Rubins, Kathleen H, Hensley, Lisa E, Wahl-Jensen, Victoria, Daddario DiCaprio, Kathleen M, Young, Howard A, Reed, Douglas S, ...
Abstract Background Infection with Ebola virus (EBOV) causes a fulminant and often fatal hemorrhagic fever. In order to improve our understanding of EBOV pathogenesis and EBOV-host interactions, we...
Effective Post-Exposure Treatment of Ebola Infection (2007)
Heinz Feldmann, Steven M. Jones, Joan B. Geisbert, Ute Ströher, Allen Grolla, ...
Ebola viruses are highly lethal human pathogens that have received considerable attention in recent years due to an increasing re-emergence in Central Africa and a potential for use as a biological...
Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys (2007)
Wendelien B. Oswald, Thomas W. Geisbert, Kelly J. Davis, Joan B. Geisbert, Nancy J. Sullivan, Peter B. Jahrling, ...
Prophylaxis with high doses of neutralizing antibody typically offers protection against challenge with viruses producing acute infections. In this study, we have investigated the ability of the...
Nancy J. Sullivan, Thomas W. Geisbert, Joan B. Geisbert, Devon J. Shedlock, Ling Xu, Laurie Lamoreaux, ...
A simplified Ebola vaccine that consists of a modified GP protein (which is well-tolerated by human cells even at high concentrations) in a replication-defective adenoviral vector protects macaques.
Nancy J. Sullivan, Thomas W. Geisbert, Joan B. Geisbert, Devon J. Shedlock, Ling Xu, Laurie Lamoreaux, ...
BackgroundEbola virus causes a hemorrhagic fever syndrome that is associated with high mortality in humans. In the absence of effective therapies for Ebola virus infection, the development of a...
Masstag polymerase chain reaction for differential diagnosis of viral hemorrhagic fevers (2006)
Palacios, Gustavo, Briese, Thomas, Kapoor, Vishal, Jabado, Omar, Liu, Zhiqiang, Venter, Marietjie, ...
Viral hemorrhagic fevers are associated with high rates of illness and death. Although therapeutic options are limited, early differential diagnosis has implications for containment and may aid in...
Development of a New Vaccine for the Prevention of Lassa Fever (2005)
Thomas W. Geisbert, Steven Jones, Elizabeth A. Fritz, Amy C. Shurtleff, Joan B. Geisbert, Ryan Liebscher, ...
A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
Development of a New Vaccine for the Prevention of Lassa Fever (2005)
Thomas W. Geisbert, Steven Jones, Elizabeth A. Fritz, Amy C. Shurtleff, Joan B. Geisbert, Ryan Liebscher, ...
Background Recent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health...
Comparison of In-Vitro and In-Vivo Toxic Effects of Microcystin-LR in Fasted Rats (2003)
Miura, George A., Robinson, Nancy A., Geisbert, Thomas W., Bostian, Karen A., White, John D.
The toxic effects of microcystin-LR, a cyclic heptapeptide isolated from the blue-green alga Microcystis aeruginosa, were studied in the fasted rat model and in subcellular fractions from fasted,...
Toxicity and Kinetics of (3H)Microcystin-LR in Isolated Perfused Rat Livers (2003)
Pace, Judith G., Robinson, Nancy A., Miura, George A., Matson, Charles F., Geisbert, Thomas W.
Microcystin-LR (MCYST-LR) is a cyclic hepatotoxin isolated from the cyanobacterium Microcystis aeruginosa. Isolated rat livers were perfused for 60 min with either 0.3 or 0.5 microgram/ml (initial...
Pathogenesis of ebola hemorrhagic fever in primate models in vivo and in vitro / (2003)
Typescript (photocopy).
Filovirus Pathogenesis in Nonhuman Primates (1998)
Geisbert, Thomas W., Jahrling, Peter B., Larsen, Tom, Davis, Kelly J., Hensley, Lisa
Infections with Ebola and Marburg viruses cause severe and fatal hemorrhagic disease in humans and nonhuman primates. While progress to define the mechanisms of filoviral pathogenesis has been made...
Towards a Vaccine Against Ebola Virus (1998)
Geisbert, Thomas W., Jahrling, Peter B.
Ebola virus infection causes hemorrhagic fever with high mortality rates in humans and nonhuman primates. Currently, there are no vaccines or therapies approved for human use. Outbreaks of Ebola...
Ebola Virus: New Insights into Disease Aetiopathology and Possible Therapeutic Interventions (1998)
Geisbert, Thomas W., Hensley, Lisa E.
Ebola virus (EBOV) gained public notoriety in the last decade largely as a consequence of the highly publicised isolation of a new EBOV species in a suburb of Washington, DC, in 1989, together with...
Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques (1998)
Geisbert, Thomas W., Hensley, Lisa E., Larsen, Tom, Young, Howard A., Reed, Douglas S.
Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of...
Geisbert, Thomas W., Hensley, Lisa E., Jahrling, Peter B., Larsen, Tom, Geisbert, Joan B.
Infection with the Ebola virus induces overexpression of the procoagulant tissue factor in primate monocytes and macrophages, suggesting that inhibition of the tissue-factor pathway could ameliorate...
Bray, Mike, Geisbert, Thomas W.
Ebola hemorrhagic fever is a severe viral infection characterized by fever, shock and coagulation defects. Recent studies in macaques show that major features of illness are caused by effects of...
Jones, Steven M., Feldmann, Heinz, Stroher, Ute, Geisbert, Joan B., Fernando, Lisa, Grolla, Allen, ...
Vaccines and therapies are urgently needed to address public health needs stemming from emerging pathogens and biological threat agents such as the filoviruses Ebola virus (EBOV) and Marburg virus...
Daddario-DiCaprio, Kathleen M., Geisbert, Thomas W., Stroher, Ute, Geisbert, Joan B., Grolla, Allen, Fritz, Elizabeth A., ...
Effective countermeasures are urgently needed to prevent and treat infections caused by highly pathogenic and biological threat agents such as Marburg virus (MARV). We aimed to test the efficacy of a...
MassTag Polymerase Chain Reaction for Differential Diagnosis of Viral Hemorrhagic Fevers (1998)
Palacios, Gustavo, Briese, Thomas, Kapoor, Vishal, Jabado, Omar, Liu, Zhiqiang, Venter, Marietjie, ...
Viral hemorrhagic fevers are associated with high rates of illness and death. Although therapeutic options are limited, early differential diagnosis has implications for containment and may aid in...
Typescript.
Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
Yount, Boyd, Curtis, Kristopher M., Fritz, Elizabeth A., Hensley, Lisa E., Jahrling, Peter B., Prentice, Erik, ...
A previously undescribed coronavirus (CoV) is the etiologic agent responsible for severe acute respiratory syndrome (SARS). Using a panel of contiguous cDNAs that span the entire genome, we have...
Rubins, Kathleen H., Hensley, Lisa E., Jahrling, Peter B., Whitney, Adeline R., Geisbert, Thomas W., Huggins, John W., ...
Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the...
Development of a New Vaccine for the Prevention of Lassa Fever
Geisbert, Thomas W, Jones, Steven, Fritz, Elizabeth A, Shurtleff, Amy C, Geisbert, Joan B, Liebscher, Ryan, ...
A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
Sullivan, Nancy J, Geisbert, Thomas W, Geisbert, Joan B, Shedlock, Devon J, Xu, Ling, Lamoreaux, Laurie, ...
A simplified Ebola vaccine that consists of a modified GP protein (which is well-tolerated by human cells even at high concentrations) in a replication-defective adenoviral vector protects macaques.
Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
Yount, Boyd, Curtis, Kristopher M., Fritz, Elizabeth A., Hensley, Lisa E., Jahrling, Peter B., Prentice, Erik, ...
A previously undescribed coronavirus (CoV) is the etiologic agent responsible for severe acute respiratory syndrome (SARS). Using a panel of contiguous cDNAs that span the entire genome, we have...
Rubins, Kathleen H., Hensley, Lisa E., Jahrling, Peter B., Whitney, Adeline R., Geisbert, Thomas W., Huggins, John W., ...
Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the...
Development of a New Vaccine for the Prevention of Lassa Fever
Geisbert, Thomas W, Jones, Steven, Fritz, Elizabeth A, Shurtleff, Amy C, Geisbert, Joan B, Liebscher, Ryan, ...
A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
Sullivan, Nancy J, Geisbert, Thomas W, Geisbert, Joan B, Shedlock, Devon J, Xu, Ling, Lamoreaux, Laurie, ...
A simplified Ebola vaccine that consists of a modified GP protein (which is well-tolerated by human cells even at high concentrations) in a replication-defective adenoviral vector protects macaques.
Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys
Oswald, Wendelien B, Geisbert, Thomas W, Davis, Kelly J, Geisbert, Joan B, Sullivan, Nancy J, Jahrling, Peter B, ...
Prophylaxis with high doses of neutralizing antibody typically offers protection against challenge with viruses producing acute infections. In this study, we have investigated the ability of the...
Effective Post-Exposure Treatment of Ebola Infection
Feldmann, Heinz, Jones, Steven M, Daddario-DiCaprio, Kathleen M, Geisbert, Joan B, Ströher, Ute, Grolla, Allen, ...
Ebola viruses are highly lethal human pathogens that have received considerable attention in recent years due to an increasing re-emergence in Central Africa and a potential for use as a biological...
Cross-Protection against Marburg Virus Strains by Using a Live, Attenuated Recombinant Vaccine
Daddario-DiCaprio, Kathleen M., Geisbert, Thomas W., Geisbert, Joan B., Ströher, Ute, Hensley, Lisa E., Grolla, Allen, ...
Marburg virus (MARV) has been associated with sporadic episodes of hemorrhagic fever, including a recent highly publicized outbreak in Angola that produced severe disease and significant mortality in...
Geisbert, Thomas W., Hensley, Lisa E., Larsen, Tom, Young, Howard A., Reed, Douglas S., Geisbert, Joan B., ...
Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of...
Geisbert, Thomas W., Young, Howard A., Jahrling, Peter B., Davis, Kelly J., Larsen, Tom, Kagan, Elliott, ...
Ebola virus (EBOV) infection causes a severe and often fatal hemorrhagic disease in humans and nonhuman primates. Whether infection of endothelial cells is central to the pathogenesis of EBOV...
Neumann, Gabriele, Geisbert, Thomas W., Ebihara, Hideki, Geisbert, Joan B., Daddario-DiCaprio, Kathleen M., Feldmann, Heinz, ...
Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not...
Lipid Raft Microdomains: A Gateway for Compartmentalized Trafficking of Ebola and Marburg Viruses〉
Bavari, Sina, Bosio, Catharine M., Wiegand, Elizabeth, Ruthel, Gordon, Will, Amy B., Geisbert, Thomas W., ...
Spatiotemporal aspects of filovirus entry and release are poorly understood. Lipid rafts act as functional platforms for multiple cellular signaling and trafficking processes. Here, we report the...
Rubins, Kathleen H, Hensley, Lisa E, Wahl-Jensen, Victoria, Daddario DiCaprio, Kathleen M, Young, Howard A, Reed, Douglas S, ...
Primate blood cells were analysed for changes in global gene expression patterns at several time points following infection with Ebola virus, providing insights into potential mechanisms of viral...
Geisbert, Thomas W., Daddario-DiCaprio, Kathleen M., Williams, Kinola J. N., Geisbert, Joan B., Leung, Anders, Feldmann, Friederike, ...
Recombinant vesicular stomatitis virus (VSV) vectors expressing homologous filoviral glycoproteins can completely protect rhesus monkeys against Marburg virus when administered after exposure and can...
Geisbert, Thomas W., Daddario-DiCaprio, Kathleen M., Lewis, Mark G., Geisbert, Joan B., Grolla, Allen, Leung, Anders, ...
Ebola virus (EBOV) is a significant human pathogen that presents a public health concern as an emerging/re-emerging virus and as a potential biological weapon. Substantial progress has been made over...