Ulf Hellman

Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. (2003)

Demoulin, Jean-Baptiste, Seo, Jeong Kon, Ekman, Simon, Grapengiesser, Eva, Hellman, Ulf, Rönnstrand, Lars, ...

Proteins interacting with the human PDGF (platelet-derived growth factor) b-receptor were isolated using immobilized peptides derived from the receptor C-terminus as a bait. We identified two PDZ...

Mitochondrial ATP synthase--a possible target protein in the regulation of energy metabolism in vitro and in vivo. (2002)

Berger, Karin, Sivars, Ulf, Sörhede Winzell, Maria, Johansson, Peter, Hellman, Ulf, Rippe, Catarina, ...

The increasing prevalence of obesity in the Western world has stimulated an intense search for mechanisms regulating food intake and energy balance. A number of appetite-regulating peptides have been...

Cloning and functional characterization of a subunit of the transporter associated with antigen processing

Li, Suling, Sjögren, Hans-Olov, Hellman, Ulf, Pettersson, Ralf F., Wang, Ping

The transporter associated with antigen processing (TAP) is essential for the transport of antigenic peptides across the membrane of the endoplasmic reticulum. In addition, TAP interacts with major...

B12-dependent ribonucleotide reductases from deeply rooted eubacteria are structurally related to the aerobic enzyme from Escherichia coli

Jordan, Albert, Torrents, Eduard, Jeanthon, Christian, Eliasson, Rolf, Hellman, Ulf, Wernstedt, Christer, ...

The ribonucleotide reductases from three ancient eubacteria, the hyperthermophilic Thermotoga maritima (TM), the radioresistant Deinococcus radiodurans (DR), and the thermophilic photosynthetic...

Ribonucleotide Reduction in Pseudomonas Species: Simultaneous Presence of Active Enzymes from Different Classes

Jordan, Albert, Torrents, Eduard, Sala, Irma, Hellman, Ulf, Gibert, Isidre, Reichard, Peter

Three separate classes of ribonucleotide reductases exist in nature. They differ widely in protein structure. Class I enzymes are found in aerobic bacteria and eukaryotes; class II enzymes are found...

Evidence for a Posttranscriptional Role of a TFIIICα-like Protein in Chironomus tentans

Sabri, Nafiseh, Farrants, Ann-Kristin Östlund, Hellman, Ulf, Visa, Neus

We have cloned and sequenced a cDNA that encodes for a nuclear protein of 238 kDa in the dipteran Chironomus tentans. This protein, that we call p2D10, is structurally similar to the α subunit of...

Functional proteomics of transforming growth factor-β1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFβ1-dependent regulation of DNA repair

Kanamoto, Takashi, Hellman, Ulf, Heldin, Carl-Henrik, Souchelnytskyi, Serhiy

Transforming growth factor-β (TGFβ) conveys regulatory signals through multiple intracellular pathways, subsequently affecting various cellular functions. To identify new targets for TGFβ, we...

A Novel Conserved RNA-binding Domain Protein, RBD-1, Is Essential For Ribosome Biogenesis

Björk, Petra, Baurén, Göran, Jin, ShaoBo, Tong, Yong-Guang, Bürglin, Thomas R., Hellman, Ulf, ...

Synthesis of the ribosomal subunits from pre-rRNA requires a large number of trans-acting proteins and small nucleolar ribonucleoprotein particles to execute base modifications, RNA cleavages, and...

Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases

Persson, Camilla, Sjöblom, Tobias, Groen, Arnoud, Kappert, Kai, Engström, Ulla, Hellman, Ulf, ...

Protein tyrosine phosphatases (PTPs) constitute a large enzyme family with important biological functions. Inhibition of PTP activity through reversible oxidation of the active-site cysteine residue...

Echinococcus granulosus antigen 5 is closely related to proteases of the trypsin family.

Lorenzo, Carmen, Salinas, Gustavo, Brugnini, Andreina, Wernstedt, Christer, Hellman, Ulf, González-Sapienza, Gualberto

Antigen 5 (Ag5) is a dominant secreted component of the larval stage of Echinococcus granulosus, and is highly immunogenic in human infections. Although the diagnostic value of Ag5 has been...

Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF.

Demoulin, Jean-Baptiste, Seo, Jeong Kon, Ekman, Simon, Grapengiesser, Eva, Hellman, Ulf, Rönnstrand, Lars, ...

Proteins interacting with the human PDGF (platelet-derived growth factor) beta-receptor were isolated using immobilized peptides derived from the receptor C-terminus as a bait. We identified two PDZ...

Phosphoproteome Profiling of Transforming Growth Factor (TGF)-β Signaling: Abrogation of TGFβ1-dependent Phosphorylation of Transcription Factor-II-I (TFII-I) Enhances Cooperation of TFII-I and Smad3 in TranscriptionD⃞

Stasyk, Taras, Dubrovska, Anna, Lomnytska, Marta, Yakymovych, Ihor, Wernstedt, Christer, Heldin, Carl-Henrik, ...

Transforming growth factor-β (TGFβ) signaling involves activation of a number of signaling pathways, several of which are controlled by phosphorylation events. Here, we describe a phosphoproteome...

Cloning and functional characterization of a subunit of the transporter associated with antigen processing

Li, Suling, Sjögren, Hans-Olov, Hellman, Ulf, Pettersson, Ralf F., Wang, Ping

The transporter associated with antigen processing (TAP) is essential for the transport of antigenic peptides across the membrane of the endoplasmic reticulum. In addition, TAP interacts with major...

B12-dependent ribonucleotide reductases from deeply rooted eubacteria are structurally related to the aerobic enzyme from Escherichia coli

Jordan, Albert, Torrents, Eduard, Jeanthon, Christian, Eliasson, Rolf, Hellman, Ulf, Wernstedt, Christer, ...

The ribonucleotide reductases from three ancient eubacteria, the hyperthermophilic Thermotoga maritima (TM), the radioresistant Deinococcus radiodurans (DR), and the thermophilic photosynthetic...

Ribonucleotide Reduction in Pseudomonas Species: Simultaneous Presence of Active Enzymes from Different Classes

Jordan, Albert, Torrents, Eduard, Sala, Irma, Hellman, Ulf, Gibert, Isidre, Reichard, Peter

Three separate classes of ribonucleotide reductases exist in nature. They differ widely in protein structure. Class I enzymes are found in aerobic bacteria and eukaryotes; class II enzymes are found...

Evidence for a Posttranscriptional Role of a TFIIICα-like Protein in Chironomus tentans

Sabri, Nafiseh, Farrants, Ann-Kristin Östlund, Hellman, Ulf, Visa, Neus

We have cloned and sequenced a cDNA that encodes for a nuclear protein of 238 kDa in the dipteran Chironomus tentans. This protein, that we call p2D10, is structurally similar to the α subunit of...

Functional proteomics of transforming growth factor-β1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFβ1-dependent regulation of DNA repair

Kanamoto, Takashi, Hellman, Ulf, Heldin, Carl-Henrik, Souchelnytskyi, Serhiy

Transforming growth factor-β (TGFβ) conveys regulatory signals through multiple intracellular pathways, subsequently affecting various cellular functions. To identify new targets for TGFβ, we...

A Novel Conserved RNA-binding Domain Protein, RBD-1, Is Essential For Ribosome Biogenesis

Björk, Petra, Baurén, Göran, Jin, ShaoBo, Tong, Yong-Guang, Bürglin, Thomas R., Hellman, Ulf, ...

Synthesis of the ribosomal subunits from pre-rRNA requires a large number of trans-acting proteins and small nucleolar ribonucleoprotein particles to execute base modifications, RNA cleavages, and...

Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases

Persson, Camilla, Sjöblom, Tobias, Groen, Arnoud, Kappert, Kai, Engström, Ulla, Hellman, Ulf, ...

Protein tyrosine phosphatases (PTPs) constitute a large enzyme family with important biological functions. Inhibition of PTP activity through reversible oxidation of the active-site cysteine residue...

Echinococcus granulosus antigen 5 is closely related to proteases of the trypsin family.

Lorenzo, Carmen, Salinas, Gustavo, Brugnini, Andreina, Wernstedt, Christer, Hellman, Ulf, González-Sapienza, Gualberto

Antigen 5 (Ag5) is a dominant secreted component of the larval stage of Echinococcus granulosus, and is highly immunogenic in human infections. Although the diagnostic value of Ag5 has been...

Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF.

Demoulin, Jean-Baptiste, Seo, Jeong Kon, Ekman, Simon, Grapengiesser, Eva, Hellman, Ulf, Rönnstrand, Lars, ...

Proteins interacting with the human PDGF (platelet-derived growth factor) beta-receptor were isolated using immobilized peptides derived from the receptor C-terminus as a bait. We identified two PDZ...

Phosphoproteome Profiling of Transforming Growth Factor (TGF)-β Signaling: Abrogation of TGFβ1-dependent Phosphorylation of Transcription Factor-II-I (TFII-I) Enhances Cooperation of TFII-I and Smad3 in TranscriptionD⃞

Stasyk, Taras, Dubrovska, Anna, Lomnytska, Marta, Yakymovych, Ihor, Wernstedt, Christer, Heldin, Carl-Henrik, ...

Transforming growth factor-β (TGFβ) signaling involves activation of a number of signaling pathways, several of which are controlled by phosphorylation events. Here, we describe a phosphoproteome...

p53 targets identified by protein expression profiling

Rahman-Roblick, Rubaiyat, Johannes Roblick, Uwe, Hellman, Ulf, Conrotto, Paolo, Liu, Tao, Becker, Susanne, ...

p53 triggers cell cycle arrest and apoptosis through transcriptional regulation of specific target genes. We have investigated the effect of p53 activation on the proteome using 2D gel...

Electron Tomography Reveals Posttranscriptional Binding of Pre-Mrnps to Specific Fibers in the Nucleoplasm

Miralles, Francesc, Öfverstedt, Lars-Göran, Sabri, Nafiseh, Aissouni, Youssef, Hellman, Ulf, Skoglund, Ulf, ...

Using electron tomography, we have analyzed whether the Balbiani ring (BR) pre-mRNP particles in transit from the gene to the nuclear pore complex (NPC) are bound to any structure that could impair...

Sulfonation Chemistry as a Powerful Tool for MALDI TOF/TOF de Novo Sequencing and Post-Translational Modification Analysis

Conrotto, Paolo, Hellman, Ulf

Mass spectrometry using matrix-assisted laser desorption/ionization (MALDI) is a widespread technique for various types of proteomic analysis. In the identification of proteins using peptide mass...