Apicoplast Lipoic Acid Protein Ligase B Is Not Essential for Plasmodium falciparum (2007)
Svenja Günther, Lynsey Wallace, Eva-Maria Patzewitz, Paul J. McMillan, Janet Storm, Carsten Wrenger, ...
Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation...
Structure, substrate recognition and reactivity of Leishmania majormevalonate kinase (2007)
Sgraja, Tanja, Smith, Terry K, Hunter, William N
Abstract Background Isoprenoid precursor synthesis via the mevalonate route in humans and pathogenic trypanosomatids is an important metabolic pathway. There is however, only limited information...
Structure, substrate recognition and reactivity of Leishmania majormevalonate kinase (2007)
Sgraja, Tanja, Smith, Terry K, Hunter, William N
Abstract Background Isoprenoid precursor synthesis via the mevalonate route in humans and pathogenic trypanosomatids is an important metabolic pathway. There is however, only limited information...
Wilner, Gabriel M., Smith, Terry K.
This article will focus on the legal environment within the State in regard to foreign investment and trade. In making this survey it is also necessary to note briefly the full context in which...
Smith, Terry K., Crossman, Arthur, Borissow, Charles N., Paterson, Michael J., Dix, Alex, Brimacombe, John S., ...
The substrate specificities of Trypanosoma brucei and human (HeLa) GlcNAc-PI de-N-acetylases were determined using 24 substrate analogues. The results show the following. (i) The de-N-acetylases show...
Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness
Smith, Terry K, Crossman, Arthur, Brimacombe, John S, Ferguson, Michael A J
It has been suggested that compounds affecting glycosylphosphatidylinositol (GPI) biosynthesis in bloodstream form Trypanosoma brucei should be trypanocidal. We describe cell-permeable analogues of a...
Membrane Topology and Transient Acylation of Toxoplasma gondii Glycosylphosphatidylinositols
Kimmel, Jürgen, Smith, Terry K., Azzouz, Nahid, Gerold, Peter, Seeber, Frank, Lingelbach, Klaus, ...
Using hypotonically permeabilized Toxoplasma gondii tachyzoites, we investigated the topology of the free glycosylphosphatidylinositols (GPIs) within the endoplasmic reticulum (ER) membrane. The...
Smith, Terry K., Crossman, Arthur, Borissow, Charles N., Paterson, Michael J., Dix, Alex, Brimacombe, John S., ...
The substrate specificities of Trypanosoma brucei and human (HeLa) GlcNAc-PI de-N-acetylases were determined using 24 substrate analogues. The results show the following. (i) The de-N-acetylases show...
Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness
Smith, Terry K, Crossman, Arthur, Brimacombe, John S, Ferguson, Michael A J
It has been suggested that compounds affecting glycosylphosphatidylinositol (GPI) biosynthesis in bloodstream form Trypanosoma brucei should be trypanocidal. We describe cell-permeable analogues of a...
Membrane Topology and Transient Acylation of Toxoplasma gondii Glycosylphosphatidylinositols
Kimmel, Jürgen, Smith, Terry K., Azzouz, Nahid, Gerold, Peter, Seeber, Frank, Lingelbach, Klaus, ...
Using hypotonically permeabilized Toxoplasma gondii tachyzoites, we investigated the topology of the free glycosylphosphatidylinositols (GPIs) within the endoplasmic reticulum (ER) membrane. The...
Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis
Buetow, Lori, Smith, Terry K., Dawson, Alice, Fyffe, Stewart, Hunter, William N.
The external layer of the Gram-negative bacterial outer membrane is primarily composed of a protective, selectively permeable LPS. The biosynthesis of LPS relies on UDP-3-O-acyl-glucosamine...
Apicoplast Lipoic Acid Protein Ligase B Is Not Essential for Plasmodium falciparum
Günther, Svenja, Wallace, Lynsey, Patzewitz, Eva-Maria, McMillan, Paul J, Storm, Janet, Wrenger, Carsten, ...
Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation...