Tom Larsen

Development of a New Vaccine for the Prevention of Lassa Fever (2005)

Thomas W. Geisbert, Steven Jones, Elizabeth A. Fritz, Amy C. Shurtleff, Joan B. Geisbert, Ryan Liebscher, ...

A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.

Development of a New Vaccine for the Prevention of Lassa Fever (2005)

Thomas W. Geisbert, Steven Jones, Elizabeth A. Fritz, Amy C. Shurtleff, Joan B. Geisbert, Ryan Liebscher, ...

Background Recent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health...

Filovirus Pathogenesis in Nonhuman Primates (1998)

Geisbert, Thomas W., Jahrling, Peter B., Larsen, Tom, Davis, Kelly J., Hensley, Lisa

Infections with Ebola and Marburg viruses cause severe and fatal hemorrhagic disease in humans and nonhuman primates. While progress to define the mechanisms of filoviral pathogenesis has been made...

Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques (1998)

Geisbert, Thomas W., Hensley, Lisa E., Larsen, Tom, Young, Howard A., Reed, Douglas S.

Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of...

Treatment of Ebola Virus Infection With a Recombinant Inhibitor of Factor Vlla/Tissue Factor: A Study in Rhesus Monkeys (1998)

Geisbert, Thomas W., Hensley, Lisa E., Jahrling, Peter B., Larsen, Tom, Geisbert, Joan B.

Infection with the Ebola virus induces overexpression of the procoagulant tissue factor in primate monocytes and macrophages, suggesting that inhibition of the tissue-factor pathway could ameliorate...

Human Leukocyte Antigen-DQ8 Transgenic Mice: A Model to Examine the Toxicity of Aerosolized Staphylococcal Enterotoxin B (1998)

Roy, Chad J., Warfield, Kelly L., Welcher, Brent C., Gonzales, Raoul F., Larsen, Tom, Hanson, Julie, ...

Staphylococcal enterotoxins (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especially when delivered as an aerosol. SEs elicit the release of lethal amounts...

Aerosol Exposure to Western Equine Encephalitis Virus Causes Fever and Encephalitis in Cynomolgus Macaques (1998)

Reed, Douglas S., Larsen, Tom, Sullivan, Lawrence J., Lind, Cathleen M., Lackemeyer, Matthew G., Pratt, William D., ...

Cynomolgus macaques were exposed by aerosol to a virulent strain of western equine encephalitis virus (WEEV). Between 4 and 6 days after exposure, macaques had a significantly elevated temperature...

Human Leukocyte Antigen-DQ8 Transgenic Mice: a Model To Examine the Toxicity of Aerosolized Staphylococcal Enterotoxin B

Roy, Chad J., Warfield, Kelly L., Welcher, Brent C., Gonzales, Raoul F., Larsen, Tom, Hanson, Julie, ...

Staphylococcal enterotoxins (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especially when delivered as an aerosol. SEs elicit the release of lethal amounts...

Development of a New Vaccine for the Prevention of Lassa Fever

Geisbert, Thomas W, Jones, Steven, Fritz, Elizabeth A, Shurtleff, Amy C, Geisbert, Joan B, Liebscher, Ryan, ...

A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.

Human Leukocyte Antigen-DQ8 Transgenic Mice: a Model To Examine the Toxicity of Aerosolized Staphylococcal Enterotoxin B

Roy, Chad J., Warfield, Kelly L., Welcher, Brent C., Gonzales, Raoul F., Larsen, Tom, Hanson, Julie, ...

Staphylococcal enterotoxins (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especially when delivered as an aerosol. SEs elicit the release of lethal amounts...

Development of a New Vaccine for the Prevention of Lassa Fever

Geisbert, Thomas W, Jones, Steven, Fritz, Elizabeth A, Shurtleff, Amy C, Geisbert, Joan B, Liebscher, Ryan, ...

A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.

Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques: Evidence that Dendritic Cells Are Early and Sustained Targets of Infection

Geisbert, Thomas W., Hensley, Lisa E., Larsen, Tom, Young, Howard A., Reed, Douglas S., Geisbert, Joan B., ...

Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of...

Pathogenesis of Ebola Hemorrhagic Fever in Primate Models : Evidence that Hemorrhage Is Not a Direct Effect of Virus-Induced Cytolysis of Endothelial Cells

Geisbert, Thomas W., Young, Howard A., Jahrling, Peter B., Davis, Kelly J., Larsen, Tom, Kagan, Elliott, ...

Ebola virus (EBOV) infection causes a severe and often fatal hemorrhagic disease in humans and nonhuman primates. Whether infection of endothelial cells is central to the pathogenesis of EBOV...

Temporal Analysis of Andes Virus and Sin Nombre Virus Infections of Syrian Hamstersâ–ż

Wahl-Jensen, Victoria, Chapman, Jennifer, Asher, Ludmila, Fisher, Robert, Zimmerman, Michael, Larsen, Tom, ...

Andes virus (ANDV) and Sin Nombre virus (SNV) are rodent-borne hantaviruses that cause a highly lethal hemorrhagic fever in humans known as hantavirus pulmonary syndrome (HPS). There are no vaccines...