Susan K. Service

Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population

McInnes, L. Alison, Service, Susan K., Reus, Victor I., Barnes, Glenn, Charlat, Olga, Jawahar, Satya, ...

We have searched for genes predisposing to bipolar disorder (BP) by studying individuals with the most extreme form of the affected phenotype, BP-I, ascertained from the genetically isolated...

Hereditary Vascular Retinopathy, Cerebroretinal Vasculopathy, and Hereditary Endotheliopathy with Retinopathy, Nephropathy, and Stroke Map to a Single Locus on Chromosome 3p21.1-p21.3

Ophoff, Roel A., DeYoung, Joseph, Service, Susan K., Joosse, Marijke, Caffo, Nathan A., Sandkuijl, Lodewijk A., ...

We performed a genomewide search for linkage in an extended Dutch family with hereditary vascular retinopathy associated with migraine and Raynaud phenomenon. Patients with vascular retinopathy are...

Linkage Analysis of a Complex Pedigree with Severe Bipolar Disorder, Using a Markov Chain Monte Carlo Method

Garner, Chad, McInnes, L. Alison, Service, Susan K., Spesny, Mitzi, Fournier, Eduardo, Leon, Pedro, ...

Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package SimWalk2,...

Familial Aggregation of Absolute Pitch

Baharloo, Siamak, Service, Susan K., Risch, Neil, Gitschier, Jane, Freimer, Nelson B.

Absolute pitch (AP) is a behavioral trait that is defined as the ability to identify the pitch of tones in the absence of a reference pitch. AP is an ideal phenotype for investigation of gene and...

Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population

McInnes, L. Alison, Service, Susan K., Reus, Victor I., Barnes, Glenn, Charlat, Olga, Jawahar, Satya, ...

We have searched for genes predisposing to bipolar disorder (BP) by studying individuals with the most extreme form of the affected phenotype, BP-I, ascertained from the genetically isolated...

Genomewide Linkage Disequilibrium Mapping of Severe Bipolar Disorder in a Population Isolate

Ophoff, Roel A., Escamilla, Michael A., Service, Susan K., Spesny, Mitzi, Meshi, Dar B., Poon, Wingman, ...

Genomewide association studies may offer the best promise for genetic mapping of complex traits. Such studies in outbred populations require very densely spaced single-nucleotide polymorphisms. In...

Cost-Effective Designs for Linkage Disequilibrium Mapping of Complex Traits

Service, Susan K., Sandkuijl, Lodewijk A., Freimer, Nelson B.

The current development of densely spaced collections of single nucleotide polymorphisms (SNPs) will lead to genomewide association studies for a wide range of diseases in many different populations....

Hereditary Vascular Retinopathy, Cerebroretinal Vasculopathy, and Hereditary Endotheliopathy with Retinopathy, Nephropathy, and Stroke Map to a Single Locus on Chromosome 3p21.1-p21.3

Ophoff, Roel A., DeYoung, Joseph, Service, Susan K., Joosse, Marijke, Caffo, Nathan A., Sandkuijl, Lodewijk A., ...

We performed a genomewide search for linkage in an extended Dutch family with hereditary vascular retinopathy associated with migraine and Raynaud phenomenon. Patients with vascular retinopathy are...

Linkage Analysis of a Complex Pedigree with Severe Bipolar Disorder, Using a Markov Chain Monte Carlo Method

Garner, Chad, McInnes, L. Alison, Service, Susan K., Spesny, Mitzi, Fournier, Eduardo, Leon, Pedro, ...

Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package SimWalk2,...

Familial Aggregation of Absolute Pitch

Baharloo, Siamak, Service, Susan K., Risch, Neil, Gitschier, Jane, Freimer, Nelson B.

Absolute pitch (AP) is a behavioral trait that is defined as the ability to identify the pitch of tones in the absence of a reference pitch. AP is an ideal phenotype for investigation of gene and...

A quantitative trait locus for variation in dopamine metabolism mapped in a primate model using reference sequences from related species

Freimer, Nelson B., Service, Susan K., Ophoff, Roel A., Jasinska, Anna J., McKee, Kevin, Villeneuve, Amelie, ...

Non-human primates (NHP) provide crucial research models. Their strong similarities to humans make them particularly valuable for understanding complex behavioral traits and brain structure and...