The UPS: a promising target for breast cancer treatment (2008)
Sato, Ko, Rajendra, Eeson, Ohta, Tomohiko
Abstract During the past decade, progress in endocrine therapy and the use of trastuzumab has significantly contributed to the decline in breast cancer mortality for hormone receptor-positive and...
The ubiquitin E3 ligase activity of BRCA1 and its biological functions (2008)
Wu, Wenwen, Koike, Ayaka, Takeshita, Takashi, Ohta, Tomohiko
Abstract The basal-like breast cancer, a new category of breast cancer associated with poor prognosis and possibly unique chemosensitivity, is a current topic in the breast cancer field. Evidence...
Whitfield, Michael L., Zheng, Lian-Xing, Baldwin, Amy, Ohta, Tomohiko, Hurt, Myra M., Marzluff, William F.
The expression of the replication-dependent histone mRNAs is tightly regulated during the cell cycle. As cells progress from G1 to S phase, histone mRNA levels increase 35-fold, and they decrease...
Furukawa, Manabu, Zhang, Yanping, McCarville, Joseph, Ohta, Tomohiko, Xiong, Yue
Members of the cullin and RING finger ROC protein families form heterodimeric complexes to constitute a potentially large number of distinct E3 ubiquitin ligases. We report here that the highly...
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex
Brzovic, Peter S., Keeffe, Jennifer R., Nishikawa, Hiroyuki, Miyamoto, Keiko, Fox, David, Fukuda, Mamoru, ...
BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with...
Whitfield, Michael L., Zheng, Lian-Xing, Baldwin, Amy, Ohta, Tomohiko, Hurt, Myra M., Marzluff, William F.
The expression of the replication-dependent histone mRNAs is tightly regulated during the cell cycle. As cells progress from G1 to S phase, histone mRNA levels increase 35-fold, and they decrease...
Furukawa, Manabu, Zhang, Yanping, McCarville, Joseph, Ohta, Tomohiko, Xiong, Yue
Members of the cullin and RING finger ROC protein families form heterodimeric complexes to constitute a potentially large number of distinct E3 ubiquitin ligases. We report here that the highly...
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex
Brzovic, Peter S., Keeffe, Jennifer R., Nishikawa, Hiroyuki, Miyamoto, Keiko, Fox, David, Fukuda, Mamoru, ...
BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with...
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin'
Yamasaki, Satoshi, Yagishita, Naoko, Sasaki, Takeshi, Nakazawa, Minako, Kato, Yukihiro, Yamadera, Tadayuki, ...
Synoviolin, also called HRD1, is an E3 ubiquitin ligase and is implicated in endoplasmic reticulum -associated degradation. In mammals, Synoviolin plays crucial roles in various physiological and...
The ubiquitin E3 ligase activity of BRCA1 and its biological functions
Wu, Wenwen, Koike, Ayaka, Takeshita, Takashi, Ohta, Tomohiko
The basal-like breast cancer, a new category of breast cancer associated with poor prognosis and possibly unique chemosensitivity, is a current topic in the breast cancer field. Evidence from...
The UPS: a promising target for breast cancer treatment
Sato, Ko, Rajendra, Eeson, Ohta, Tomohiko
During the past decade, progress in endocrine therapy and the use of trastuzumab has significantly contributed to the decline in breast cancer mortality for hormone receptor-positive and ERBB2...