Thomas Winckler

The Complex Repeats of Dictyostelium discoideum

Glöckner, Gernot, Szafranski, Karol, Winckler, Thomas, Dingermann, Theodor, Quail, Michael A., Cox, Edward, ...

In the course of determining the sequence of the Dictyostelium discoideum genome we have characterized in detail the quantity and nature of interspersed repetitive elements present in this species....

CbfA, the C-Module DNA-Binding Factor, Plays an Essential Role in the Initiation of Dictyostelium discoideum Development

Winckler, Thomas, Iranfar, Negin, Beck, Peter, Jennes, Ingo, Siol, Oliver, Baik, Unha, ...

We recently isolated from Dictyostelium discoideum cells a DNA-binding protein, CbfA, that interacts in vitro with a regulatory element in retrotransposon TRE5-A. We have generated a mutant strain...

The C-Module DNA-Binding Factor Mediates Expression of the Dictyostelium Aggregation-Specific Adenylyl Cyclase ACA

Siol, Oliver, Dingermann, Theodor, Winckler, Thomas

Aggregation of Dictyostelium discoideum amoebae into multicellular structures is organized by cyclic AMP (cAMP), which acts as a chemoattractant, as a second messenger, and as a morphogen....

The Complex Repeats of Dictyostelium discoideum

Glöckner, Gernot, Szafranski, Karol, Winckler, Thomas, Dingermann, Theodor, Quail, Michael A., Cox, Edward, ...

In the course of determining the sequence of the Dictyostelium discoideum genome we have characterized in detail the quantity and nature of interspersed repetitive elements present in this species....

CbfA, the C-Module DNA-Binding Factor, Plays an Essential Role in the Initiation of Dictyostelium discoideum Development

Winckler, Thomas, Iranfar, Negin, Beck, Peter, Jennes, Ingo, Siol, Oliver, Baik, Unha, ...

We recently isolated from Dictyostelium discoideum cells a DNA-binding protein, CbfA, that interacts in vitro with a regulatory element in retrotransposon TRE5-A. We have generated a mutant strain...

The C-Module DNA-Binding Factor Mediates Expression of the Dictyostelium Aggregation-Specific Adenylyl Cyclase ACA

Siol, Oliver, Dingermann, Theodor, Winckler, Thomas

Aggregation of Dictyostelium discoideum amoebae into multicellular structures is organized by cyclic AMP (cAMP), which acts as a chemoattractant, as a second messenger, and as a morphogen....

Role of RNA Polymerase III Transcription Factors in the Selection of Integration Sites by the Dictyostelium Non-Long Terminal Repeat Retrotransposon TRE5-A▿

Siol, Oliver, Boutliliss, Moustapha, Chung, Thanh, Glöckner, Gernot, Dingermann, Theodor, Winckler, Thomas

In the compact Dictyostelium discoideum genome, non-long terminal repeat (non-LTR) retrotransposons known as TREs avoid accidental integration-mediated gene disruption by targeting the vicinity of...

Protein Interactions Involved in tRNA Gene-Specific Integration of Dictyostelium discoideum Non-Long Terminal Repeat Retrotransposon TRE5-A▿

Chung, Thanh, Siol, Oliver, Dingermann, Theodor, Winckler, Thomas

Mobile genetic elements that reside in gene-dense genomes face the problem of avoiding devastating insertional mutagenesis of genes in their host cell genomes. To meet this challenge, some...