Thomas H. Rhodes

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)

Benson, D. Woodrow, Wang, Dao W., Dyment, Macaira, Knilans, Timothy K., Fish, Frank A., Strieper, Margaret J., ...

Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to sinus node dysfunction and diagnosed by electrocardiographic demonstration of sinus bradycardia or sinus arrest. Although...

Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy

Rhodes, Thomas H., Lossin, Christoph, Vanoye, Carlos G., Wang, Dao W., George, Alfred L.

Mutations in SCN1A, the gene encoding the brain voltage-gated sodium channel α1 subunit (NaV1.1), are associated with at least two forms of epilepsy, generalized epilepsy with febrile seizures plus...

Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic–clonic seizures

Rhodes, Thomas H, Vanoye, Carlos G, Ohmori, Iori, Ogiwara, Ikuo, Yamakawa, Kazuhiro, George, Alfred L

Mutations in SCN1A, the gene encoding the brain voltage-gated sodium channel α1 subunit (NaV1.1), are associated with genetic forms of epilepsy, including generalized epilepsy with febrile seizures...

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)

Benson, D. Woodrow, Wang, Dao W., Dyment, Macaira, Knilans, Timothy K., Fish, Frank A., Strieper, Margaret J., ...

Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to sinus node dysfunction and diagnosed by electrocardiographic demonstration of sinus bradycardia or sinus arrest. Although...

Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy

Rhodes, Thomas H., Lossin, Christoph, Vanoye, Carlos G., Wang, Dao W., George, Alfred L.

Mutations in SCN1A, the gene encoding the brain voltage-gated sodium channel α1 subunit (NaV1.1), are associated with at least two forms of epilepsy, generalized epilepsy with febrile seizures plus...

Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic–clonic seizures

Rhodes, Thomas H, Vanoye, Carlos G, Ohmori, Iori, Ogiwara, Ikuo, Yamakawa, Kazuhiro, George, Alfred L

Mutations in SCN1A, the gene encoding the brain voltage-gated sodium channel α1 subunit (NaV1.1), are associated with genetic forms of epilepsy, including generalized epilepsy with febrile seizures...

Single-channel Properties of Human NaV1.1 and Mechanism of Channel Dysfunction in SCN1A-associated Epilepsy

Vanoye, Carlos G., Lossin, Christoph, Rhodes, Thomas H., George, Alfred L.

Mutations in genes encoding neuronal voltage-gated sodium channel subunits have been linked to inherited forms of epilepsy. The majority of mutations (>100) associated with generalized epilepsy with...

Effect of pH and salt bridges on structural assembly: Molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain

Kishan, K.V. Radha, Newcomer, Marcia E., Rhodes, Thomas H., Guilliot, Stephen D.

The SH3 domain of Eps8 was previously found to form an intertwined, domain-swapped dimer. We report here a monomeric structure of the EPS8 SH3 domain obtained from crystals grown at low pH, as well...