A Novel Inhibitory Mechanism of Mitochondrion-Dependent Apoptosis by a Herpesviral Protein (2007)
Pinghui Feng, Chengyu Liang, Young C. Shin, Xiaofei E, Weijun Zhang, Robyn Gravel, ...
Upon viral infection, cells undergo apoptosis as a defense against viral replication. Viruses, in turn, have evolved elaborate mechanisms to subvert apoptotic processes. Here, we report that a novel...
Fuqu Yu, Josephine N. Harada, Helen J. Brown, Hongyu Deng, Moon Jung Song, Ting-Ting Wu, ...
The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It is believed that cellular signals...
Variations on the RNA genome of hepatitis delta virus (1997)
Hepatitis delta virus (HDV) is a subviral satellite of hepatitis B virus. The unique HDV genome is a single-stranded circular RNA of 1679 nucleotides and can fold into an unbranched rodlike structure...
Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from Latency
Wu, Ting-Ting, Usherwood, Edward J., Stewart, James P., Nash, Anthony A., Sun, Ren
Herpesviruses are characterized as having two distinct life cycle phases: lytic replication and latency. The mechanisms of latency establishment and maintenance, as well as the switch from latency to...
Gudima, Severin, Dingle, Kate, Wu, Ting-Ting, Moraleda, Gloria, Taylor, John
The genome of hepatitis delta virus (HDV) is a 1,679-nucleotide (nt) single-stranded circular RNA that is predicted to fold into an unbranched rodlike structure. During replication, two complementary...
Song, Moon Jung, Brown, Helen J., Wu, Ting-Ting, Sun, Ren
Human herpesvirus 8 (HHV-8) (also known as Kaposi's sarcoma-associated herpesvirus) encodes a novel noncoding polyadenylated nuclear (PAN) RNA (also known as T1.1 or nut-1) during the early phase of...
Function of Rta Is Essential for Lytic Replication of Murine Gammaherpesvirus 68
Wu, Ting-Ting, Tong, Leming, Rickabaugh, Tammy, Speck, Samuel, Sun, Ren
Rta, encoded primarily by open reading frame 50, is well conserved among gammaherpesviruses. It has been shown that the Rta proteins of Epstein Barr virus (EBV), Kaposi's sarcoma-associated...
NF-κB Inhibits Gammaherpesvirus Lytic Replication
Brown, Helen J., Song, Moon Jung, Deng, Hongyu, Wu, Ting-Ting, Cheng, Genhong, Sun, Ren
Nasopharyngeal carcinoma, Kaposi's sarcoma, and B-cell lymphomas are human malignancies associated with gammaherpesvirus infections. Members of this virus family are characterized by their ability to...
Transcription Program of Murine Gammaherpesvirus 68
Martinez-Guzman, DeeAnn, Rickabaugh, Tammy, Wu, Ting-Ting, Brown, Helen, Cole, Steven, Song, Moon Jung, ...
Murine gammaherpesvirus 68 (MHV-68 [also referred to as γHV68]) is phylogenetically related to Kaposi's sarcoma-associated herpesvirus (KSHV [also referred to as HHV-8]) and Epstein-Barr virus...
Symensma , Tonia L., Martinez-Guzman, DeeAnn, Jia, Qingmei, Bortz, Eric, Wu, Ting-Ting, Rudra-Ganguly, Nandini, ...
The murine gammaherpesvirus 68 (MHV-68 or γHV-68) model provides many advantages for studying virus-host interactions involved in gammaherpesvirus replication, including the role of cellular...
Identification of Proteins Associated with Murine Gammaherpesvirus 68 Virions
Bortz, Eric, Whitelegge, Julian P., Jia, Qingmei, Zhou, Z. Hong, Stewart, James P., Wu, Ting-Ting, ...
Murine gammaherpesvirus 68 (MHV68 [also known as γHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying...
Murine Gammaherpesvirus 68 Open Reading Frame 31 Is Required for Viral Replication
Jia, Qingmei, Wu, Ting-Ting, Liao, Hsiang-I, Chernishof, Vasili, Sun, Ren
Murine gammaherpesvirus 68 (MHV-68) is genetically related to the human gammaherpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) and Epstein-Barr virus (EBV). It has been proposed as...
Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary Infection
Rickabaugh, Tammy M., Brown, Helen J., Martinez-Guzman, DeeAnn, Wu, Ting-Ting, Tong, Leming, Yu, Fuqu, ...
Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus-68 (MHV-68) establish latent infections and are associated with various types of malignancies. They are members of the gamma-2...
Ng, Alan K., Block, Timothy M., Aiamkitsumrit, Benjamas, Wang, Mengjun, Clementi, Emily, Wu, Ting-Ting, ...
Previous studies using a eukaryotic expression system indicated that the unusual stability of the latency-associated transcript (LAT) intron was due to its nonconsensus branchpoint sequence (T.-T Wu,...
Rickabaugh, Tammy M., Brown, Helen J., Wu, Ting-Ting, Song, Moon Jung, Hwang, Seungmin, Deng, Hongyu, ...
Murine gammaherpesvirus 68 (MHV-68), Kaposi's sarcoma-associated herpesvirus (HHV-8), and Epstein-Barr virus (EBV) are all members of the gammaherpesvirus family, characterized by their ability to...
Song, Moon Jung, Hwang, Seungmin, Wong, Wendy H., Wu, Ting-Ting, Lee, Sangmi, Liao, Hsiang-I, ...
γ-Herpesviruses, Epstein–Barr virus, and Kaposi's sarcoma-associated herpesvirus are important human pathogens, because they are involved in tumor development. Murine γ-herpesvirus-68 (MHV-68 or...
Jia, Qingmei, Chernishof, Vasili, Bortz, Eric, Mchardy, Ian, Wu, Ting-Ting, Liao, Hsiang-I, ...
Murine gammaherpesvirus 68 (MHV-68) has been developed as a model for the human gammaherpesviruses Epstein-Barr virus and human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus (HHV-8/KSHV),...
Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from Latency
Wu, Ting-Ting, Usherwood, Edward J., Stewart, James P., Nash, Anthony A., Sun, Ren
Herpesviruses are characterized as having two distinct life cycle phases: lytic replication and latency. The mechanisms of latency establishment and maintenance, as well as the switch from latency to...
Gudima, Severin, Dingle, Kate, Wu, Ting-Ting, Moraleda, Gloria, Taylor, John
The genome of hepatitis delta virus (HDV) is a 1,679-nucleotide (nt) single-stranded circular RNA that is predicted to fold into an unbranched rodlike structure. During replication, two complementary...
Song, Moon Jung, Brown, Helen J., Wu, Ting-Ting, Sun, Ren
Human herpesvirus 8 (HHV-8) (also known as Kaposi's sarcoma-associated herpesvirus) encodes a novel noncoding polyadenylated nuclear (PAN) RNA (also known as T1.1 or nut-1) during the early phase of...
Function of Rta Is Essential for Lytic Replication of Murine Gammaherpesvirus 68
Wu, Ting-Ting, Tong, Leming, Rickabaugh, Tammy, Speck, Samuel, Sun, Ren
Rta, encoded primarily by open reading frame 50, is well conserved among gammaherpesviruses. It has been shown that the Rta proteins of Epstein Barr virus (EBV), Kaposi's sarcoma-associated...
NF-κB Inhibits Gammaherpesvirus Lytic Replication
Brown, Helen J., Song, Moon Jung, Deng, Hongyu, Wu, Ting-Ting, Cheng, Genhong, Sun, Ren
Nasopharyngeal carcinoma, Kaposi's sarcoma, and B-cell lymphomas are human malignancies associated with gammaherpesvirus infections. Members of this virus family are characterized by their ability to...
Transcription Program of Murine Gammaherpesvirus 68
Martinez-Guzman, DeeAnn, Rickabaugh, Tammy, Wu, Ting-Ting, Brown, Helen, Cole, Steven, Song, Moon Jung, ...
Murine gammaherpesvirus 68 (MHV-68 [also referred to as γHV68]) is phylogenetically related to Kaposi's sarcoma-associated herpesvirus (KSHV [also referred to as HHV-8]) and Epstein-Barr virus...
Symensma , Tonia L., Martinez-Guzman, DeeAnn, Jia, Qingmei, Bortz, Eric, Wu, Ting-Ting, Rudra-Ganguly, Nandini, ...
The murine gammaherpesvirus 68 (MHV-68 or γHV-68) model provides many advantages for studying virus-host interactions involved in gammaherpesvirus replication, including the role of cellular...
Identification of Proteins Associated with Murine Gammaherpesvirus 68 Virions
Bortz, Eric, Whitelegge, Julian P., Jia, Qingmei, Zhou, Z. Hong, Stewart, James P., Wu, Ting-Ting, ...
Murine gammaherpesvirus 68 (MHV68 [also known as γHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying...
Murine Gammaherpesvirus 68 Open Reading Frame 31 Is Required for Viral Replication
Jia, Qingmei, Wu, Ting-Ting, Liao, Hsiang-I, Chernishof, Vasili, Sun, Ren
Murine gammaherpesvirus 68 (MHV-68) is genetically related to the human gammaherpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) and Epstein-Barr virus (EBV). It has been proposed as...
Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary Infection
Rickabaugh, Tammy M., Brown, Helen J., Martinez-Guzman, DeeAnn, Wu, Ting-Ting, Tong, Leming, Yu, Fuqu, ...
Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus-68 (MHV-68) establish latent infections and are associated with various types of malignancies. They are members of the gamma-2...
Ng, Alan K., Block, Timothy M., Aiamkitsumrit, Benjamas, Wang, Mengjun, Clementi, Emily, Wu, Ting-Ting, ...
Previous studies using a eukaryotic expression system indicated that the unusual stability of the latency-associated transcript (LAT) intron was due to its nonconsensus branchpoint sequence (T.-T Wu,...
Rickabaugh, Tammy M., Brown, Helen J., Wu, Ting-Ting, Song, Moon Jung, Hwang, Seungmin, Deng, Hongyu, ...
Murine gammaherpesvirus 68 (MHV-68), Kaposi's sarcoma-associated herpesvirus (HHV-8), and Epstein-Barr virus (EBV) are all members of the gammaherpesvirus family, characterized by their ability to...
Song, Moon Jung, Hwang, Seungmin, Wong, Wendy H., Wu, Ting-Ting, Lee, Sangmi, Liao, Hsiang-I, ...
γ-Herpesviruses, Epstein–Barr virus, and Kaposi's sarcoma-associated herpesvirus are important human pathogens, because they are involved in tumor development. Murine γ-herpesvirus-68 (MHV-68 or...
Jia, Qingmei, Chernishof, Vasili, Bortz, Eric, Mchardy, Ian, Wu, Ting-Ting, Liao, Hsiang-I, ...
Murine gammaherpesvirus 68 (MHV-68) has been developed as a model for the human gammaherpesviruses Epstein-Barr virus and human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus (HHV-8/KSHV),...
ORF18 Is a Transfactor That Is Essential for Late Gene Transcription of a Gammaherpesvirus
Arumugaswami, Vaithilingaraja, Wu, Ting-Ting, Martinez-Guzman, DeeAnn, Jia, Qingmei, Deng, Hongyu, Reyes, Nichole, ...
Lytic replication of the tumor-associated human gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus has important implications in pathogenesis and tumorigenesis....
Systematic Identification of Cellular Signals Reactivating Kaposi Sarcoma–Associated Herpesvirus
Yu, Fuqu, Harada, Josephine N, Brown, Helen J, Deng, Hongyu, Song, Moon Jung, Wu, Ting-Ting, ...
The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It is believed that cellular signals...
Wong, Elaine, Wu, Ting-Ting, Reyes, Nichole, Deng, Hongyu, Sun, Ren
Open reading frame 24 (ORF24) of murine gammaherpesvirus 68 (MHV-68) is conserved among beta- and gammaherpesviruses; however, its function in viral replication has not been defined. Using MHV-68 as...
Bortz, Eric, Wang, Lili, Jia, Qingmei, Wu, Ting-Ting, Whitelegge, Julian P., Deng, Hongyu, ...
The tegument, a semiordered matrix of proteins overlying the nucleocapsid and underlying the virion envelope, in viruses in the gamma subfamily of Herpesviridae is poorly understood. Murine...
A Novel Inhibitory Mechanism of Mitochondrion-Dependent Apoptosis by a Herpesviral Protein
Feng, Pinghui, Liang, Chengyu, Shin, Young C, E, Xiaofei, Zhang, Weijun, Gravel, Robyn, ...
Upon viral infection, cells undergo apoptosis as a defense against viral replication. Viruses, in turn, have evolved elaborate mechanisms to subvert apoptotic processes. Here, we report that a novel...