Sven J. Saupe

The genome sequence of Podospora anserina, a classic model fungus (2008)

Paoletti, Mathieu, Saupe, Sven J

Abstract The completed genome sequence of the coprophilous fungus Podospora anserina increases the sampling of fungal genomes. In line with its habitat of herbivore dung, this ascomycete has an...

Evidence for balancing selection operating at the het-c heterokaryon incompatibility locus in a group of filamentous fungi

Wu, Jennifer, Saupe, Sven J., Glass, N. Louise

In filamentous fungi, het loci (for heterokaryon incompatibility) are believed to regulate self/nonself-recognition during vegetative growth. As filamentous fungi grow, hyphal fusion occurs within an...

Molecular Genetics of Heterokaryon Incompatibility in Filamentous Ascomycetes

Saupe, Sven J.

Filamentous fungi spontaneously undergo vegetative cell fusion events within but also between individuals. These cell fusions (anastomoses) lead to cytoplasmic mixing and to the formation of...

Amyloid aggregates of the HET-s prion protein are infectious

Maddelein, Marie-Lise, Dos Reis, Suzana, Duvezin-Caubet, Stéphane, Coulary-Salin, Bénédicte, Saupe, Sven J.

The [Het-s] infectious element of the filamentous fungus Podospora anserina is a prion. We have recently reported that recombinant HET-s protein aggregates in vitro into amyloid fibers. In vivo, the...

Rapamycin Mimics the Incompatibility Reaction in the Fungus Podospora anserina

Dementhon, Karine, Paoletti, Mathieu, Pinan-Lucarré, Bérangère, Loubradou-Bourges, Nathalie, Sabourin, Martine, Saupe, Sven J., ...

In filamentous fungi, a programmed cell death (PCD) reaction occurs when cells of unlike genotype fuse. This reaction is caused by genetic differences at specific loci termed het loci (for...

Domain organization and structure–function relationship of the HET-s prion protein of Podospora anserina

Balguerie, Axelle, Dos Reis, Suzana, Ritter, Christiane, Chaignepain, Stéphane, Coulary-Salin, Bénédicte, Forge, Vincent, ...

The [Het-s] infectious element of the fungus Podospora anserina is a prion protein involved in a genetically controlled cell death reaction termed heterokaryon incompatibility. Previous analyses...

Sexual transmission of the [Het-s] prion leads to meiotic drive in Podospora anserina

Dalstra, Henk J. P., Swart, Klaas, Debets, Alfons J. M., Saupe, Sven J., Hoekstra, Rolf F.

In the filamentous fungus Podospora anserina, two phenomena are associated with polymorphism at the het-s locus, vegetative incompatibility and ascospore abortion. Two het-s alleles occur naturally,...

DNA-Binding Specificity of the IDI-4 Basic Leucine Zipper Factor of Podospora anserina Defined by Systematic Evolution of Ligands by Exponential Enrichment (SELEX)

Dementhon, Karine, Saupe, Sven J.

Heterokaryon incompatibility is a cell destruction process that occurs when fungal cells of unlike genotype fuse. In Podospora anserina, autophagy is engaged during cell death by incompatibility and...

Evidence for balancing selection operating at the het-c heterokaryon incompatibility locus in a group of filamentous fungi

Wu, Jennifer, Saupe, Sven J., Glass, N. Louise

In filamentous fungi, het loci (for heterokaryon incompatibility) are believed to regulate self/nonself-recognition during vegetative growth. As filamentous fungi grow, hyphal fusion occurs within an...

Molecular Genetics of Heterokaryon Incompatibility in Filamentous Ascomycetes

Saupe, Sven J.

Filamentous fungi spontaneously undergo vegetative cell fusion events within but also between individuals. These cell fusions (anastomoses) lead to cytoplasmic mixing and to the formation of...

Amyloid aggregates of the HET-s prion protein are infectious

Maddelein, Marie-Lise, Dos Reis, Suzana, Duvezin-Caubet, Stéphane, Coulary-Salin, Bénédicte, Saupe, Sven J.

The [Het-s] infectious element of the filamentous fungus Podospora anserina is a prion. We have recently reported that recombinant HET-s protein aggregates in vitro into amyloid fibers. In vivo, the...

Rapamycin Mimics the Incompatibility Reaction in the Fungus Podospora anserina

Dementhon, Karine, Paoletti, Mathieu, Pinan-Lucarré, Bérangère, Loubradou-Bourges, Nathalie, Sabourin, Martine, Saupe, Sven J., ...

In filamentous fungi, a programmed cell death (PCD) reaction occurs when cells of unlike genotype fuse. This reaction is caused by genetic differences at specific loci termed het loci (for...

Domain organization and structure–function relationship of the HET-s prion protein of Podospora anserina

Balguerie, Axelle, Dos Reis, Suzana, Ritter, Christiane, Chaignepain, Stéphane, Coulary-Salin, Bénédicte, Forge, Vincent, ...

The [Het-s] infectious element of the fungus Podospora anserina is a prion protein involved in a genetically controlled cell death reaction termed heterokaryon incompatibility. Previous analyses...

Sexual transmission of the [Het-s] prion leads to meiotic drive in Podospora anserina

Dalstra, Henk J. P., Swart, Klaas, Debets, Alfons J. M., Saupe, Sven J., Hoekstra, Rolf F.

In the filamentous fungus Podospora anserina, two phenomena are associated with polymorphism at the het-s locus, vegetative incompatibility and ascospore abortion. Two het-s alleles occur naturally,...

DNA-Binding Specificity of the IDI-4 Basic Leucine Zipper Factor of Podospora anserina Defined by Systematic Evolution of Ligands by Exponential Enrichment (SELEX)

Dementhon, Karine, Saupe, Sven J.

Heterokaryon incompatibility is a cell destruction process that occurs when fungal cells of unlike genotype fuse. In Podospora anserina, autophagy is engaged during cell death by incompatibility and...

Genesis of a Fungal Non-Self Recognition Repertoire

Paoletti, Mathieu, Saupe, Sven J., Clavé, Corinne

Conspecific allorecognition, the ability for an organism to discriminate its own cells from those of another individual of the same species, has been developed by many organisms. Allorecognition...

Role of Hsp104 in the Propagation and Inheritance of the [Het-s] Prion

Malato, Laurent, Dos Reis, Suzana, Benkemoun, Laura, Sabaté, Raimon, Saupe, Sven J.

The chaperones of the ClpB/HSP100 family play a central role in thermotolerance in bacteria, plants, and fungi by ensuring solubilization of heat-induced protein aggregates. In addition in yeast,...

The genome sequence of Podospora anserina, a classic model fungus

Paoletti, Mathieu, Saupe, Sven J

The genome sequence of the coprophilous fungus Podospora anserina shows both typical ascomycete features and how this species is adapted to its specialized environment.