Torsten O. Nielsen

Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy (2007)

Stratford, Anna L, Habibi, Golareh, Astanehe, Arezoo, Jiang, Helen, Hu, Kaiji, Park, Eugene, ...

Abstract Introduction Basal-like breast cancers (BLBCs) are very aggressive, and present serious clinical challenges as there are currently no targeted therapies available. We determined the...

Use of immunohistochemical markers can refine prognosis in triple negative breast cancer (2007)

Tischkowitz, Marc, Brunet, Jean-Sébastien, Bégin, Louis R, Huntsman, David G, Cheang, Maggie CU, Akslen, Lars A, ...

Abstract Background Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the...

Use of immunohistochemical markers can refine prognosis in triple negative breast cancer (2007)

Tischkowitz, Marc, Brunet, Jean-Sébastien, Bégin, Louis R., Huntsman, David G., Cheang, Maggie C. U., Akslen, Lars A., ...

Background: Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the basis of...

Determination of Stromal Signatures in Breast Carcinoma (2005)

Robert B. West, Subbaya Subramanian, Torsten O. Nielsen, Christopher L. Corless, Brian P. Rubin, ...

The authors used two different fibroblastic tumors to identify markers expressed by normal stroma cells (the supporting framework of body tissues and/or tumors), and show that different stromal...

Determination of Stromal Signatures in Breast Carcinoma (2005)

Robert B. West, Subbaya Subramanian, Torsten O. Nielsen, Christopher L. Corless, Brian P. Rubin, ...

Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...

Determination of Stromal Signatures in Breast Carcinoma

West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...

Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...

αB-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer

Moyano, Jose V., Evans, Joseph R., Chen, Feng, Lu, Meiling, Werner, Michael E., Yehiely, Fruma, ...

Recent gene profiling studies have identified a new breast cancer subtype, the basal-like group, which expresses genes characteristic of basal epithelial cells and is associated with poor clinical...

A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells

West, Robert B., Rubin, Brian P., Miller, Melinda A., Subramanian, Subbaya, Kaygusuz, Gulsah, Montgomery, Kelli, ...

Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations....

Determination of Stromal Signatures in Breast Carcinoma

West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...

Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...

αB-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer

Moyano, Jose V., Evans, Joseph R., Chen, Feng, Lu, Meiling, Werner, Michael E., Yehiely, Fruma, ...

Recent gene profiling studies have identified a new breast cancer subtype, the basal-like group, which expresses genes characteristic of basal epithelial cells and is associated with poor clinical...

A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells

West, Robert B., Rubin, Brian P., Miller, Melinda A., Subramanian, Subbaya, Kaygusuz, Gulsah, Montgomery, Kelli, ...

Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations....

The Novel Marker, DOG1, Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status

West, Robert B., Corless, Christopher L., Chen, Xin, Rubin, Brian P., Subramanian, Subbaya, Montgomery, Kelli, ...

We recently characterized gene expression patterns in gastrointestinal stromal tumors (GISTs) using cDNA microarrays, and found that the gene FLJ10261 (DOG1, discovered on GIST-1), encoding a...

Tissue Microarray Validation of Epidermal Growth Factor Receptor and SALL2 in Synovial Sarcoma with Comparison to Tumors of Similar Histology

Nielsen, Torsten O., Hsu, Forrest D., O’Connell, John X., Gilks, C. Blake, Sorensen, Poul H.B., Linn, Sabine, ...

Histological diagnosis of synovial sarcoma can be difficult. Genome-wide expression profiling has identified a number of genes expressed at higher levels in synovial sarcoma than in other soft tissue...

Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans

Linn, Sabine C., West, Rob B., Pollack, Jonathan R., Zhu, Shirley, Hernandez-Boussard, Tina, Nielsen, Torsten O., ...

Dermatofibrosarcoma protuberans (DFSP) is an aggressive spindle cell neoplasm. It is associated with the chromosomal translocation, t(17:22), which fuses the COL1A1 and PDGFβ genes. We determined...