Su, Tin Tin, Sprenger, Frank, DiGregorio, Paul J., Campbell, Shelagh D., O’Farrell, Patrick H.
The cyclin proteolysis that accompanies the exit from mitosis in diverse systems appears to be essential for restoration of interphase. The early syncytial divisions of Drosophila embryos, however,...
Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.
Laurençon, Anne, Purdy, Amanda, Sekelsky, Jeff, Hawley, R Scott, Su, Tin Tin
ATM/ATR kinases act as signal transducers in eukaryotic DNA damage and replication checkpoints. Mutations in ATM/ATR homologs have pleiotropic effects that range from sterility to increased killing...
Su, Tin Tin, Sprenger, Frank, DiGregorio, Paul J., Campbell, Shelagh D., O’Farrell, Patrick H.
The cyclin proteolysis that accompanies the exit from mitosis in diverse systems appears to be essential for restoration of interphase. The early syncytial divisions of Drosophila embryos, however,...
Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.
Laurençon, Anne, Purdy, Amanda, Sekelsky, Jeff, Hawley, R Scott, Su, Tin Tin
ATM/ATR kinases act as signal transducers in eukaryotic DNA damage and replication checkpoints. Mutations in ATM/ATR homologs have pleiotropic effects that range from sterility to increased killing...
Wichmann, Anita, Jaklevic, Burnley, Su, Tin Tin
Ionizing radiation (IR) can induce apoptosis via p53, which is the most commonly mutated gene in human cancers. Loss of p53, however, can render cancer cells refractory to therapeutic effects of IR....
Drosophila ATR in Double-Strand Break Repair
LaRocque, Jeannine R., Jaklevic, Burnley, Su, Tin Tin, Sekelsky, Jeff
The ability of a cell to sense and respond to DNA damage is essential for genome stability. An important aspect of the response is arrest of the cell cycle, presumably to allow time for repair....
Chromosome Association of Minichromosome Maintenance Proteins in Drosophila Mitotic Cycles
Su, Tin Tin, O'Farrell, Patrick H.
Minichromosome maintenance (MCM) proteins are essential DNA replication factors conserved among eukaryotes. MCMs cycle between chromatin bound and dissociated states during each cell cycle. Their...
Chromosome Association of Minichromosome Maintenance Proteins in Drosophila Endoreplication Cycles
Su, Tin Tin, O'Farrell, Patrick H.
Minichromosome maintenance (MCM) proteins are essential eukaryotic DNA replication factors. The binding of MCMs to chromatin oscillates in conjunction with progress through the mitotic cell cycle....