by Preventing the Formation of the Active 700-Kilodalton Apoptosome Complex

Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja

The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...

Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

Nylandsted, Jesper, Gyrd-Hansen, Mads, Danielewicz, Agnieszka, Fehrenbacher, Nicole, Lademann, Ulrik, Høyer-Hansen, Maria, ...

Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by...

Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor

Foghsgaard, Lasse, Wissing, Dorte, Mauch, Daniel, Lademann, Ulrik, Bastholm, Lone, Boes, Marianne, ...

Death receptors can trigger cell demise dependent or independent of caspases. In WEHI-S fibrosarcoma cells, tumor necrosis factor (TNF) induced an increase in cytosolic cathepsin B activity followed...