Szczepek, Michal, Brondani, Vincent, Büchel, Janine, Serrano, Luis, Segal, David J, Cathomen, Toni
Artificial endonucleases consisting of a Fokl cleavage domain tethered to engineered zinc-finger DNA-binding proteins have proven useful for stimulating homologous recombination in a variety of cell...
Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks (2003)
Porteus, Matthew H., Cathomen, Toni, Weitzman, Matthew D., Baltimore, David
Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly...
Schlender, Jörg, Schnorr, Jens-Jörg, Spielhofer, Pius, Cathomen, Toni, Cattaneo, Roberto, Billeter, Martin A., ...
A marked suppression of immune function has long been recognized as a major cause of the high morbidity and mortality rate associated with acute measles. As a hallmark of measles virus (MV)-induced...
A genetic screen identifies a cellular regulator of adeno-associated virus
Cathomen, Toni, Stracker, Travis H., Gilbert, Luz Beatriz, Weitzman, Matthew D.
Adeno-associated virus type 2 (AAV2) is a human parvovirus that has attracted attention as a vector for gene transfer. Replication and site-specific integration of the wild-type virus requires...
Cathomen, Toni, Collete, Delphine, Weitzman, Matthew D.
The Rep78 and Rep68 proteins of adeno-associated virus (AAV) type 2 are involved in DNA replication, regulation of gene expression, and targeting site-specific integration. They bind to a specific...
Grifman, Mirta, Chen, Nancie N., Gao, Guang-ping, Cathomen, Toni, Wilson, James M., Weitzman, Matthew D.
The 34-kDa product of adenovirus E4 region open reading frame 6 (E4orf6) dramatically enhances transduction by recombinant adeno-associated virus vectors (rAAV). This is achieved by promoting the...
Cathomen, Toni, Weitzman, Matthew D.
In adenovirus-infected cells, binding of E1B-55kDa and E4orf6 to the tumor suppressor protein p53 inhibits its transcriptional activity and causes rapid turnover of the protein. To investigate the...
Measles Viruses with Altered Envelope Protein Cytoplasmic Tails Gain Cell Fusion Competence
Cathomen, Toni, Naim, Hussein Y., Cattaneo, Roberto
The cytoplasmic tail of the measles virus (MV) fusion (F) protein is often altered in viruses which spread through the brain of patients suffering from subacute sclerosing panencephalitis (SSPE). We...
Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks
Porteus, Matthew H., Cathomen, Toni, Weitzman, Matthew D., Baltimore, David
Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly...
Schlender, Jörg, Schnorr, Jens-Jörg, Spielhofer, Pius, Cathomen, Toni, Cattaneo, Roberto, Billeter, Martin A., ...
A marked suppression of immune function has long been recognized as a major cause of the high morbidity and mortality rate associated with acute measles. As a hallmark of measles virus (MV)-induced...
A genetic screen identifies a cellular regulator of adeno-associated virus
Cathomen, Toni, Stracker, Travis H., Gilbert, Luz Beatriz, Weitzman, Matthew D.
Adeno-associated virus type 2 (AAV2) is a human parvovirus that has attracted attention as a vector for gene transfer. Replication and site-specific integration of the wild-type virus requires...
Cathomen, Toni, Collete, Delphine, Weitzman, Matthew D.
The Rep78 and Rep68 proteins of adeno-associated virus (AAV) type 2 are involved in DNA replication, regulation of gene expression, and targeting site-specific integration. They bind to a specific...
Grifman, Mirta, Chen, Nancie N., Gao, Guang-ping, Cathomen, Toni, Wilson, James M., Weitzman, Matthew D.
The 34-kDa product of adenovirus E4 region open reading frame 6 (E4orf6) dramatically enhances transduction by recombinant adeno-associated virus vectors (rAAV). This is achieved by promoting the...
Cathomen, Toni, Weitzman, Matthew D.
In adenovirus-infected cells, binding of E1B-55kDa and E4orf6 to the tumor suppressor protein p53 inhibits its transcriptional activity and causes rapid turnover of the protein. To investigate the...
Measles Viruses with Altered Envelope Protein Cytoplasmic Tails Gain Cell Fusion Competence
Cathomen, Toni, Naim, Hussein Y., Cattaneo, Roberto
The cytoplasmic tail of the measles virus (MV) fusion (F) protein is often altered in viruses which spread through the brain of patients suffering from subacute sclerosing panencephalitis (SSPE). We...
Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks
Porteus, Matthew H., Cathomen, Toni, Weitzman, Matthew D., Baltimore, David
Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly...