Sylke Müller

Apicoplast Lipoic Acid Protein Ligase B Is Not Essential for Plasmodium falciparum (2007)

Svenja Günther, Lynsey Wallace, Eva-Maria Patzewitz, Paul J. McMillan, Janet Storm, Carsten Wrenger, ...

Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation...

Glutathione synthetase from Plasmodium falciparum.

Meierjohann, Svenja, Walter, Rolf D, Müller, Sylke

GSH is the major low-molecular-mass thiol in most organisms. The tripeptide maintains a reduced intracellular environment and protects cellular components from damaging oxidation. GSH is synthesized...

Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum.

Meierjohann, Svenja, Walter, Rolf D, Müller, Sylke

Malaria is one of the most devastating tropical diseases despite the availability of numerous drugs acting against the protozoan parasite Plasmodium in its human host. However, the development of...

3-Aminooxy-1-Aminopropane and Derivatives Have an Antiproliferative Effect on Cultured Plasmodium falciparum by Decreasing Intracellular Polyamine Concentrations

Das Gupta, Robin, Krause-Ihle, Tanja, Bergmann, Bärbel, Müller, Ingrid B., Khomutov, Alex R., Müller, Sylke, ...

The intraerythrocytic development of Plasmodium falciparum correlates with increasing levels of the polyamines putrescine, spermidine, and spermine in the infected red blood cells; and compartmental...

Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis

Wickramasinghe, Sasala R., Inglis, Kirstine A., Urch, Jonathan E., Müller, Sylke, Van Aalten, Daan M. F., Fairlamb, Alan H.

Type II fatty acid biosynthesis represents an attractive target for the discovery of new antimalarial drugs. Previous studies have identified malarial ENR (enoyl acyl-carrier-protein reductase, or...

Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum

Boucher, Ian W, McMillan, Paul J, Gabrielsen, Mads, Akerman, Susan E, Brannigan, James A, Schnick, Claudia, ...

Plasmodium falciparum possesses a single mitochondrion with a functional electron transport chain. During respiration, reactive oxygen species are generated that need to be removed to protect the...

3-Aminooxy-1-Aminopropane and Derivatives Have an Antiproliferative Effect on Cultured Plasmodium falciparum by Decreasing Intracellular Polyamine Concentrations

Das Gupta, Robin, Krause-Ihle, Tanja, Bergmann, Bärbel, Müller, Ingrid B., Khomutov, Alex R., Müller, Sylke, ...

The intraerythrocytic development of Plasmodium falciparum correlates with increasing levels of the polyamines putrescine, spermidine, and spermine in the infected red blood cells; and compartmental...

Glutathione synthetase from Plasmodium falciparum.

Meierjohann, Svenja, Walter, Rolf D, Müller, Sylke

GSH is the major low-molecular-mass thiol in most organisms. The tripeptide maintains a reduced intracellular environment and protects cellular components from damaging oxidation. GSH is synthesized...

Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum.

Meierjohann, Svenja, Walter, Rolf D, Müller, Sylke

Malaria is one of the most devastating tropical diseases despite the availability of numerous drugs acting against the protozoan parasite Plasmodium in its human host. However, the development of...

Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis

Wickramasinghe, Sasala R., Inglis, Kirstine A., Urch, Jonathan E., Müller, Sylke, Van Aalten, Daan M. F., Fairlamb, Alan H.

Type II fatty acid biosynthesis represents an attractive target for the discovery of new antimalarial drugs. Previous studies have identified malarial ENR (enoyl acyl-carrier-protein reductase, or...

Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum

Boucher, Ian W, McMillan, Paul J, Gabrielsen, Mads, Akerman, Susan E, Brannigan, James A, Schnick, Claudia, ...

Plasmodium falciparum possesses a single mitochondrion with a functional electron transport chain. During respiration, reactive oxygen species are generated that need to be removed to protect the...

Apicoplast Lipoic Acid Protein Ligase B Is Not Essential for Plasmodium falciparum

Günther, Svenja, Wallace, Lynsey, Patzewitz, Eva-Maria, McMillan, Paul J, Storm, Janet, Wrenger, Carsten, ...

Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation...