Sylvaine Cases

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals

Meiner, Vardiella L., Cases, Sylvaine, Myers, Heather M., Sande, Eric R., Bellosta, Stefano, Schambelan, Morris, ...

The microsomal enzyme acyl-CoA:cholesterol acyltransferase (ACAT; EC 2.3.1.26) catalyzes the esterification of cellular cholesterol with fatty acids to form cholesterol esters. ACAT activity is found...

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

Cases, Sylvaine, Smith, Steven J., Zheng, Yao-Wu, Myers, Heather M., Lear, Steven R., Sande, Eric, ...

Triacylglycerols are quantitatively the most important storage form of energy for eukaryotic cells. Acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the terminal and only...

Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

Yen, Chi-Liang Eric, Stone, Scot J., Cases, Sylvaine, Zhou, Ping, Farese, Robert V.

Acyl-CoA:monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids. In the...

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Listenberger, Laura L., Han, Xianlin, Lewis, Sarah E., Cases, Sylvaine, Farese, Robert V., Ory, Daniel S., ...

Excess lipid accumulation in non-adipose tissues is associated with insulin resistance, pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the relative...

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals

Meiner, Vardiella L., Cases, Sylvaine, Myers, Heather M., Sande, Eric R., Bellosta, Stefano, Schambelan, Morris, ...

The microsomal enzyme acyl-CoA:cholesterol acyltransferase (ACAT; EC 2.3.1.26) catalyzes the esterification of cellular cholesterol with fatty acids to form cholesterol esters. ACAT activity is found...

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

Cases, Sylvaine, Smith, Steven J., Zheng, Yao-Wu, Myers, Heather M., Lear, Steven R., Sande, Eric, ...

Triacylglycerols are quantitatively the most important storage form of energy for eukaryotic cells. Acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the terminal and only...

Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

Yen, Chi-Liang Eric, Stone, Scot J., Cases, Sylvaine, Zhou, Ping, Farese, Robert V.

Acyl-CoA:monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids. In the...

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Listenberger, Laura L., Han, Xianlin, Lewis, Sarah E., Cases, Sylvaine, Farese, Robert V., Ory, Daniel S., ...

Excess lipid accumulation in non-adipose tissues is associated with insulin resistance, pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the relative...