Metabolic changes in schizophrenia and human brain evolution (2008)
Khaitovich, Philipp, Lockstone, Helen E, Wayland, Matthew T, Tsang, Tsz M, Jayatilaka, Samantha D, Guo, Arfu J, ...
Abstract Background Despite decades of research, the molecular changes responsible for the evolution of human cognitive abilities remain unknown. Comparative evolutionary studies provide detailed...
Krause, Johannes, Unger, Tina, Noçon, Aline, Malaspinas, Anna-Sapfo, Kolokotronis, Sergios-Orestis, Stiller, Mathias, ...
Abstract Background Despite being one of the most studied families within the Carnivora, the phylogenetic relationships among the members of the bear family (Ursidae) have long remained unclear....
Albert, Frank W., Shchepina, Olesya, Winter, Christine, Römpler, Holger, Teupser, Daniel, Palme, Rupert, ...
Meyer, Matthias, Briggs, Adrian W., Maricic, Tomislav, Höber, Barbara, Höffner, Barbara, Krause, Johannes, ...
Groszer, Matthias, Keays, David A., Deacon, Robert M.J., De Bono, Joseph P., Prasad-Mulcare, Shweta, Gaub, Simone, ...
Prüfer, Kay, Muetzel, Bjoern, Do, Hong-Hai, Weiss, Gunter, Khaitovich, Philipp, Rahm, Erhard, ...
Abstract Background Genome-wide expression, sequence and association studies typically yield large sets of gene candidates, which must then be further analysed and interpreted. Information about...
Sudden replacement of cave bear mitochondrial DNA in the late Pleistocene (2007)
Hofreiter, Michael, Münzel, Susanne, Conard, Nicholas J., Pollack, Joshua, Slatkin, Montgomery, Weiss, Gunter, ...
Patterns of damage in genomic DNA sequences from a Neandertal (2007)
Briggs, Adrian W., Stenzel, Udo, Johnson, Philip L. F., Green, Richard E., Kelso, Janet, Prüfer, Kay, ...
Neanderthals in central Asia and Siberia (2007)
Krause, Johannes, Orlando, Ludivic, Serre, David, Bence, Viola, Prüfer, Kay, Richards, Michael P., ...
The Joint Allele-Frequency Spectrum in Closely Related Species (2007)
Chen, Hua, Green, Richard E., Pääbo, Svante, Slatkin, Montgomery
The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals (2007)
Krause, Johannes, Lalueza-Fox, Carles, Ludovic, Orlando, Enard, Wolfgang, Green, Richard E., Burbano, Hernán A., ...
The Complex Evolutionary History of Gorillas: Insights from Genomic Data (2007)
Thalmann, Olaf, Fischer, Anne, Lankester, F. H., Pääbo, Svante, Vigilant, Linda
The Complex Evolutionary History of Gorillas (2007)
Vigilant, Linda, Thalmann, Olaf, Fischer, Anne, Pääbo, Svante
Molecular breeding of polymerases for amplification of ancient DNA (2007)
D'Abbadie, Marc, Hofreiter, Michael, Vaisman, Alexandra, Loakes, David, Gasparutto, Didier, Cadet, Jean, ...
Comparison of Protein and mRNA Expression Evolution in Humans and Chimpanzees (2007)
Fu, Ning, Drinnenberg, Ines, Kelso, Janet, Wu, Jia-Rui, Pääbo, Svante, Zeng, Rong, ...
Functionality of Intergenic Transcription: An Evolutionary Comparison (2006)
Philipp Khaitovich, Janet Kelso, Henriette Franz, Johann Visagie, Thomas Giger, Sabrina Joerchel, ...
Although a large proportion of human transcription occurs outside the boundaries of known genes, the functional significance of this transcription remains unknown. We have compared the expression...
Functionality of Intergenic Transcription: An Evolutionary Comparison (2006)
Philipp Khaitovich, Janet Kelso, Henriette Franz, Johann Visagie, Thomas Giger, Sabrina Joerchel, ...
Although a large proportion of human transcription occurs outside the boundaries of known genes, the functional significance of this transcription remains unknown. We have compared the expression...
Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae (2006)
Krause, Johannes, Dear, Paul H., Pollack, Joshua L., Slatkin, Montgomery, Spriggs, Helen, Barnes, Ian, ...
Evolution of primate gene expression (2006)
Khaitovich, Philipp, Enard, Wolfgang, Lachmann, Michael, Pääbo, Svante
Functionality of Intergenic Transcription : an Evolutionary Comparison (2006)
Khaitovich, Philipp, Kelso, Janet, Franz, Henriette, Visagie, Johann, Giger, Thomas, Joerchel, Sabrina, ...
Accelerated Evolution of Conserved Noncoding Sequences in Humans (2006)
Prabhakar, Shyam, Noonan, James, Pääbo, Svante, Rubin, Edward M.
The Complex Evolutionary History of Gorillas : Insights from Genomic Data (2006)
Thalmann, Olaf, Fischer, Anne, Lankester, F., Pääbo, Svante, Vigilant, Linda
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells (2006)
Fish, Jennifer L., Kosodo, Yoichi, Enard, Wolfgang, Pääbo, Svante, Huttner, Wieland B.
Demographic History and Genetic Differentiation in Apes (2006)
Fischer, Anne, Pollack, Joshua, Thalmann, Olaf, Nickel, Birgit, Pääbo, Svante
Positive selection on gene expression in the human brain (2006)
Khaitovich, Philipp, Tang, Kun, Franz, Henriette, Kelso, Janet, Hellmann, Ines, Enard, Wolfgang, ...
Gene expression becomes heterogeneous with age (2006)
Somel, Mehmet, Khaitovich, Philipp, Bahn, Sabine, Pääbo, Svante, Lachmann, Michael
Analysis of one million base pairs of Neanderthal DNA (2006)
Green, Richard E., Krause, Johannes, Ptak, Susan E., Briggs, Adrian W., Ronan, Michael T., Simons, Jan F., ...
Sequencing and analysis of Neanderthal genomic DNA (2006)
Noonan, J.P., Coop, G., Kudaravalli, S., Smith, D., Krause, Johannes, Alessi, J., ...
No evidence of Neanderthal mtDNA contribution to early modern humans (2006)
Serre, David, Langaney, A., Chech, M., Teschler-Nicola, M., Paunovic, M., Mennecier, P., ...
Structure of the forkhead domain of FOXP2 bound to DNA (2006)
Stroud, J. C., Wu, Y. Q., Bates, D. L., Han, A. D., Nowick, Katja, Pääbo, Svante, ...
Systematic analysis of gene expression in human brains before and after death (2005)
Franz, Henriette, Ullmann, Claudia, Becker, Albert, Ryan, Margaret, Bahn, Sabine, Arendt, Thomas, ...
Abstract Background Numerous studies have employed microarray techniques to study changes in gene expression in connection with human disease, aging and evolution. The vast majority of human samples...
Aging and Gene Expression in the Primate Brain (2005)
Hunter B. Fraser, Philipp Khaitovich, Joshua B. Plotkin, Svante Pääbo, Michael B. Eisen
Transcriptional profiles in human and chimpanzee reveal a diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species.
Aging and Gene Expression in the Primate Brain (2005)
Hunter B. Fraser, Philipp Khaitovich, Joshua B. Plotkin, Svante Pääbo, Michael B. Eisen
It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes...
Functional analysis of human and chimpanzee promoters (2005)
Heissig, Florian, Krause, Johannes, Bryk, Jaroslaw, Khaitovich, Philipp, Enard, Wolfgang, Pääbo, Svante
Abstract Background It has long been argued that changes in gene expression may provide an additional and crucial perspective on the evolutionary differences between humans and chimpanzees. To...
Chris T. Yohn, Zhaoshi Jiang, Sean D. McGrath, Karen E. Hayden, Philipp Khaitovich, Matthew E. Johnson, ...
Comparison of human and other primate genomes provides evidence for a retroviral infection that bombarded the genomes of chimpanzees and gorillas 3-4 million years ago.
Chris T. Yohn, Zhaoshi Jiang, Sean D. McGrath, Karen E. Hayden, Philipp Khaitovich, Matthew E. Johnson, ...
Retroviral infections of the germline have the potential to episodically alter gene function and genome structure during the course of evolution. Horizontal transmissions between species have been...
Fine-scale recombination patterns differ between chimpanzees and humans (2005)
Ptak, Susan E., Hinds, David A., Koehler, Kathrin, Nickel, Birgit, Patil, Nila, Ballinger, Dennis G., ...
Inversions, deletions and insertions are important mediators of disease and disease susceptibility. We systematically compared the human genome reference sequence with a second genome (represented by...
Yohn, Chris T., Jiang, Zhaoshi, McGrath, Sean D., Hayden, Karen E., Khaitovich, Philipp, Johnson, Matthew E., ...
Genomic sequencing of Pleistocene Cave Bears (2005)
Noonan, James P., Hofreiter, Michael, Smith, Doug, Priest, James R., Rohland, Nadin, Rabeder, Gernot, ...
Despite the greater information content of genomic DNA, ancient DNA studies have largely been limited to the amplification of mitochondrial sequences. Here we describe metagenomic libraries...
Functional analysis of human and chimpanzee promoters (2005)
Heissig, Florian, Krause, Johannes, Bryk, Jaroslaw, Khaitovich, Philipp, Enard, Wolfgang, Pääbo, Svante
Aging and Gene Expression in the Primate Brain (2005)
Fraser, Hunter B., Khaitovich, Philipp, Plotkin, Joshua B., Pääbo, Svante, Eisen, Michael B.
It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes...
Systematic analysis of gene expression in human brains before and after death (2005)
Franz, H., Ullmann, C., Becker, A., Ryan, M., Bahn, S., Arendt, T., ...
BACKGROUND: Numerous studies have employed microarray techniques to study changes in gene expression in connection with human disease, aging and evolution. The vast majority of human samples...
The rise and fall of the chemoattractant receptor GPR33 (2005)
Römpler, H., Schulz, A., Pitra, C., Coop, G., Przeworski, Molly, Pääbo, Svante, ...
Chemokine and chemoattractant receptors are members of the large superfamily of G protein- coupled receptors ( GPCR), which control leukocyte chemotaxis. In addition to their physiological role,...
Initial sequence of the chimpanzee genome and comparison with the human genome (2005)
Mikkelsen, Tarjei S., Hillier, LaDeana W., Eichler, Evan E., Zody, Michael C., Jaffe, David B., Yang, Shiaw-Pyng, ...
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences...
The population history of extant and extinct hyenas (2005)
Rohland, Nadin, Pollack, J. L., Nagel, D., Beauval, C., Airvaux, J., Pääbo, Svante, ...
Why do human diversity levels vary at a megabase scale? (2005)
Hellmann, Ines, Prüfer, Kai, Ji, H. K., Zody, M. C., Pääbo, Svante, Ptak, Susan E.
A late Neandertal femur from Les Rochers-de-Villeneuve, France (2005)
Beauval, C., Maureille, B., Lacrampe-Cuyaubere, F., Serre, D., Peressinotto, D., Bordes, J. G., ...
A genome-wide comparison of recent chimpanzee and human segmental duplications (2005)
Cheng, Z., Ventura, M., She, X. W., Khaitovich, Philipp, Graves, T., Osoegawa, K., ...
We present a global comparison of differences in content of segmental duplication between human and chimpanzee, and determine that 33% of human duplications (>94% sequence identity) are not...
Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees (2005)
Khaitovich, Philipp, Hellmann, Ines, Enard, Wolfgang, Nowick, Katja, Leinweber, M., Franz, H., ...
Absence of the TAP2 Human Recombination Hotspot in Chimpanzees (2004)
Susan E. Ptak, Amy D. Roeder, Matthew Stephens, Yoav Gilad, Svante Pääbo, Molly Przeworski
The human TAP2 recombination hotspot is absent from the homologous region in western chimpanzees, with important implications for association studies, the HapMap project and understanding fine-scale...
Absence of the TAP2 Human Recombination Hotspot in Chimpanzees (2004)
Susan E. Ptak, Amy D. Roeder, Matthew Stephens, Yoav Gilad, Svante Pääbo, Molly Przeworski
Recent experiments using sperm typing have demonstrated that, in several regions of the human genome, recombination does not occur uniformly but instead is concentrated in “hotspots” of 1–2 kb....
A Neutral Model of Transcriptome Evolution (2004)
Philipp Khaitovich, Gunter Weiss, Michael Lachmann, Ines Hellmann, Wolfgang Enard, Bjoern Muetzel, ...
Analysis of differences in gene expression between primate species suggests that the majority of them are selectively neutral and likely to have little or no functional consequences.
A Neutral Model of Transcriptome Evolution (2004)
Philipp Khaitovich, Gunter Weiss, Michael Lachmann, Ines Hellmann, Wolfgang Enard, Bjoern Muetzel, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
No Evidence of Neandertal mtDNA Contribution to Early Modern Humans (2004)
David Serre, André Langaney, Mario Chech, Maria Teschler-Nicola, Maja Paunovic, Philippe Mennecier, ...
Analysis of mitochondrial DNA from four Neandertal fossils and five "modern human" contemporaries excludes any large genetic contribution of Neandertals to the gene pool of modern humans.
No Evidence of Neandertal mtDNA Contribution to Early Modern Humans (2004)
David Serre, André Langaney, Mario Chech, Maria Teschler-Nicola, Maja Paunovic, Philippe Mennecier, ...
The retrieval of mitochondrial DNA (mtDNA) sequences from four Neandertal fossils from Germany, Russia, and Croatia has demonstrated that these individuals carried closely related mtDNAs that are not...